Don J. Diamond, Ph.D.

  • Chair and Professor, Department of Experimental Therapeutics

Don J. Diamond, Ph.D.

Research Focus :
  • Cancer and Viral Vaccines

Don J. Diamond, Ph.D., chairs the Department of Experimental Therapeutics, which develops vaccines to combat hematologic malignancies, solid tumors, and infectious pathogens such as the herpesvirus, cytomegalovirus (CMV) HIV.

The prospect of an effective CMV vaccine means significant benefits for immunocompromised patients such as those with AIDS, or stem cell and solid organ transplant recipients.  A therapeutic CMV peptide vaccine developed in the department is undergoing phase II human efficacy testing in City of Hope stem cell transplant recipients, while a second generation CMV vaccine based on the attenuated poxvirus MVA, or modified vaccinia Ankara, is currently undergoing phase I human safety testing.

A vaccine developed in the department also based on the MVA platform expressing unmutated p53 has completed phase I human testing in City of Hope gastrointestinal cancer patients.  In the laboratory, we are refining a therapeutic platform based on attenuated Salmonella bacterium to treat a range of malignancies including pancreatic, skin and brain cancers.  In collaboration with Peter Barry, Ph.D., of University of California at Davis and the National Primate Research Center, we are developing a prophylactic CMV vaccine that promises to control gestational infection that causes a wide range of birth defects that annually afflict close to 4,000 American children.

  • 2014 - Present, Chair and Professor, Department of Experimental Therapeutics
  • 2013 - 2014, Associate Chair, Department of Virology
  • 2008 - 2014, Director, Division of Translational Vaccine Research, Beckman Research Institute of City of Hope, Duarte, CA
  • 1999 - 2014, Professor, Department of Virology, Beckman Research Institute
  • 1999 - 2008, Head, Laboratory of Vaccine Research, Department of Virology, Beckman Research Institute
  • 1994 - 1999, Associate Research Scientist, Hematology Research, City of Hope, Duarte, CA
  • 1989 - 1994, Assistant Research Scientist and Section Head, Department of Immunology, Beckman Research Institute of City of Hope, Duarte, CA
  • 1986 - 1989, Research Fellow and Instructor in Pathology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA
  • 1985 - 1987, Leukemia Society of America Fellow with E. Reinherz, M.D., DFCI, Harvard Medical School, Boston, MA
  • 1984 - 1986, Postdoctoral Fellow with S. Tonegawa, Ph.D., Center for Cancer Research, MA, MIT, Cambridge, MA
  •     1984, Harvard Medical School, Boston, Massachusetts, Ph.D., Biological Chemistry
  •     1977, Harvard University, Cambridge, Massachusetts, A.B., Biology (Magna Cum Laude)

Project 1:  Phase 1b And Phase 2 Evaluation Of Protective Efficacy, Safety And Correlative Immunogenicity Studies Of Cmvpepvax Co-Injected With Pf03512676 Adjuvant In Recipients Of Allogeneic Stem Cell Transplant
 
Project 2:  Control Of Cmv Infection In Allogeneic Stem Cell Transplant Recipients Using Attenuated Mva-Based Cmv Subunit Vaccine
 
Project 3:  Phase I Study Of A P53-Mva Vaccine For Advanced Colon, Gastric And Pancreatic Cancer
 
Project 4:  Development Of Vaccine Strategies To Prevent Congenital Cytomegalovirus Infection
 
Project 5:  Ido-Silencing Salmonella Therapy For The Treatment Of Primary And Metastatic Pdac
 
Project 6:  Pilot Project - Blockade Of Immune Checkpoint Receptors For The Treatment Of Pancreatic Cancer

The Laboratory of Vaccine Research (LVR) was originally formed by  Don J. Diamond, Ph.D. in 2000 to address priorities in vaccine research that would potentially impact patient outcomes at the City of Hope (COH) and other cancer centers worldwide.  The LVR later evolved into the Division of Translational Vaccine Research (TVR) in 2008, which has, since then, focused on the clinical translation of vaccine and therapeutic strategies to combat herpes viral infections, hematologic malignancies, and solid tumors. Our comprehensive program has now developed molecular vaccines and therapies that incorporate various technologies such as peptides and viral or bacterial vectors to directly elicit, or encode antigens that elicit, viral- or cancer-specific immune responses. Currently, the TVR has produced several agents that have advanced beyond pre-clinical testing into Phase I and II trials. The mission of the TVR is to continue progress in the development and testing of treatments with clinical benefit for cancer patients.  In 2014, the TVR was transformed into the Department of Experimental Therapeutics (ET).  The mission of the ET department will encompass the work of the TVR and broaden its scope to include more basic studies in basic and tumor immunology.

Learn more.

 
 
 
 
Nicola Hardwick, Ph.D.
Regulatory Affairs Specialist
[email protected]
 
Angelina Iniguez
Research Associate II
[email protected]
 
 
 
 
 
 
Postdoctoral Fellow
 
Joybelle Martinez
Senior Research Associate
[email protected]
 
Aline Matsuo, Ph.D.
Senior Administrative Support
[email protected]
 
Zhuo Meng, M.D.
Research Assistant II
[email protected]
 
 
 
 
 
Weimin Tsai
Research Associate II
Department of Hematology
[email protected]
 
Qiao Zhou
Research Associate II
[email protected]
Vaccine Therapies for Cancer - Don J. Diamond, Ph.D.
Vaccine Therapies for Cancer - Don J. Diamond, Ph.D.

Vaccine Therapies for Cancer - Don J. Diamond, Ph.D.

