Gang Xiao, Ph.D.
- Assistant Research Professor, Department of Systems Biology
Gang Xiao, Ph.D.
Gang Xiao, Ph.D., received his doctoral degree at Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences. His previous work was supervised by Dr. Xiaolong Liu and focused on regulation of checkpoint molecule PD-1 during T cell anti-tumor immune responses and thymocyte development.
During his postdoctoral training with Markus Müschen, M.D., Ph.D., at the University of California, San Francisco, Dr. Xiao’s research was mainly focused on the role of the inhibitory phosphatase PP2A in the regulation of glucose metabolism, redox homeostasis and oncogenic signaling in normal B cell development, and B cell leukemia and lymphoma.
Dr. Xiao joined the Department of Systems Biology at Beckman Research Institute of City of Hope in 2017 and is an assistant research professor in the Division of Epigenetic and Transcriptional Engineering.
- 2012, Ph.D., Cell Biology, Institute of Biochemistry and Cell Biology, SIBS, Chinese Academy of Sciences
- 2006, B.Eng., Bioengineering, East China University of Science and Technology, Shanghai
- 2017-present, Department of Systems Biology, Beckman Research Institute of City of Hope, Duarte, CA
Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sanchez-Garcia S, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG and Müschen M. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature 542: 479–483 (2017)
Geng H, Hurtz C, Lenz KB, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen WY, Huan J, LaTocha D, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, Park E, Huang C, Nahar R, Kweon SM, Shojaee S, Chan LN, Yu J, Kornblau SM, Bijl JJ, Ye BH, Ansel KM, Paietta E, Melnick A, Hunger SP, Kurre P, Tyner JW, Loh ML, Roeder RG, Druker BJ, Burger JA, Milne TA, Chang BH and Müschen M. Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. Cancer Cell 27: 409-425 (2015)
Xiao G, Deng A, Liu H, Ge G and Liu X. Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1. Proc Natl Acad Sci USA 109: 15419-15424 (2012)
Wang X, Xiao G, Zhang Y, Wen X, Gao X, Okada S and Liu X. Regulation of Tcrb recombination ordering by c-Fos-dependent RAG deposition. Nature Immunology 9: 794-801 (2008)