Radiation Oncology Research

City of Hope's Radiation Oncology Department is on the forefront of improving patient care, and our staff is constantly studying new technologies and treatment methods that can lead to better outcomes and quality of life for our patients.

Our research priorities include:

  • Enhancing radiation delivery so that it is more precise and focused on the tumor, improving its effectiveness against cancer cells while minimizing exposure to healthy tissue
  • Improving tumor visualization so that treatments can be planned with greater accuracy
  • Bridging and combining our imaging and treatment delivery technologies, so radiation therapy can be adjusted in realtime for maximal safety and effectiveness
  • Optimizing combination therapies so that radiation given sequentially or concurrently with other treatment modalities (such as surgery and drug therapy) can lead to better outcomes for the patient
  • Minimizing and mitigating radiation side effects to improve our patients' quality of life during and after treatment

Our department conducts a large number of clinical studies, and City of Hope patients may eligible for these novel therapies. Our current open clinical trials include:

Biomarker studies

  • 14266: Optimization of Gene Expression Biomarkers and Bioassay for Radiation Biodosimetry
  • 14238: Pilot Study: Detection of Carcinomas Using 64Cu-Labeled M5A Antibody to Carcinoembryonic Antigen(CEA)

Bone Metastases

  • 12212: A Feasibility Study to Evaluate the Safety and Initial Effectiveness of ExAblate MR  Guided Focused Ultrasound Surgery in the Treatment of Pain Resulting from Metastatic Bone  Tumors with the ExAblate 2100  Conformal Bone System
  • 13237: A Phase IV Post Approval Clinical Study of ExAblate Treatment of Metastatic Bone Tumors for the Palliation of Pain
  • 13238: A Post Approval Registry: ExAblate Treatment of Metastatic Bone Tumors for the Palliation of Pain

Functional Imaging

  • 13260: Changes in Multiparametric MRI Parameters Following Stereotactic Ablative Radiotherapy in Early Stage Non-Small Cell Lung Cancer: Pilot Study
  • 13398: A Pilot Study of Functional MRI to Evaluate Neurocognition After Brain Radiation

Head & Neck Cancers

  • 14145: Phase II Randomized Trial of Transoral Surgical Resection Followed by Low-dose or Standard-dose IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer
  • 14255: STAT3 Signaling During Chemo-Radiation for Squamous Cell Carcinoma of the Head and Neck
  • 14258: Randomized Phase II and Phase III Studies of Individualized Treatment for Nasopharyngeal Carcinoma Based on Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA)

Lung Cancer

  • 13260: Changes in Multiparametric MRI Parameters Following Stereotactic Ablative Radiotherapy in Early Stage Non-Small Cell Lung Cancer: Pilot Study

Multiple Myeloma

  • 07173: Correlating Organ Dose and Dose-Volume with Toxicities After Total Marrow Irradiation (TMI) Using Helical Tomotherapy in Patients Undergoing Hematopoietic Cell Transplantation (HCT)

Prostate Cancer

  • 12210: Focal MR-Guided Focused Ultrasound Treatment of Localized Low-Risk Prostate Cancer: Feasibility Study
  • 13257: Stereotactic Body Radiation Therapy to the Prostate Fossa: Phase I Dose Escalation Study

Stereotactic Body Radiotherapy (SBRT)

  • 13257: Stereotactic Body Radiation Therapy to the Prostate Fossa: Phase I Dose Escalation Study
  • 13260: Changes in Multiparametric MRI Parameters Following Stereotactic Ablative Radiotherapy in Early Stage Non-Small Cell Lung Cancer: Pilot Study
  • 14297: A Phase I Study of Stereotactic Body Radiotherapy (SBRT) for the Treatment of Multiple Metastases

Total Marrow Irradiation (TMI)

  • 07173: Correlating Organ Dose and Dose-Volume with Toxicities After Total Marrow Irradiation (TMI) Using Helical Tomotherapy in Patients Undergoing Hematopoietic Cell Transplantation (HCT)

For more information on a specific clinical trial or to sign up, please call 626-218-1133. You can also visit our Clinical Trials FAQs page to learn more about clinical trials program at City of Hope.