August 11, 2015
  • Wussow F, Chiuppesi F, Zhuo M, Martinez J, Nguyen J, Barry PA, and Diamond DJ. A novel bacterial artificial chromosome of modified vaccinia Ankara allows robust neutralizing antibody induction by self-processing subunits of the human cytomegalovirus pentamer complex. Submitted, J. Virologic Methods, July 2017.
  • Chiuppesi F, Wussow F, Scharf L, Contreras H, Gao H, Zhuo M, Nguyen J, Barry PA, Bjorkman PJ, and Diamond DJ. Comparison of homologous and heterologous prime-boost vaccine approaches to induce neutralizing antibodies by the human cytomegalovirus pentamer complex in mice. PLoS, In Press, 2017.
  • Yuan Y, Kos FJ, He, TF, Yin HH, Li M, Hardwick N, Zurcher K, Schmolze D, Lee P, Pillai RK, Chung V, and Diamond DJ. Complete regression of cutaneous metastases with systemic immune response in a triple negative breast cancer patient receiving p53MVA vaccine with pembrolizumab. Oncoimmunology. In Press, 2017.
  • Nelson CS, Vera Cruz D, Tran D, Bialas KM, Stamper L, Wu H, Gilbert M, Blair R, Alvarez X, Itell H, Chen M, Deshpande A, Chiuppesi F, Wussow F, Diamond DJ, Vandergrift NA, Walter M, Cohen-Wolkowiez M, Barry PA, Koelle K, Kaur A, and Permar SR. Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys. JCI Insight 2(13):e94002. doi:10.1172/jci.insight.94002, 2017.
  • Won H, Moreira D, Gao C, Duttagupta P, Zhao X, Manuel E, Diamond DJ, Yuan YC, Liu Z, Jones J, D'Apuzzo M, Pal S, and Kortylewski M. TLR9 expression and secretion of LIF by prostate cancer cells stimulates accumulation and activity of polymorphonuclear MDSCs. J Leukoc Biol, doi: 10.1189/jlb.3MA1016-451RR, 2017. PMID: 28533357
  • Melstrom L, Salazar, MD, and Diamond DJ. The pancreatic cancer microenvironment: a true double agent. J Surg Oncol 116(1):7-15, 2017. PMID: 28605029
  • Fan Q, Nelson CS, Bialas KM, Chiuppesi F, Amos J, Gurley TC, Marshall DJ, Eudailey J, Heimsath H, Himes J, Deshpande A, Water MR, Wussow F, Diamond DJ, Barry PA, Moody MA, Kaur A, and Permar SR. Plasmablast response to primary rhesus cytomegalovirus infection in a monkey model of congenital CMV transmission. Clin Vaccine Immunol, 24(5). Pii:e00510-16, doi:10.1128/CVI.00510-16. PMID: 28298291
  • Chiuppesi F, Kaltcheva T, Zhuo M, Barry PA, Diamond DJ and Wussow F. Identification of a continuous neutralizing epitope within UL128 of human cytomegalovirus. J Virol 91(6):e01857-16, doi: 10.1128/JVI.01857-16, 2017. PMID: 28077639
  • La Rosa C, Longmate J, Martinez J, Zhou Q, Kaltcheva TI, Tsai W, Drake J, Carroll M, Wussow F, Chiuppesi F, Hardwick N, Dadwal S, Aldoss I, Nakamura R, Zaia JA, and Diamond DJ.  MVA vaccine encoding CMV antigens safely induces durable expansion of CMV-specific T cells in healthy adults. Blood 129(1):114-125, 2017. PMID: 27760761
  • Yue Y, Kaur A, Lilja A, Diamond DJ, Walter MR, and Barry PA. The susceptibility of primary cultured rhesus macaque kidney epithelial cells to rhesus cytomegalovirus strains. J Gen Virol 97(6):1426-1438, 2016. PMID: 26974598
  • D'Alincourt Salazar, M, Manuel ER, Tsai W, D'Apuzzo M, Goldstein L, Blazar BR, and Diamond DJ.  Evaluation of innate and adaptive immunity contributing to the antitumor effects of PD1 blockade in an orthotopic murine model of pancreatic cancer. Oncoimmunology 5(6):e1160184, 2016. PMID: 27471630
  • Chen J, Diamond DJ, and Manuel ER. Developing effective Salmonella-based approaches to treat pancreatic cancer. Pancreat Disord Ther 6(1):1-2, 2016. PMID: 26925306
  • Nakamura R, La Rosa C, Longmate J, Drake J, Slape C, Zhou Q, Lampa MG, O'Donnell M, Cai JL, Farol L, Salhotra A, Snyder DS, Aldoss I, Forman SJ, Miller JS, Zaia JA, and Diamond DJ. Viraemia, immunogenicity, and survival outcomes of cytomegalovirus chimeric epitope vaccine supplemented with PF03512676 (CMVPepVax) in allogeneic haematopoietic stem-cell transplantation: randomised phase 1b trial. Lancet Haematol 3(2):e87-98, 2016. PMID: 26853648
  • Limaye AP, La Rosa C Longmate J, and Diamond DJ. Plasma IL-10 levels to guide antiviral prophylaxis prevention of late-onset cytomegalovirus disease. Transplantation 100(1):210-216, 2016. PMID: 26680375
  • Cichocki F, Cooley S, Davis Z, DeFor TE, Schlums H, Zhang B, Brunstein CG, Blazar BR, Wagner J, Diamond DJ, Verneris MR, Bryceson YT, Weisdorf DJ, and Miller JS. CD56dimCD57+NKG2C+ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT. Leukemia 30(2):456-463, 2016. PMID: 26416461
  • Bialas KM, Tanaka T, Tran D, Varner V, Cisneros De La Rosa E, Chiuppesi F, Wussow F, Kattenhorn L, Macri S, Kunz EL, Estroff JA, Kirchherr J, Yue Y, Fan Q, Lauck M, O'Connor DH, Hall AHS, Xavier A, Diamond DJ, Barry PA, Kaur A, and Permar S.  Maternal CD4+ T cells protect against severe congenital cytomegalovirus disease in a novel nonhuman primate model of placental cytomegalovirus transmission. Proc Natl Acad Sci 112(44):13645-13650, 2015. PMID: 26483473
  • Chiuppesi F, Wussow F, Johnson E, Bian C, Zhuo M, Rajakumar A, Barry PA, Britt WJ, Chakraborty R, and Diamond DJ. Vaccine-derived neutralizing antibodies to the human cytomegalovirus gH/gL pentamer potently block primary cytotrophoblast infection. J Virol 89(23):1184-1198, 2015. PMID: 26378171
