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Jianjun Chen, Ph.D.

  • Professor and Vice Chair, Department of Systems Biology

Jianjun Chen, Ph.D.

Before joining Beckman Research Institute of City of Hope as a Full Professor and Associate Chair of the Department of Systems Biology in October 2017, Jianjun Chen, Ph.D., had been serving as an Associate Professor of Cancer Biology at the University of Cincinnati College of Medicine for a few years after moving from University of Chicago.
 
Dr. Jianjun Chen received his Ph.D. degree from Shanghai Institute of Biochemistry, Chinese Academy of Sciences, Shanghai, China, and then conducted postdoc training with Dr. Janet D. Rowley at University of Chicago. He launched his independent laboratory in 2009 in the Department of Medicine at University of Chicago.
 
Dr. Chen is a Scholar of the Leukemia and Lymphoma Society (LLS) (2017) and Researcher of the Year, The Pamela B. Katten Memorial Leukemia Research Foundation Award (2014). Dr. Jianjun Chen is a permanent Member of the NIH Developmental Therapeutics (DT) study section and his research program is currently supported by four R01 grants from the National Cancer Institute.
 
 
  • 2017 - present, Professor and Vice Chair, Department of Systems Biology, Beckman Research Institute of City of Hope, Duarte, CA
  • 2005 - 2008, Research Associate (Assistant Professor), Department of Medicine, University of Chicago, Chicago, IL
  • 2004 - 2005, Research Associate (Instructor), Department of Medicine, University of Chicago, Chicago, IL
  • 2001 - 2004, Research Associate, Department of Medicine, University of Chicago, Chicago, IL

Degrees

  • 1999, Ph.D., Biochemistry and Molecular Biology. Shanghai Institute of Biochemistry, Chinese Academy of Sciences, Shanghai, China
  • 1994, B.S., Genetics. Sichuan University, Chengdu, China

