An NCI-designated Comprehensive Cancer Center

Defu Zeng

Professor, Department of Diabetes Immunology
Clinical Expertise
  • Diabetes immunology/autoimmunity
  • Hematology & hematopoietic cell transplantation
  • In vivo beta cell regeneration
Research Focus
  • Transplantation immune tolerance: mixed chimerism
  • Beta cell regeneration in diabetic mice
  • GVHD and GVL effect
Email: [email protected]

Research Teams


City of Hope Comprehensive Cancer Center, 1500 East Duarte Road

Duarte, CA 91010

Selected List of Publications
Zhang M, Racine JJ, Lin Q, Liu Y, Tang S, Qin Q, Qi T, Riggs AD, Zeng D (2018). MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2329-E2337. doi: 10.1073/pnas.1720169115. Epub 2018 Feb 20.
Zeng D (2018). Newly found arsons ignite the fire of gut GVHD. J Clin Invest. 2018 Mar 1;128(3):897-899. doi: 10.1172/JCI98685. Epub 2018 Jan 29.
Deng R, Hurtz C, Song Q, Yue C, Xiao G, Yu H, Wu X, Muschen M, Forman S, Martin PJ, Zeng D (2017). Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease. Nat Commun. 2017 Oct 17;8(1):978. doi: 10.1038/s41467-017-00880-2.
Zeng D. Bridge between type 1 diabetes in mouse and man. Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):10821-10823. doi: 10.1073/pnas.1715058114. Epub 2017 Oct 2
Ni X, Song Q, Cassady K, Deng R, Jin H, Zhang M, Dong H, Forman S, Martin PJ, Chen YZ, Wang J, Zeng D (2017). PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells. J Clin Invest. 2017 May 1;127(5):1960-1977. doi: 10.1172/JCI91138. Epub 2017 Apr 17.
Jin H, Ni X, Deng R, Song Q, Young J, Cassady K, Zhang M, Forman S, Martin PJ, Liu Q, Zeng D (2016). Antibodies from donor B cells perpetuate cutaneous chronic graft-versus-host disease in mice. Blood. 2016 May 5;127(18):2249-60. doi: 10.1182/blood-2015-09-668145. Epub 2016 Feb 16.
Zhang M, Lin Q, Qi T, Wang T, Chen CC, Riggs AD, Zeng D (2016). Growth factors and medium hyperglycemia induce Sox9+ ductal cell differentiation into β cells in mice with reversal of diabetes. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):650-5. doi: 10.1073/pnas.1524200113. Epub 2016 Jan 5.
Wu L, Li N, Zhang M, Xue SL, Cassady K, Lin Q, Riggs AD, Zeng D (2015). MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15994-9. doi: 10.1073/pnas.1521157112. Epub 2015 Dec 8.
Deng R, Cassady K, Li X, Yao S, Zhang M, Racine J, Lin J, Chen L, Zeng D (2015). B7H1/CD80 interaction augments PD-1-dependent T cell apoptosis and ameliorates graft-versus-host disease. J Immunol. 2015 Jan 15;194(2):560-74. doi: 10.4049/jimmunol.1402157. Epub 2014 Dec 8.
Racine JJ, Zhang M, Wang M, Morales W, Shen C, Zeng D (2015). MHC-mismatched mixed chimerism mediates thymic deletion of cross-reactive autoreactive T cells and prevents insulitis in nonobese diabetic mice. J Immunol. 2015 Jan 1;194(1):407-17. doi: 10.4049/jimmunol.1401584. Epub 2014 Nov 26.
Wang M, Racine J, Zhang M, Wu T, Deng R, Johnston H, Shen C, Siswanto K, Zeng D (2014). MHC-mismatched chimerism is required for induction of transplantation tolerance in autoimmune nonobese diabetic recipients. J Immunol. 2014 Aug 15;193(4):2005-15. doi: 10.4049/jimmunol.1401137. Epub 2014 Jul 7.
Johnston HF, Xu Y, Racine JJ, Cassady K, Ni X, Wu T, Chan A, Forman S, Zeng D (2014). Administration of anti-CD20 mAb is highly effective in preventing but ineffective in treating chronic graft-versus-host disease while preserving strong graft-versus-leukemia effects. Biol Blood Marrow Transplant. 2014 Aug;20(8):1089-103. doi: 10.1016/j.bbmt.2014.04.028. Epub 2014 May 4.
Zeng D (2014). Regulators help new immigrants settle down? Blood. 2014 May 1;123(18):2754-6. doi: 10.1182/blood-2014-03-562173.
He W, Racine JJ, Johnston HF, Li X, Li N, Cassady K, Liu C, Deng R, Martin P, Forman S, Zeng D (2014). Depletion of host CCR7(+) dendritic cells prevented donor T cell tissue tropism in anti-CD3-conditioned recipients. Biol Blood Marrow Transplant. 2014 Jul;20(7):920-8. doi: 10.1016/j.bbmt.2014.03.029. Epub 2014 Mar 30.
Racine JJ, Wang M, Zhang M, Zeng D (2014). Induction of mixed chimerism depletes pre-existing and de novo-developed autoreactive B cells in autoimmune NOD mice. Diabetes. 2014 Jun;63(6):2051-62. doi: 10.2337/db13-1532. Epub 2014 Jan 23
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