  • Manuel ER, Chen J, D'Apuzzo M, Lampa MG, Kaltcheva TI, Thompson CB, Ludwig T, Chung V, and Diamond DJ. Salmonella-based therapy targeting indoleamine 2,3-dioxygenase coupled with enzymatic depletion of tumor hyaluronan induces complete regression of aggressive pancreatic tumors. Cancer Immunol Res 3(9):1096-1107, 2015. PMID: 26134178
  • Swanson EC, Gillis P, Hernandez-Alvarado N, Fernández-Alarcón C, Schmit M, Zabeli JC, Wussow F, Diamond DJ, and Schleiss MR. Comparison of monovalent glycoprotein B with bivalent gB/pp65 (GP83) vaccine for congenital cytomegalovirus infection in a guinea pig model: inclusion of GP83 reduces antibody response but both vaccine approaches provide equivalent protection against pup mortality. Vaccine 33(32):4013-4018, 2015. PMID: 26079615
  • Davis ZB, Cooley SA, Cichocki F, Felices M, Wangen R, Luo X, DeFor TE, Bryceson YT, Diamond DJ, Brunstein C, Blazar BR, Wagner JE, Weisdorf DJ, Horowitz A, Guethlein LA, Parham P, Verneris MR,  and Miller JS. Adaptive NK cell and killer cell immunoglobulin-like receptor-expressing T cell responses are induced by cytomegalovirus and are associated with protection against cytomegalovirus reactivation after allogeneic donor hematopoietic cell transplantation. Biol Blood Marrow Transplant 21(9):1653-1662, 2015. PMID: 26055301
  • Wang X, Wong CW, Urak R, Mardiros A, Budde LE, Chang WC, Thomas SH, Brown CE, La Rosa C, Diamond DJ, Jensen MC, Nakamura R, Zaia JA, and Forman SJ. CMVpp65 vaccine enhances the antitumor efficacy of adoptively transferred CD19-redirected CMV-specific T cells. Clin Cancer Res 21(13):2993-3002, 2015. PMID: 25838392
  • Weiman S (main author), Diamond DJ (co-author), et al.  Harnessing the Power of Microbes as Therapeutics: Bugs as Drugs. American Academy of Microbiology Colloquium Report, 28pp, 2015.
  • Gibson L, Barysauskas CM, McManus M, Dooley S, Lilleri D, Fisher D, Srivastava T, Diamond DJ, and Luzuriaga K. Reduced frequencies of polyfunctional CMV-specific T cell responses in infants with congenital CMV infection. J Clin Immunol 35(3):289-301, 2015. PMID: 25712611
  • Israyelyan A, Goldstein L, Tsai W, Aquino L, Forman SJ, Nakamura R, and Diamond DJ. Real-time assessment of relapse risk based on the WT1 marker in acute leukemia and myelodysplastic syndrome patients after hematopoietic cell transplantation. Bone Marrow Transplant 50(1):26-33, 2015. PMID: 25243629
  • Xu X, Hegazy WAH, Guo L, Gao X, Courtney AN, Kurbanov S, Liu D, Tian G, Manuel ER, Diamond DJ, Hensel M, and Metelitsa LS. Effective cancer vaccine platform based on attenuated Salmonella and a type III secretion system. Cancer Res 74(21):6260-6270, 2014. PMID: 25213323
  • Hardwick N, Chung V, Cristea M, Ellenhorn JDI, and Diamond DJ. Overcoming immunosuppression to enhance a p53MVA vaccine: Oncoimmunology 3(10):e958949, 2014. PMID: 25941580
  • Wussow F, Chiuppesi F, Martinez J, Campo J, Johnson E, Flechsig C, Newell M, Tran E, Ortiz J, La Rosa C, Herrmann A, Longmate J, Chakraborty R, Barry PA, and Diamond DJ. Human cytomegalovirus vaccine based on the envelope gH/gL pentamer complex. PLoS Pathog 10(11):e1004524, 2014. PMID: 25412505
  • Hardwick NR, Carroll M, Kaltcheva T, Qian D, Lim D, Leong L, Chu P, Kim J, Chao J, Fakih M, Yen Y, Espenschied J, Ellenhorn JDI, Diamond DJ, and Chung V. p53MVA therapy in patients with refractory gastrointestinal malignancies elevates p53-specific CD8+ T-cell responses. Clin Cancer Res 20(17):4459-4470, 2014. PMID: 24987057
  • Gillis PA, Hernandez-Alvarado N, Gnanandarajah JS, Wussow F, Diamond DJ, Schleiss MR. Development of a novel, guinea pig-specific IFN-? ELISPOT assay and characterization of guinea pig cytomegalovirus GP83-specific cellular immune responses following immunization with a modified vaccinia Ankara (MVA)-vectored GP83 vaccine. Vaccine 32(31):3963-3970, 2014. PMID: 24856783
  • Nakamura R, La Rosa C, Tsai W, Lacey SF, Srivastava T, Seidel A, Senitzer D, Forman SJ, and Diamond DJ. Ex vivo detection of CD8 T cells specific for H-Y minor histocompatibility antigens in allogeneic hematopoietic stem cell transplant recipients. Transpl Immunol 30(4):128-135, 2014. PMID: 24582729
  • Gao C, Kozlowska A, Nechaev S, Li H, Zhang Q, Hossain DMS, Kowolik CM, Chu P, Swiderski P, Diamond DJ, Pal SK, Raubitschek A, and Kortylewski M. TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy. Cancer Res 73(24):7211-7221, 2013. PMID: 24154870
  • Gil A, Shen S, Coley S, Gibson L, Diamond DJ, Wang S, and Lu S. DNA vaccine prime followed by boost with live attenuated virus significantly improves antigen-specific T cell responses against human cytomegalovirus. Hum Vaccin Immunother 9(10): 2120-2132, 2013. PMID: 24051429
  • Manuel ER, Blazar BR and Diamond DJ. Tumor growth control with IDO-silencing Salmonella - Reply. Cancer Res 73(14):4592-4593, 2013. PMID: 23832663
  • Israyelyan A, La Rosa C, Tsai W, Kaltcheva T, Srivastava T, Aquino L, Li J, Kim Y, Palmer J, Streja L, Senitzer D, Zaia JA, Rosenwald A,Forman SJ, Nakamura R, and Diamond DJ. Detection and preliminary characterization of CD8+ T lymphocytes specific for Wilms' tumor antigen in patients with non-Hodgkin lymphoma. Leuk Lymphoma 54(11):2490-2499, 2013. PMID: 23480492