Fellowship

  • 1999-2001, Department of Medicine, University of Chicago
The Chen laboratory is interested in discovering novel genetic/epigenetic regulations and the associated molecular mechanisms of both protein-coding genes and non-coding RNAs (e.g., microRNAs) in normal developmental processes (e.g., hematopoiesis) and tumorigenesis (e.g., leukemogenesis). In recent years, Dr. Chen and colleagues have been focusing on both basic and translational research associated with RNA/DNA epigenetics, especially RNA methylation/demethylation related to the N6 methyladenosine (m6A) machinery and DNA demethylation related to the TET1/2/3 family, and have developed several small-molecule compound inhibitors to selectively target cancer-related RNA/DNA epigenetic modifiers that hold therapeutic potential. The ultimate goal of the lab is to translate the laboratory discoveries into the development of effective novel therapeutic strategies to treat cancers (especially acute leukemia) in the clinic.
  • Chen J, Xu H, Gao C, Sun M and Chen C. Cloning, Sequencing and Structure Analysis of the VL and VH Genes from Anti-hTNF-a Hybridoma Cell Line. Journal of Cellular and Molecular Immunology. 1997, 13(3):8-13 (Chinese).
  • Pan L, Chen J and Chen C. Cloning, Sequencing and Sequence Analysis of Goat beta-Lactoglobulin Gene 5' Flanking Region. Chinese Journal of Biotechnology. 1997, 13(2): 132-137 (Chinese).
  • Han L, Sun M, Chen J, Liang W, Chen C and Shu C. Construction and Analysis of Interactive Models of Metal-bound Tetrapeptide and Their Two Monoclonal Antibody Variable Regions. Journal of Cellular and Molecular Immunology. 1997, 13(3): 23-27 (Chinese).
  • Chen J, Sun M, Lu F, Chen C and Wang D. Construction and Application of a Prokaryotic High Level Expression Vector Containing PR Promoter. Prog. Biochem. Biophys. 1999, 26(5):495-499 (Chinese).
  • Chen J, Sun M, Lu F, Wang D and Chen C. Construction and Expression of hTNF-a/hTGF3 Fused Gene. Acta Biochmica et Biophysica Sinica. 1999, 31(5): 513-518 (Chinese).
  • Chen J, Sun M, Fang J, Liu H, Wang D and Chen C. Computer Modeling and Experimental Research of Interactions between Two Anti-hTNF-a Monoclonal Antibodies Variable Regions and hTNF-a. Chinese Journal of Biotechnology. 2000, 16(1): 36-41 (Chinese).
  • Chen J, Sun M, Wang D and Chen C. Model Research of Interactions between hTNF-a and Its Two Receptors. High Technology Letters. 2000, 2: 6-12 (Chinese).
  • Liu H, Lu F, Chen J, Ren H and Chen C. Construction of novel tumor necrosis factor-alpha mutants with reduced toxicity and higher cytotoxicity on human tumor cells. Science in China. 2003, 46(1): 1-9 (Chinese).
  • Chen J, Rowley JD and Wang SM. Generation of longer cDNA fragments from serial analysis of gene expression tags for gene identification. Proc. Natl. Acad. Sci. USA. 2000, 97(1): 349-353.
  • Wang SM, Fears SC, Zhang L, Chen J and Rowley JD. Screening poly dA/dT(-) cDNAs for gene identification. Proc. Natl. Acad. Sci. USA. 2000, 97(8): 4162-4166.
  • Lee S, Zhou G, Clark T, Chen J, Rowley JD and Wang SM. The pattern of gene expression in human CD15+ myeloid progenitor cells. Proc. Natl. Acad. Sci. USA. 2001, 98(6):3340-3345.
  • Lee S, Chen J (the first two authors contributed equally), Zhou G and Wang SM. Generation of high quality and quantity of tag/ditag for SAGE analysis. BioTechniques. 2001, 31(2):348-354.
  • Chen J, Rowley DA, Clark T, Lee S, Zhou G, Beck C, Rowley JD and Wang SM. The pattern of gene expression in mouse Gr-1+ myeloid progenitor cells. Genomics. 2001, 77(3): 149-162.
  • Zhou G, Chen J, Lee S, Clark T, Rowley JD and Wang SM. The pattern of gene expression in human CD34+ stem/progenitor cells. Proc Natl Acad Sci USA. 2001, 98(24): 13966-13971.
  • Chen J, Lee S, Zhou G and Wang SM. High-throughput GLGI procedure for converting a large number of serial analysis of gene expression tag sequences into 3 complementary DNAs. Genes, Chromosomes & Cancer. 2002, 33(3): 252-261.
  • Lee S, Clark T, Chen J (the first three authors contributed equally), Zhou G, Rowley JD and Wang SM. Accurate identification of genes from SAGE tag sequences. Genomics. 2002, 79(4):598-602.
  • Zhang YM, Strissel P, Strick R, Chen J, Nucifora G, LeBeau MM, Larson RA and Rowley JD. Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia. Proc Natl Acad Sci USA. 2002. 99(5): 3070-3075.
  • Nam DK, Lee S, Zhou G, Cao X, Wang C, Clark T, Chen J, Rowley JD and Wang SM. Oligo dT primer generates a high frequency of truncated cDNAs through internal poly A priming during reverse transcription. Proc Natl Acad Sci USA. 2002. 99(9): 6152-6156.
  • Muschen M, Lee S, Zhou G, Feldhahn N, Barath V S, Chen J, Moers C, Kronke M, Rowley JD and Wang SM. Molecular portraits of B cell lineage commitment. Proc Natl Acad Sci USA. 2002. 99 (15): 10014-10019.
  • Chen J, Sun M, Lee S, Zhou G, Rowley JD and Wang SM. Identifying novel transcripts and novel genes in the human genome by using novel SAGE tags. Proc Natl Acad Sci USA. 2002. 99(19): 12257-12262.
  • Zou GM, Wu W, Chen J and Rowley JD. Duplexes of 21-nucleotide RNAs mediate RNA interference in differentiated mouse ES cells. Biol Cell. 2003. 95(6): 365-371.
  • Sun M, Zhou G, Lee S, Chen J, Shi RZ and Wang SM. SAGE is far more sensitive than EST for detecting low-abundance transcripts. BMC Genomics. 2004. 5(1): 1.
  • Zhang Y, Emmanuel N, Kamboj G, Chen J, Shurafa M, Van Dyke DL, Wiktor A and Rowley JD. PRDX4, a member of the peroxiredoxin family, is fused to AML1 (RUNX1) in an acute myeloid leukemia patient with a t(X;21) (p22;q22).Genes, Chromosomes & Cancer. 2004. 40(4): 365-370.
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