The research of Jeannine McCune, Pharm.D., focuses on the clinical pharmacology of anticancer agents and immunosuppressants used to either treat or prevent cancer. Specifically, she has quantified the exposure of anti-cancer agents and immunosuppressants in hematopoietic cell transplant recipients used to treat malignant and nonmalignant conditions. She is currently developing mathematical models to identify anticancer agent plasma exposure effective at treating cancer and modeling drug doses and dosing frequencies to optimize efficacy in pediatric cancer patients. Her work also evaluates constitutional pharmacogenomics and metabolomics relevant to drug exposure and drug response.
She has received several major National Institutes of Health grants for personalized medicine with children and adults with cancer, and has over 130 publications in her areas of interest. She has also served as a charter member of the NIH Developmental Therapeutics Study Section (September 2009-June 2013) and is a member of Children’s Oncology Group trials.