  • Manuel ER and Diamond DJ. A road less traveled paved by IDO silencing: harnessing the antitumor activity of neutrophils. Oncoimmunology 2(3):e23322, 2013.  PMID: 23802075
  • Wussow F, Yue Y, Martinez J, Deere JD, Longmate J, Herrmann A, Barry PA, Diamond DJ. A vaccine based on the rhesus cytomegalovirus UL128 complex induces broadly neutralizing antibodies in rhesus macaques. J Virol 87(3):1322-1332, 2013.  PMID: 23152525
  • Blache CA, Manuel ER, Kaltcheva TI, Wong AN, Ellenhorn JDI, Blazar BR, and Diamond DJ. Systemic delivery of Salmonella typhimurium transformed with IDO shRNA enhances intratumoral vector colonization and suppresses tumor growth.  Cancer Res 72(24):6447-6456, 2012. PMID: 23090116
  • Fan H, Zhang I, Chen X, Zhang L, Wang H, Da Fonseca A, Manuel ER, Diamond DJ, Raubitschek A, and Badie B. Intracerebral CpG immunotherapy with carbon nanotubes abrogates growth of subcutaneous melanomas in mice. Clin Cancer Res 18(20):5628-5638, 2012. PMID: 22904105
  • Assaf BT, Mansfield KG, Westmoreland SV, Kaur A, Oxford KL, Diamond DJ, and Barry PA. Patterns of acute rhesus cytomegalovirus (RhCMV) infection predict long-term RhCMV infection. J Virol 86(11):6354-6357, 2012. PMID: 22491451
  • La Rosa C, Longmate J, Lacey SF, Kaltcheva T, Sharan R, Marsano D, Kwon P, Drake J, Williams B, Denison S, Broyer S, Couture L, Nakamura R, Dadwal S, Kelsey MI, Krieg AM, Diamond DJ, and Zaia JA. Clinical evaluation of safety and immunogenicity of PADRE-cytomegalovirus (CMV) and tetanus-CMV fusion peptide vaccines with or without PF03512676 adjuvant. J Infect Dis 205(8):1294-1304, 2012. PMID: 22402037
  • La Rosa C and Diamond DJ. The immune response to human CMV.  Future Virol 7(3):279-293, 2012. PMID: 23308079
  • Manuel ER, Blache CA, Ellenhorn JDI, and Diamond DJ. Survivin the battle against immunosuppression. Oncoimmunology 1(2):240-241, 2012. PMID: 22720256
  • Song GY, Srivastava T, Ishizaki H, Lacey SF, Diamond DJ, and Ellenhorn JDI. Recombinant modified vaccinia virus Ankara (MVA) expressing wild type human p53 induces specific antitumor CTL expansion. Cancer Invest 29(8):501-510, 2011. PMID: 21843052
  • Oxford KL, Strelow L, Yue Y, Chang WL, Schmidt KA, Diamond DJ, and Barry PA. Open reading frames carried on UL/b' are implicated in shedding and horizontal transmission of rhesus cytomegalovirus in rhesus monkeys. J Virol 85(10):5105-5114, 2011. PMID: 21389128
  • La Rosa C, Limaye AP, Krishnan A, Blumstein G, Longmate J, and Diamond DJ. Primary response against cytomegalovirus during antiviral prophylaxis with valganciclovir, in solid organ transplant recipients. Transpl Int 24(9):920-931, 2011.  PMID: 21672050
  • Lacey SF, La Rosa C, Kaltcheva T, Srivastava T, Seidel A, Zhou W, Rawal R, Hagen K, Krishnan A, Longmate J, Andersson HA, St. John L, Bhatia R, Pullarkat V, Forman SJ, Cooper LJN, Molldrem J, and Diamond DJ. Characterization of immunologic properties of a second HLA-A2 epitope from a granule protease in CML patients and HLA-A2 transgenic mice. Blood 118(8):2159-2169, 2011. PMID: 21719601
  • Manuel ER, Blache CA, Paquette R, Kaltcheva TI, Ishizaki H, Ellenhorn JDI, Hensel M, Metelitsa L, and  Diamond DJ. Enhancement of cancer vaccine therapy by systemic delivery of a tumor-targeting Salmonella-based STAT3 shRNA suppresses the growth of established melanoma tumors. Cancer Res 71(12):4183-4191, 2011. PMID: 21527558
  • Zhao D, Alizadeh D, Zhang L, Liu W, Farrukh O, Manuel E, Diamond DJ, and Badie B. Carbon nanotubes enhance CpG uptake and potentiate antiglioma immunity. Clin Cancer Res 17(4):771-782, 2011. PMID: 21088258
  • Ishizaki H, Manuel ER, Song GY, Srivastava T, Sun S, Diamond DJ, and Ellenhorn JDI. Modified vaccinia Ankara expressing survivin combined with gemcitabine generates specific antitumor effects in a murine pancreatic carcinoma model. Cancer Immunol Immunother 60(1):99 -109, 2011.  PMID: 20960189
  • Abel K, Martinez J, Yue Y, Lacey SF, Wang Z, Strelow L., Dasgupta A, Li Z, Schmidt  KA, Oxford KL, Assaf B, Longmate JA, Diamond DJ, and Barry PA. Vaccine-Induced control of viral shedding following rhesus cytomegalovirus challenge in rhesus macaques. J Virol 85(6):2878-2890, 2011. PMID: 21191005
  • Seidel A, Smith D, Yung E, Aquino L, Srivastava T, Pullarkat V, Spielberger R, Forman SJ and Diamond DJ. CD154 expression is associated with neutralizing antibody titer against postinfluenza vaccination in stem cell transplant patients and healthy adults. Biol Blood Marrow Transplant 17(4):524-533, 2011. PMID: 20457264
  • Ishizaki H, Song GY, Srivastava T, Carroll KD, Shahabi V, Manuel ER, Diamond DJ, and Ellenhorn JDI. Heterologous prime/boost immunization with p53-based vaccines combined with toll-like receptor stimulation enhances tumor regression. J Immunother 33(6):609-617, 2010. PMID: 20551836
  • Manuel ER, Wang Z, Li Z, La Rosa C, Zhou W, and Diamond DJ. Intergenic region 3 of modified vaccinia Ankara is a functional site for insert gene expression and allows for potent antigen-specific immune responses. Virology 403(2):155-162, 2010. PMID: 20471051
