Genitourinary Cancer Care in Orange County
City of Hope offers the most innovative treatments led internationally recognized physician scientists. When treating - genitourinary cancer -, our dedicated team of experts takes a uniquely integrated, patient-centered approach, may it be prostate, kidney, bladder, testicular or penile cancer, to ensure optimal outcomes with minimal impact on quality of life.
Why Choose City of Hope Orange County for Prostate Cancer Care?
City of Hope is a National Cancer Institute-designated comprehensive cancer center that offers patients in Orange County exceptional prostate cancer expertise and leading-edge prostate cancer treatments.
- Targeted, transperineal prostate biopsy
- Next-generation genetic screening and prevention programs
- Precision medicine and targeted therapies
- Minimally invasive surgical techniques
- Clinical trials of groundbreaking new treatments
- Renowned physicians and researchers
- Our interdisciplinary team works with patients to develop an individualized and highly coordinated treatment plan based on their unique needs.
- City of Hope Orange County offers the gold standard of prostate cancer testing known as targeted, transparent perineal prostate biopsies. By combining this biopsy with sophisticated MRI technology, City of Hope Orange County can increase the accuracy of detecting abnormalities in the prostate, reducing the likelihood of false negatives and the need for subsequent biopsies.
We Specialize in State-of-the-Art Treatments for Genitourinary Cancer
Our advanced cancer treatments include:
- City of Hope is a leader in minimally invasive, robotically assisted prostatectomies, which use a surgical robot and smaller incisions to remove the diseased prostate and surrounding tissue.
- Image-guided external radiation systems, including TomoTherapy and TrueBeam, combining detailed imaging and radiation delivery technologies, allowing our care team to “sculpt” radiation beams to the tumor site while avoiding nearby healthy tissue.
- MRI-guided focused ultrasound, a non-radiation technology, using magnetic resonance imaging (MRI) to detail images of the prostate area, followed by highly focused ultrasound to heat up and destroy cancerous tissue.
- Brachytherapy, which places radioactive material next to or within the tumor site. Depending on the cancer stage, your needs and treatment goals, radioactive material may be low-dose and permanently placed (low dose rate/LDR brachytherapy) or high-dose and placed for only a few minutes (high dose rate/HDR brachytherapy).
- Hormone therapy, blocking production or activity of hormones — particularly testosterone and dihydrotestosterone (DHT), which fuel most prostate cancer growth.
- Chemotherapy, targeting all rapidly dividing cells, including prostate cancer cells.
- Targeted therapy, which selectively attacks prostate cancer cells based on specific characteristics — such as a gene mutation.
- Immunotherapy, which stimulates your immune system to attack cancer cells.
- Active surveillance, effective for early-stage, slow-growing prostate cancers. This approach includes regular monitoring of prostate-specific antigen (PSA) levels and digital rectal examinations of the prostate. If abnormalities or symptoms arise, you and your physician can discuss treating the cancer.
- Access to a wide variety of clinical trials, including new chemotherapy and targeted therapies, hormone therapies with fewer side effects, novel surgical techniques, innovative radiation approaches and new prevention strategies.
Clinical trial participation is a critical aspect of care for many patients living with cancer. Our patients can access more than 1,000 innovative Phase 1–3 clinical trials at City of Hope each year — more cancer-focused clinical trials than anywhere in the area — to provide promising new treatments long before they become the standard of care.

A trailblazing integrative medicine program combining the best of Western medicine and evidence-based complementary therapies, such as acupuncture, massage and meditation.
City of Hope is a national leader in evidence-based supportive care. The Sheri & Les Biller Patient and Family Resource Center at the Lennar Foundation Cancer Center will facilitate easy access to a wide range of programs, including care navigation, survivorship programs, psychological and spiritual counseling, pain management and more.
Marybelle's is a full-service salon extending a specialty shopping experience with oncology-trained cosmetologists.
The on-site pharmacy fills and dispenses prescriptions and offers over-the-counter medications, alleviating the burden of going elsewhere.
A Grateful Patient Story
Orange County Prostate Cancer Doctors
City of Hope cancer specialists deliver outstanding prostate cancer outcomes that are difficult to achieve elsewhere.
Prostate & Genitourinary Cancer Leadership


Jeffrey S. Yoshida, M.D. recognizes that each of his patients carries a unique personality and background — as does their cancer. For that reason, he believes that medical care should be customized and specific to the individual.


Nishan Tchekmedyian, M .D., has been recognized by Greater Newport Physicians, a group that named him New Physician of the Year in 2017 and Specialist of the Year in 2019, 2020 and 2021 for his high-quality, patient-focused care.
Surgical Oncology


Dr. Cory Hugen, M.D. M.S., is a renowned urologic researcher and clinician. He has been the lead or co-investigator on dozens of clinical trials in addition to being a multi-decorated physician serving in the United States Air Force.
Medical Oncology


Sandy Liu, M.D., has made it her mission to improve the lives of cancer patients by taking care of people in a meaningful way and advancing the field of medical oncology as a clinical researcher. She makes sure to treat all of her patients as though they were members of her own family.


Fluent in Mandarin, Luke Chen, M.D., has helped cancer patients in Southern California for nearly 20 years. Focused on both saving life and improving quality of life, he treats his patients as family and is inspired by their courage and humility.


Sumanta (Monty) Kumar Pal, M.D., FASCO, is an internationally recognized leader in the area of genitourinary cancers, including kidney, bladder, and prostate cancer. He is co-director of City of Hope's Kidney Cancer Program and is the head of the kidney and bladder cancer disease team at the institution.
Radiation Oncology


For radiation oncologist Percy Lee, M.D., patients’ needs come first. He works closely with experts from other disciplines to offer each person an individually tailored treatment plan based upon both their clinical history and their emotional and social needs.


As a radiation oncologist, Dr. Julius Weng is dedicated to providing personalized, state-of-the-art treatment tailored to each patient’s physical and emotional needs.
Interventional Radiology


For Jason Salsamendi, M.D., patient care is a partnership where his role is to help people make informed decisions that best meet their needs.
Supportive Care


Richard T. Lee, M.D., is a third-generation physician who was inspired by seeing the positive impact that good health care can have on a community. His philosophy as an oncologist is all about treating the whole patient — centering care on who they are and what they need.


Jessica Cheng, M.D., is among the nation’s few, and Orange County’s only, fellowship-trained experts in cancer rehabilitation medicine. This is a subspecialty of physical medicine and rehabilitation (PM&R) also known as physiatry.