Flavia Chiuppessi

Flavia Chiuppesi, Ph.D.

  • Staff Scientist, Department of Experimental Therapeutics

Flavia Chiuppesi, Ph.D.

Research Focus :
  • Identification and analysis of HCMV-specific neutralizing antibodies
  • In vivo investigation of the humoral response to HCMV vaccine candidates
  • Optimization of novel HCMV vaccine candidates
  • Analysis of the neutralizing antibody response to HCMV in transplant recipients
  • 2012 - Present, Postdoctoral Fellow, Department of Experimental Therapeutics, Beckman Research Institute of City of Hope, Duarte CA
  • 2011-2012, Postdoctoral Fellow, Retrovirus Centre of the University of Pisa, Italy
  • 2011 - University of Pisa, Italy, Ph.D., Virology
  • 2007 - University of Pisa, Italy, M.S. Molecular Science & Technology
  • 2005 - University of Pisa, Italy, B.S. Molecular Biology
  • Wussow F, Chiuppesi F, Zhuo M, Martinez J, Nguyen J, Barry PA, Diamond DJ. 2017. Exploiting 2A peptides to elicit potent neutralizing antibodies by a multi-subunit herpesvirus glycoprotein complex. J Virological Methods, In Press, doi.org/10.1016/j.jviromet.2017.10.006.
  • Chiuppesi F, Wussow F, Scharf L, Contreras H, Gao H, Zhuo M, Nguyen J, Barry PA, Bjorkman PJ, Diamond DJ. 2017. Comparison of homologous and heterologous prime-boost vaccine approaches to induce neutralizing antibodies by the human cytomegalovirus pentamer complex in mice. PLoS 12(8):e0183377. doi: 10.1371/journal.pone.0183377.
  • Nelson CS, Vera Cruz D, Tran D, Bialas KM, Stamper L, Wu H, Gilbert M, Blair R, Alvarez X, Itell H, Chen M, Deshpande A, Chiuppesi F, Wussow F, Diamond DJ, Vandergrift NA, Walter M, Cohen-Wolkowiez M, Barry PA, Koelle K, Kaur A, Permar SR. 2017. Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys. JCI Insight 2(13):e94002. doi:10.1172/jci.insight.94002.
  • Fan Q, Nelson CS, Bialas KM, Chiuppesi F, Amos J, Gurley TC, Marshall DJ, Eudailey J, Heimsath H, Himes J, Deshpande A, Water MR, Wussow F, Diamond DJ, Barry PA, Moody MA, Kaur A, Permar SR. 2017. Plasmablast response to primary rhesus cytomegalovirus infection in a monkey model of congenital CMV transmission. Clin Vaccine Immunol, 24(5). pii: e00510-16, doi:10.1128/CVI.00510-16.
  • Chiuppesi F, Kaltcheva T, Zhuo M, Barry PA, Diamond DJ, Wussow F. 2017. Identification of a continuous neutralizing epitope within UL128 of human cytomegalovirus. J Virol 91(6):e01857-16, doi: 10.1128/JVI.01857-16.
  • La Rosa C, Longmate J, Martinez J, Zhou Q, Kaltcheva TI, Tsai W, Drake J, Carroll M, Wussow F, Chiuppesi F, Hardwick N, Dadwal S, Aldoss I, Nakamura R, Zaia JA, Diamond DJ.  2017. MVA vaccine encoding CMV antigens safely induces durable expansion of CMV-specific T cells in healthy adults. Blood 129:114-125.
  • Donalisio M, Quaranta P, Chiuppesi F, Pistello M, Cagno V, Cavalli R, Volante M, Bugatti A, Rusnati M, Ranucci E, Ferruti P, Lembo D. 2016. The AGMA1 poly(amidoamine) inhibits the infectivity of herpes simplex virus in cell lines, in human cervicovaginal histocultures, and in vaginally infected mice. Biomaterials 85:40-53.
  • Bialas KM, Tanaka T, Tran D, Varner V, Cisneros De La Rosa E, Chiuppesi F, Wussow F, Kattenhorn L, Macri S, Kunz EL, Estroff JA, Kirchherr J, Yue Y, Fan Q, Lauck M, O'Connor DH, Hall AH, Xavier A, Diamond DJ, Barry PA, Kaur A, Permar SR. 2015. Maternal CD4+ T cells protect against severe congenital cytomegalovirus disease in a novel nonhuman primate model of placental cytomegalovirus transmission. Proc Natl Acad Sci U S A 112:13645-13650.