  • Althoff KN, Anastos K, Nelson KE, Celentano DD, Sharp GB, Greenblatt RM, French AL, Diamond DJ, Holman S, Young M, and Gange SJ. Predictors of reported influenza vaccination in HIV-infected women in the United States, 2006-2007 and 2007-2008 seasons. Prev Med 50(5-6):223-229, 2010. PMID: 20303362
  • Krishnan A, Zhou W, Lacey SF, Limaye AP, Diamond DJ, and La Rosa C. Programmed death-1 and interleukin-10 in liver transplant recipients at high risk for late cytomegalovirus disease. Transpl Infect Dis 12(4):363-370, 2010. PMID: 20070620
  • Wang Z, Martinez J, Zhou W, La Rosa C, Srivastava T, Dasgupta A, Rawal R, Li Z, Britt WJ, and Diamond DJ. Modified H5 promoter improves stability of insert genes while maintaining immunogenicity during extended passage of genetically engineered MVA vaccines. Vaccine 28(6):1547-1557, 2010. PMID: 19969118
  • Zhou W, Longmate J, Lacey SF, Palmer JM, Gallez-Hawkins G, Thao L, Spielberger R, Nakamura R, Forman SJ, Zaia JA, and Diamond DJ. Impact of donor CMV status on viral infection and reconstitution of multifunction CMV-specific T cells in CMV-positive transplant recipients. Blood 113(25):6465-6476, 2009. PMID: 19369230
  • Gallez-Hawkins GM, Thao L, Palmer J, Dagis A, Li X, Franck AE, Tegtmeier B,  Lacey SF, Diamond DJ, Forman SJ, and Zaia JA. Increased programmed death-1 molecule expression in CMV disease and acute graft-versus-host disease after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 15(7):872-880, 2009. PMID: 19539220
  • Zaia JA, Sun JY, Gallez-Hawkins GM, Thao L, Oki A, Lacey SF, Dagis A, Palmer J, Diamond DJ, Forman SJ, and Senitzer D. The effect of single and combined activating killer immunoglobulin-like receptor genotypes on cytomegalovirus infection and immunity after hematopoietic cell transplant. Biol Blood Marrow Transplant 15(3):315-325, 2009. PMID: 19203722
  • Li J, Srivastava T, Rawal R, Manuel E, Isbell D, Tsark W, La Rosa C, Wang Z, Li Z, Barry PA, Hagen KD, Longmate J, and Diamond DJ. Mamu-A*01/Kb transgenic and MHC Class I knockout mice as a tool for HIV vaccine development. Virology  387(1):16-28, 2009. PMID: 19249807
  • Krishnan A, Wang Z, Srivastava T, Rawal R, Manchanda P, Diamond DJ, and La Rosa C. A novel approach to evaluate the immunogenicity of viral antigens of clinical importance in HLA transgenic murine models.  Immunol Lett 120(1-2):108-116, 2008. PMID: 18706443
  • Wang Z, Zhou W, Srivastava T, La Rosa C, Mandarino A, Forman SJ, Zaia JA, Britt WJ, and Diamond DJ. A fusion protein of HCMV IE1 exon4 and IE2 exon5 stimulates potent cellular immunity in an MVA vaccine vector. Virology 377(2):379-390, 2008. PMID: 18538366
  • Yue Y, Wang Z, Abel K, Li J, Strelow L, Mandarino A, Eberhardt MK, Schmidt KA, Diamond DJ, and Barry PA. Evaluation of recombinant modified vaccinia Ankara virus-based rhesus cytomegalovirus vaccines in rhesus macaques. Med Microbiol Immunol 197(2):117-123, 2008. PMID: 18196272
  • La Rosa C, Krishnan A, Longmate J, Martinez J, Manchanda P, Lacey SF, Limaye AP and Diamond DJ. Programmed death-1 expression in liver transplant recipients as a prognostic indicator of cytomegalovirus disease. J Infect Dis 197(1):25-33, 2008. PMID: 18171281
  • Zhou W, Sharma M, Martinez J, Srivastava T, Diamond DJ, Knowles WA, Lacey SF. Functional characterization of BK virus-specific cytotoxic CD4+ T cells with cytotoxic potential in seropositive adults. Viral Immunol 20(3):379-388, 2007. PMID: 17931108
  • Margolin K, Synold, TW, Lara P, Frankel P, Lacey SF, Quinn DI, Baratta T, Dutcher JP, Xi B, Diamond DJ, and Gandara DR. Oblimersen and alpha-interferon in metastatic renal cancer: a phase II study of the California Cancer Consortium. J Cancer Res Clin Oncol 133(10):705-711, 2007. PMID: 17508219
  • La Rosa C, Limaye AP, Krishnan A, Longmate J, and Diamond DJ. Longitudinal assessment of cytomegalovirus (CMV)-specific immune responses in liver transplant recipients at high risk for late CMV disease. J Infect Dis 195(5):633-644, 2007. Editorial Commentary by Boeckh and Riddell in same issue (195(5):615-617). PMID: 17262704
  • Song GY, Gibson G, Haq W, Huang EC, Srivastava T, Hollstein M, Daftarian P, Wang Z, Diamond DJ, and Ellenhorn JDI. An MVA vaccine overcomes tolerance to human p53 in mouse and humans. Cancer Immunol Immun 56(8):1193-1205, 2007. PMID: 17219151
  • Wang Z, La Rosa C, Li Z, Ly H, Krishnan A, Martinez J, Britt WJ, and Diamond DJ. Vaccine properties of a novel marker gene-free recombinant modified vaccinia Ankara expressing immunodominant CMV antigens pp65 and IE1.  Vaccine 25(6):1132-1141, 2007. PMID: 17049414
  • Lacey SF, La Rosa C, Zhou W, Sharma MC, Martinez J, Krishnan A, Gallez-Hawkins G, Thao L, Longmate J, Spielberger R, Forman SJ, Limaye A, Zaia JA, and Diamond DJ. Functional comparison of T cells recognizing cytomegalovirus pp65 and intermediate-early antigen polypeptides in hematopoietic stem-cell transplant and solid organ transplant recipients. J Infect Dis 194(10):1410-1421, 2006. PMID: 17054071
