Joe Gold, Manufacturing Director, Center for Biomedicine and Genetics, City of Hope

Joseph Gold, Ph.D.

  • Director of Manufacturing, Center for Biomedicine & Genetics

Joseph Gold, Ph.D.

Research Focus :
  • Scientific innovations in cell, molecular and developmental biology, regenerative medicine and assay development
  • 2016 - present, Director, Manufacturing, Center for Biomedicine & Genetics, Beckman Research Institute of City of Hope, Duarte, CA
  • 2012 - 2016, Assistant Director, Translational Research, Stanford University Cardiovascular Institute
  • 2011 - 2012, Senior Director of Neurobiology and Stem Cell Therapies, Geron Corporation
  • 2007 - 2011, Senior Director of Stem Cell Biology and Research Operations, Geron Corporation
  • 2005 - 2006, Director of Stem Cell Biology and Research Operations, Geron Corporation
  • 2003 - 2004, Associate Director, Stem Cell Biology, Geron Corporation
  • 2003 - 2004, Project Leader, Cardiovascular Disease Project, Geron Corporation
  • 2001 - 2002, Group Leader, Genetic Engineering, Geron Corporation
  • 1998 - 2002, Team Leader, Embryonic Stem Cell Program, Geron Corporation
  • Center for Biomedicine & Genetics

Degrees

  • 1991, Ph.D., Cell and Developmental Biology, Harvard University, Cambridge, MA
  • 1983, B.A., University of Pennsylvania, Philadelphia, PA, 1983

Fellowship

  • 10/90 - 12/95, Postdoctoral Fellow, Laboratory of Dr. Roger Pedersen, Laboratory of Radiobiology and Environmental Health, University of California San Francisco, San Francisco, CA
  • Riegler J, Ebert A, Qin X, Shen Q, Wang M, Ameen M, Kodo K, Ong SG, Lee WH, Lee G, Neofytou E, Gold JD, Connolly AJ, Wu JC. Comparison of Magnetic Resonance Imaging and Serum Biomarkers for Detection of Human Pluripotent Stem Cell-Derived Teratomas. Stem Cell Reports. 2016 Feb 9;6(2):176-87
  • Riegler J, Tiburcy M, Ebert A, Tzatzalos E, Raaz U, Abilez OJ, Shen Q, Kooreman NG, Neofytou E, Chen VC, Wang, M, Tsao PS, Connolly AJ, Couture LA, Gold JD, Zimmermann WH, Wu JC. Human engineered heart muscles engraft and survive long term in a rodent myocardial infarction model.  Circ Res. 2015 Sep 25;117(8):720-30. 
  • Wu H, Lee J, Vincent LG,  Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JC. Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised b-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy. Cell Stem Cell (2015), http://dx.doi.org/10.1016/j.stem.2015.04.020
  • French A., Bravery C, Smith J, Chandra A, Archibald P, Gold JD, Artzi N, Kim HW, Barker RW, Meissner A, Wu JC, Knowles JC, Williams D, García-Cardeña G, Sipp D, Oh S, Loring JF, Rao MS, Reeve B, Wall I, Carr AJ, Bure K, Stacey G, Karp JM, Snyder EY, Brindley DA. Enabling Consistency in Pluripotent Stem Cell-Derived Products for Research and Development and Clinical Applications Through Material Standards. Stem Cells Transl Med  2015 Mar;4(3):217-23.
  • Gu M, M. Mordwinkin NM, Kooreman NG, Lee J, Wu H, Hu S, Churko JM, Diecke S, Burridge P, He C, Barron FE, Ong S-G, Gold JD, Wu JC. Pravastatin reverses obesity-induced dysfunction of induced pluripotent stem cell-derived endothelial cells via a nitric oxide-dependent mechanism.  European Heart Journal 2015 Apr 1;36(13):806-16
  • Ong S-G, Lee WH, Huang M, Dey D, Kodo K, Sanchez-Freire V, Gold JD, Wu JC. Cross talk of combined gene and cell therapy in ischemic heart disease: role of exosomal microRNA transfer.  Circulation 2014 130: S60-S69
  • Riegler J, Gillich A, Shen Q, Gold JD, Wu JC. Cardiac Tissue Slice Transplantation as a Model to Assess Tissue-Engineered Graft Thickness, Survival, and Function.  Circulation 2014 130: S77-S86. 
  • Ebert AD, Kodo K, Liang  P, Wu H, Huber BC, Riegler J, Churko J, Lee J, de Almeida P, Lan F, Diecke S, Burridge PW, Gold JD, Mochly-Rosen D, Wu JC. Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system. Sci. Trans. Med 24 September 2014: Vol. 6, Issue 255, p. 255ra130.   
  • Wang Y, Liang P, Lan F, Wu H, Lisowski L, Gu M, Hu S, Kay MA, Urnov FD, Shinnawi R, Gold JD, Gepstein L, Wu JC. Genome editing of isogenic human induced pluripotent stem cells recapitulates long QT phenotype for drug testing. J Am Coll Cardiol. 2014 Aug 5;64(5):451-9.
  • Burridge PW, Matsa E, Shukla P, Lin ZC, Churko JM, EbertAD, Lan F, Diecke S, Huber B, Mordwinkin NM, Abilez OA, Cui B, Gold JD, Wu JC. Chemically defined generation of human cardiomyocytes. Nature Methods 2014, Published online 15 June 
  • Shiba Y, Filice D, Fernandes S, Minami E, Dupras SK, Biber BV, Trinh P, Hirota Y, Gold JD, Viswanathan M, Laflamme MA. Electrical Integration of Human Embryonic Stem Cell-Derived Cardiomyocytes in a Guinea Pig Chronic Infarct Model. J Cardiovasc Pharmacol Ther. 2014 19(4):368-381
  • Huber BC, Ransohoff JD, Ransohoff KJ, Riegler J, Ebert A, Kodo K, Gong Y, Sanchez-Freire V, Dey D, Kooreman NG, Diecke S, Zhang WY, Odegaard J, Hu S, Gold JD, Robbins RC, Wu JC. Costimulation-adhesion blockade is superior to cyclosporine A and prednisone immunosuppressive therapy for preventing rejection of differentiated human embryonic stem cells following transplantation.  Stem Cells. 2013 Nov;31(11):2354-63
  • Gold JD, Wu JC. Returns of the living dead: therapeutic action of irradiated and mitotically inactivated embryonic stem cells. Circ Res. 2012 Oct 26;111(10):1250-2
  • Shiba Y, Fernandes S, Minami E, Dupras S, Van Biber B, Trinh P, Hirota Y, Gold JD, Viswanathan M, Laflamme MA. Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts. Nature 2012 489,322–325
  • Burridge, PW, Gold, JD, Keller, G, Wu JC. Production of De Novo Cardiomyocytes: Human Pluripotent Stem Cell Differentiation and Direct Reprogramming. Cell Stem Cell 2012,10(1): 16-28, 6 January
 
  • Phi Beta Kappa Society, University of Pennsylvania
  • Summa Cum Laude, University of Pennsylvania
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