  • Chiuppesi F, Wussow F, Johnson E, Bian C, Zhuo M, Rajakumar A, Barry PA, Britt WJ, Chakraborty R, Diamond DJ. 2015. Vaccine-derived neutralizing antibodies to the human cytomegalovirus gH/gL pentamer potently block primary cytotrophoblast infection. J Virol 89:11884-11898.
  • Wussow F, Chiuppesi F, Martinez J, Campo J, Johnson E, Flechsig C, Newell M, Tran E, Ortiz J, La Rosa C, Herrmann A, Longmate J, Chakraborty R, Barry PA, Diamond DJ. 2014. Human cytomegalovirus vaccine based on the envelope gH/gL pentamer complex. PLoS Pathog 10:e1004524.
  • Agostini S, Lionetti V, Matteucci M, Chiuppesi F, Giacca M, Pistello M, Recchia FA. 2013. A new dual-promoter system for cardiomyocyte-specific conditional induction of apoptosis. Biomed Res Int 2013:845816.
  • Vannucci L, Lai M, Chiuppesi F, Ceccherini-Nelli L, Pistello M. 2013. Viral vectors: a look back and ahead on gene transfer technology. New Microbiol 36:1-22.
  • Celestino M, Calistri A, Del Vecchio C, Salata C, Chiuppesi F, Pistello M, Borsetti A, Palu G, Parolin C. 2012. Feline tetherin is characterized by a short N-terminal region and is counteracted by the feline immunodeficiency virus envelope glycoprotein. J Virol 86:6688-6700.
  • Chiuppesi F, Vannucci L, De Luca A, Lai M, Matteoli B, Freer G, Manservigi R, Ceccherini-Nelli L, Maggi F, Bendinelli M, Pistello M. 2012. A lentiviral vector-based, herpes simplex virus 1 (HSV-1) glycoprotein B vaccine affords cross-protection against HSV-1 and HSV-2 genital infections. J Virol 86:6563-6574.
  • Campan M, Lionetti V, Aquaro GD, Forini F, Matteucci M, Vannucci L, Chiuppesi F, Di Cristofano C, Faggioni M, Maioli M, Barile L, Messina E, Lombardi M, Pucci A, Pistello M, Recchia FA. 2011. Ferritin as a reporter gene for in vivo tracking of stem cells by 1.5-T cardiac MRI in a rat model of myocardial infarction. Am J Physiol Heart Circ Physiol 300:H2238-2250.
  • Vannucci L, Chiuppesi F, di Martino F, Caligo MA, Bevilacqua G, Pistello M. 2010. Feline immunodeficiency virus vector as a tool for preventative strategies against human breast cancer. Vet Immunol Immunopathol 134:132-137.
  • Pistello M, Vannucci L, Ravani A, Bonci F, Chiuppesi F, del Santo B, Freer G, Bendinelli M. 2007. Streamlined design of a self-inactivating feline immunodeficiency virus vector for transducing ex vivo dendritic cells and T lymphocytes. Genet Vaccines Ther 5:8.
  • 2015, Best Poster in the Postdoctoral Fellow Category, City of Hope Annual Poster Session for 2015, “Collaboration: Experimental Approaches to Medical Challenges”.
  • 2014, Best Poster in the Postdoctoral Fellow Category, City of Hope Annual Poster Session for 2014, “Collaboration: Scientific Exploration and Therapeutic Advances”.
  • 2012, Full Scholarship for the “Institute Pasteur Vaccinology Course 2012” Pasteur Institute, Paris, France (3/1-3/29)
  • 2010, Full Scholarship for the 3rd Hong Kong University (HKU) - Pasteur Immunology course HKU-Pasteur Research Centre, Hong Kong, China (11/1-11/12)
  • 2010, Full Scholarship for the ZIBI-International Summer School on Pathogen-Host-Interplay “Interdisciplinary Center for Infection Biology and Immunity" of the Humboldt-University (ZIBI), Berlin, Germany (7/11-7/24)
  • 2009, European qualification in biochemical technician expert in industry and Territorial servicesn, University of Pisa and Regione Toscana
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