  • Sharma MC, Zhou W, Martinez J, Krymskaya L, Srivastava T, Haq W,  Diamond DJ, and Lacey SF. Cross-reactive CTL recognizing two HLA-A*02-restricted epitopes within the BK virus and JC virus VP1 polypeptides are frequent in immunocompetent individuals. Virology  350(1):128-136, 2006. PMID: 16600320
  • La Rosa C, Wang Z, Lacey SF, Lalimarmo MM, Krishnan A, Longmate J, and Diamond DJ. In vitro expansion of polyclonal T-cells subsets for adoptive immunotherapy by recombinant modified vaccinia Ankara. Exp Hematol 34(4):497-507, 2006. PMID: 16569596
  • Wang Z, La Rosa C, Lacey SF, Maas R, Mekhoubad S, Britt WJ, and Diamond DJ.  Attenuated poxvirus expressing three immunodominant CMV antigens as a vaccine strategy for CMV infection. J Clin Virol 35(3):324-331, 2006. PMID: 16388983
  • Khanna, R and Diamond DJ. Human cytomegalovirus vaccine: time to look for alternative options. Trends Mol Med 12(1):26-33, 2006. PMID: 16337831
  • Gallez-Hawkins G, Thao L, Lacey SF, Martinez J, Li X, Franck AE, Lomeli NA, Longmate J, Diamond DJ, Speilberger R, Forman SJ, and Zaia JA. Cytomegalovirus immune reconstitution occurs in recipients of allogeneic hematopoietic cell transplants irrespective of detectable cytomegalovirus infection. Biol Blood Marrow Transplant 11(11):890-902, 2005. PMID: 16275592
  • Krymskaya L, Sharma MC, Martinez J, Haq W, Huang EC, Limaye AP, Diamond DJ, and Lacey SF. Cross-reactivity of T lymphocytes recognizing a human cytotoxic T-lymphocyte epitope within BK and JC virus VP1 polypeptides. J Virol 79 (17):11170-11178, 2005. PMID: 16103168
  • Lau SK, Chen YY, Chen WG, Diamond DJ, Mamelak AN, Zaia JA, and Weiss LM. Lack of association of cytomegalovirus with human brain tumors. Modern Pathol 18(6):838-843, 2005. PMID: 15578071
  • Daftarian P, Sharan R, Haq W, Ali S, Longmate J, Termini J, and Diamond DJ. Novel conjugates of epitope fusion peptides with CpG-ODN display enhanced immunogenicity and HIV recognition. Vaccine 23(26):3453-3468, 2005. PMID: 15837369
  • Lacey SF, Martinez J, Gallez-Hawkins G, Thao L, Longmate J, Haq W, Spielberger R, Forman SJ, Zaia JA, and Diamond DJ. Simultaneous reconstitution of multiple cytomegalovirus-specific CD8+ cell populations with divergent functionality in hematopoietic stem-cell transplant recipients. J  Infect Dis 191(6):977-984, 2005. PMID: 15717275
  • Villacres MC, Literat O, DeGiacomo M, Du W, La Rosa C, Diamond DJ, and Kovacs A. Reduced type 1 and type 2 cytokines in antiviral memory T helper function among women coinfected with HIV and HCV. J Clin Immunol 25(2):134-141, 2005. PMID: 15821890
  • La Rosa C, Wang Z, Lacey SF, Markel SF, Sharma MC, Martinez J, Lalimarmo MM, and Diamond DJ. Characterization of host immunity to cytomegalovirus pp150 (UL32). Hum Immunol 66(2):116-126, 2005. PMID: 15694996
  • Gallez-Hawkins G, Li X, Franck AE, Thao L, Lacey SF, Diamond DJ, and Zaia JA.  DNA and low titer, helper-free, recombinant AAV prime-boost vaccination for cytomegalovirus induces an immune response to CMV-pp65 and CMV-IE1 in transgenic HLA A*0201 mice. Vaccine 23(6):819-826, 2004. PMID: 15542207
  • Daftarian P, Song GY, Ali S, Faynsod M, Longmate J, Diamond DJ, and Ellenhorn JD. Two distinct pathways of immuno-modulation improve potency of p53 immunization in rejecting established tumors.  Cancer Res 64(15):5407-5414, 2004. PMID: 15289349
  • Wang Z, La Rosa C, Mekhoubad S, Lacey SF, Villacres MC, Markel S, Longmate J, Ellenhorn JD, Siliciano RF, Buck C, Britt WJ, and Diamond DJ. Attenuated poxviruses generate clinically relevant frequencies of CMV-specific T cells. Blood 104(3):847-856, 2004. PMID: 15090456
  • Lacey S, Diamond DJ, and Zaia JA. Assessment of cellular immunity to human cytomegalovirus in recipients of allogeneic stem cell transplants. Biol Blood Marrow Transplant 10(7):433-447, 2004. PMID: 15205665
  • Wang Z, La Rosa C, Maas R, Ly H, Brewer J, Mekhoubad S, Daftarian P, Longmate J, Britt WJ, and Diamond DJ. Recombinant modified vaccinia virus Ankara expressing a soluble form of glycoprotein B causes durable immunity and neutralizing antibodies against multiple strains of human cytomegalovirus. J Virol 78(8):3965-3976, 2004. PMID: 15047812
  • Villacres MC, Longmate J, Auge C, and Diamond DJ. Predominant type 1 CMV-specific memory T-helper response in humans: evidence for gender differences in cytokine secretion. Hum Immunol 65(5):476-485, 2004. PMID: 15172447
  • Gibson L, Piccinini G, Lilleri D, Revello MG, Wang Z, Markel S, Diamond DJ, Luzuriaga K. Human cytomegalovirus proteins pp65 and immediate early protein 1 are common targets for CD8+ T cell responses in children with congenital or postnatal human cytomegalovirus infection. J Immunol 172(4):2256-2264, 2004. PMID: 14764694
  • Daftarian P, Ali S, Sharan R, Lacey SF, La Rosa C, Longmate J, Buck C, Siliciano RF, and Diamond DJ. Immunization with Th-CTL fusion peptide and cytosine-phosphate-guanine DNA in transgenic HLA-A2 mice induces recognition of HIV-infected T cells and clears vaccinia virus challenge. J Immunol 171(8):4028-4039, 2003. PMID: 14530323
  • Villacres MC, Lacey SF, Auge C, Longmate J, Leedom JM, and Diamond DJ. Relevance of peptide avidity to the T cell receptor for cytomegalovirus-specific ex vivo CD8 T cell cytotoxicity.  J Infect Dis 188(6):908-918, 2003. PMID: 12964124
  • Lacey SF, Villacres MC, La Rosa C, Wang Z, Longmate J, Martinez J, Brewer JC, Mekhoubad S, Maas R, Leedom JM, Forman SJ, Zaia JA, and Diamond DJ. Relative dominance of HLA-B*07-restricted CD8+ T-lymphocyte immune responses to human cytomegalovirus pp65 in persons sharing HLA-A*02 and HLA-B*07 alleles. Hum Immunol 64(4):440-452, 2003. PMID: 12651070
  • Espenschied J, Lamont J, Longmate J, Pendas S, Wang Z, Diamond DJ, and Ellenhorn JD. CTLA-4 blockade enhances the therapeutic effect of an attenuated poxvirus vaccine targeting p53 in an established murine tumor model. J Immunol 170(6):3401-3407, 2003. PMID: 12626601
  • Epel M, Ellenhorn JD, Diamond DJ, and Reiter Y.  A functional recombinant single-chain T cell receptor fragment capable of selectively targeting antigen-presenting cells.  Cancer Immunol Immunother 51(10):565-573, 2002. PMID: 12384808
  • La Rosa C, Wang Z, Brewer JC, Lacey SF, Villacres MC, Sharan R, Krishnan R, Crooks M, Markel S, Maas R, and Diamond DJ. Preclinical development of an adjuvant-free peptide vaccine with activity against CMV pp65 in HLA transgenic mice. Blood 100(10):3681-3689, 2002. PMID: 12393676
  • Lacey SF, Gallez-Hawkins G, Crooks M, Spielberger R, Forman SJ, Zaia JA and Diamond DJ. Characterization of cytotoxic function of CMV-pp65-specific CD8+ T-lymphocytes identified by HLA tetramers in recipients and donors of stem-cell transplants. Transplantation 74(5):722-732, 2002. PMID: 12352893
  • Gallez-Hawkins G, Lomeli NA, Li XL, Yao ZQ, La Rosa C, Diamond DJ, and Zaia JA. Kinase-deficient CMVpp65 triggers a CMVpp65-specific T-cell immune response in HLA-A*0201.Kb transgenic mice after DNA immunization. Scand J Immunol 55(6):592-598, 2002. PMID: 12028562
  • BenMohamed L, Krishnan R, Auge C, Primus JF, and Diamond DJ. Intranasal administration of a synthetic lipopeptide without adjuvant induces systemic immune responses. Immunology 106(1):113-121, 2002. PMID: 11972639
  • Villacres MC, Lacey SF, La Rosa C, Krishnan R, Auge C, Longmate J, Zaia JA, Leedom JM, and Diamond DJ. Human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy maintain activated CD8+ T cell subsets as a strong adaptive immune response to cytomegalovirus. J Infect Dis 184(3):256-267, 2001. PMID: 11443550
  • Zaia JA, Gallez-Hawkins G, Liu X, Yao ZQ , Lomeli N, Molinder K, La Rosa C, and Diamond DJ. Infrequent occurrence of natural mutations in the pp65 495-503 epitope sequence presented by the HLA A*0201 allele among human cytomegalovirus isolates. J Virol 75(5):2472-2474, 2001. PMID: 11160752
  • Yao ZQ, Gallez-Hawkins G, Lomeli NA, Li X,  Molinder KM, Diamond DJ, and Zaia JA. Site-directed mutation in a conserved kinase domain of human cytomegalovirus-pp65 with preservation of cytotoxic T lymphocyte targeting. Vaccine 19(13-14):1628-1635, 2001. PMID: 11166885
  • La Rosa C, Krishnan R, Markel S, Schneck JP, Houghten R, Pinilla C, and  Diamond DJ. Enhanced Immune activity of cytotoxic T-lymphocyte epitope analogues derived from positional scanning synthetic combinatorial libraries. Blood 97(6):1776-1786, 2001. PMID:11238120
  • Longmate J, York J, La Rosa C, Krishnan R, Zhang M, Senitzer D, and Diamond DJ. Population coverage by HLA class-I restricted cytotoxic T-lymphocyte epitopes. Immunogenetics 52 (3-4):165-173, 2001. PMID: 11220618
  • Zaia JA, Sissons JGP, Riddell S, Diamond DJ, Wills MR, Carmichael AJ, Weekes MP, Gandhi M, La Rosa C, Villacres M, Lacey S, Markel S, and Sun J. Status of cytomegalovirus prevention and treatment in 2000. Hematology Am Soc Hematol Educ Program pp.339-355, 2000. PMID: 11701550
  • BenMohamed L, Krishnan R, Longmate J, Auge C, Low L, Primus J, and Diamond DJ. Induction of CTL response by a minimal epitope vaccine in HLA A*0201/DR1 transgenic mice: dependence on HLA class II restricted T(H) response. Hum Immunol 61(8):764-779, 2000. PMID: 10980387
  • Liu X, Peralta EA, Ellenhorn JD, and Diamond DJ. Targeting of human p53-       overexpessing tumor cells by an HLA A*0201-restricted murine T-Cell receptor expressed in Jurkat T cells. Cancer Res 60(3):693-701, 2000. PMID: 10676655
  • Peralta EA, Liu X, McCarty TM, Wilson TG, Diamond DJ, and Ellenhorn JD. Immunotherapy of bladder cancer targeting p53. J Urol 162(5):1806-1811, 1999. PMID: 10524939
  • Schwarz RE, McCarty TM, Peralta EA, Diamond DJ, and Ellenhorn JDI. An orthotopic in vivo model of human pancreatic cancer. Surgery 126(3):562-567, 1999. PMID: 10486610
  • McCarty TM, Yu Z, Liu X, Diamond DJ, and Ellenhorn JD.  An HLA-restricted, p53 specific immune response from HLA transgenic p53 knockout mice. Ann Surg Oncol 5(1):93-99, 1998. PMID: 9524714
  • McCarty TM, Liu X, Sun JY, Peralta EA, Diamond DJ, and Ellenhorn JD. Targeting p53 for adoptive T-Cell immunotherapy. Cancer Res 58(12):2601-2605, 1998. PMID: 9635585
  • McCarty TM, Liu X, Schwarz RE, Diamond DJ, and Ellenhorn JD. Targeting  p53 for adoptive T cell immunotherapy. Owen H. Wangensteen Surgical Forum 48:783 785, 1997.
  • Diamond DJ, York J, Sun JY, Wright CL, and Forman SJ. Development of a candidate HLA A*0201 restricted peptide-based vaccine against human cytomegalovirus infection. Blood 90(5):1751-1767, 1997. PMID: 9292508
  • Yu Z, Liu X, McCarty TM, Diamond DJ, and Ellenhorn JDI. The use of transgenic mice to generate high affinity p53 specific cytolytic T cells. J Surg Res 69(2):337-343, 1997. PMID: 9224403
  • Krangel MS, Buchwalder A, York J, and Diamond DJ.  Lipid anchored and soluble forms of TCR molecules. In: Oksenberg JR (ed). The Human Antigen T Cell Receptor: Selected Protocols and Applications, pp 546-631. Georgetown, TX: R. G. Landes Company, 1997.
  • Liu X, Chesnokova V, Forman SJ and Diamond DJ. Methods for determining expression and oligoclonality of TCRs in GVHD lesions from allogeneic BMT recipients.  In: Oksenberg JR (ed). The Human Antigen T Cell Receptor: Selected Protocols and Applications, pp 432-459. Georgetown, TX: R. G. Landes Company, 1997.
  • Ellenhorn JDI, Yu Z, Diamond DJ. Generation of p53 specific and HLA restricted cytolytic T lymphocytes using recombinant vaccinia virus and HLA transgenic mice. Owen H. Wangensteen Surgical Forum 47:503 505, 1996.
  • Liu X, Chesnokova V, Forman SJ, and Diamond DJ. Molecular analysis of T-cell receptor repertoire in bone marrow transplant recipients: evidence for oligoclonal T-cell expansion in graft-versus-host disease lesions. Blood 87(7):3032-3044, 1996. PMID: 8639927
  • Diamond DJ, Chang KL, Jenkins KA, and Forman SJ. Immunohistochemical  analysis of T cell phenotypes in patients with graft-versus-host-disease following allogeneic bone marrow transplantation. Transplantation 59(10):1436-1444, 1995. PMID: 7770932
  • Buchwalder A, Krangel MS, Hao P, and Diamond DJ. Immunochemical and molecular analysis of antigen binding to lipid anchored and soluble forms of an MHC independent human alpha/beta T cell receptor. Mol Immunol 31(11):857-872, 1994. PMID: 8047075
  • Symer DE, Dintzis RZ, Diamond DJ, and Dintzis HM. Inhibition or activation of human T cell receptor transfectants is controlled by defined, soluble antigen arrays. J Exp Med 176(5):1421-1430, 1992. PMID: 1402685
  • Brown DA, Kondo KL, Wong SW, and Diamond DJ. Characterization of nuclear protein binding to the Interferon-gamma promoter in quiescent and activated human T cells. Eur J Immunol 22(9):2419-2428, 1992. PMID: 1516629
  • Diamond DJ, Szalay P, Symer D, Hao P, Shin HS, Dintzis RZ, Dintzis HM, Reinherz EL, and Siliciano RF. Major histocompatibility complex independent T cell receptor-antigen interaction: functional analysis using fluorescein derivatives. J Exp Med 174(1):229-241, 1991. PMID: 2056277
  • Brown DA, Nelson FB, Reinherz EL, and Diamond DJ. The human Interferon-gamma gene contains an inducible promoter that can be transactivated by tax I and II. Eur J Immunol 21(8):1879-1885, 1991. PMID: 1831129
  • Diamond DJ, Nelson FB, and Reinherz EL. Lineage specific expression of a T Cell receptor variable gene promoter controlled by upstream sequences. J Exp Med 169(4):1213 1231, 1989. PMID: 2522500
  • Diamond DJ, Clayton LK, Sayre PH, and Reinherz EL.  Exon intron organization and sequence comparison of human and murine T11 (CD2) genes. Proc Natl Acad Sci 85(5):1615 1619, 1988. PMID: 2894031
  • Clayton LK, Ramachandran H, Pravtcheva D, Chen YF, Diamond DJ, Ruddle FH, and Reinherz EL. The gene for T11 (CD2) maps to chromosome 1 in humans and to chromosome 3 in mice. J Immunol 140(10):3617-3621, 1988. PMID: 2896210
  • Hayday AC, Diamond DJ, Tanigawa G, Heilig JS, Folsom V, Saito H, and Tonegawa S. Unusual organization and diversity of T-cell receptor alpha-chain genes. Nature 316(6031):828-832, 1985. PMID: 2993907
  • Diamond DJ and Goodman HM. Regulation of growth hormone messenger RNA synthesis by dexamethasone and triiodothyronine: Transcriptional rate and mRNA stability changes in pituitary tumor cells. J Mol Biol 181(1):41-62, 1985. PMID: 3981636
  • Fukata J, Diamond DJ, and Martin JB. Effects of rat growth hormone (rGH)-releasing factor and somatostatin on the release and synthesis of rGH in dispersed pituitary cells.  Endocrinology 117(2):457-467, 1985. PMID: 2862007
  • Moore DD, Walker MD, Diamond DJ, Conkling MA, and Goodman HM. Structure, expression, and evolution of growth hormone genes. Recent Prog Hor Res 38:197-225, 1982. PMID: 6289392
  • Goodman HM, Berg P, Clark S, Cordell B, Diamond DJ, Nguyen-Huu C, Kan YW, and Lebo RV. Structure, evolution and expression of mammalian insulin genes. In: Schmitt FO, Bird SJ, and Bloom FE (eds.), Molecular Genetic Neuroscience, pp.103-115. New York: Raven Press, 1982.
  • Cordell B, Diamond D, Smith S, Punter J, Schone HH, and Goodman, HM. Disproportionate expression of the two nonallelic rat insulin genes of a pancreatic tumor is due to translational control. Cell 31(3):531-542, 1982. PMID: 6297771
  • Lehrach H, Diamond D, Wozney JM, and Boedtker H. RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination. Biochemistry 16(21):4743-4751, 1977. PMID: 911786
  • Diamond DJ. Studies at the scute locus of Drosophila melanogaster. Seccan News Magazine 4:1-4, 1973.
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