Experimental Therapeutics - Joshua Nyagol

Joshua Nyagol, Ph.D.

  • Postdoctoral Fellow, Department of Experimental Therapeutics

Joshua Nyagol, Ph.D.

Research Focus :
  • Vaccine design for oncogenic viruses
  • Immunotherapy for oncogenic viral-associated cancers
  • Molecular diagnostics of pathogen-associated malignancies.
  • 2016-present, Postdoctoral Fellow, Department of Experimental Therapeutics, Beckman Research Institute at City of Hope, Duarte, CA
  • 2014-present, Senior Lecturer, Unit of Immunology, Department of Human Pathology, University of Nairobi, Kenya
  • 2014-2016, Consultant / Laboratory Scientist, The Nairobi Hospital, Kenya
  • 2009-2014, Lecturer, Department of Human Pathology, University of Nairobi, Kenya
  • 2008, Honorary Lecturer, Department of Pathology, Aga Khan University Hospital, Nairobi, Kenya
  • 2001-2003, Research Fellow, Pathology Department, The Nairobi Hospital, Kenya
  • 2007, University of Siena, Italy, Ph.D., Medical Biotechnology (Quantitative & Molecular Diagnostic Pathology)
  • 2001, Egerton University, Kenya, B.S., Biochemistry & Chemistry
  • Emily A. Rogena, Keneth O. Simbiri, G. De Falco, L. Leoncini, Leona Ayers and J. Nyagol. A review of the pattern of AIDS defining, HIV associated neoplasm and premalignant lesions diagnosed from 2000-2011 at Kenyatta National Hospital, Kenya. Infectious Agents and Cancer. 2015, 10(28): doi: 10.1186/s13027-015-0021-1.
  • Rutto EK, Nyagol J, Oyugi J, Ndege S, Onyango N, Obala A, Simiyu CJ, Boor G, Cheriro WC, Otsyula B, Estambale B.  Effects of HIV-1 infection on malaria parasitemia in milo sub-location, western Kenya. BMC Res Notes. 2015 Jul 15; 8:303. doi: 10.1186/s13104-015-1270-1.
  • Mwololo A, Nyagol J, Rogena E, Ochuk W, Kimani M, Onyango N, Pacenti L, Santopietro R, Leoncini L, Mwanda W. Correlation of EGFR, pEGFR and p16INK4 expressions and high risk HPV infection in HIV/AIDS-related squamous cell carcinoma of conjunctiva. Infect Agent Cancer. 2014, 9(1): 7. DOI: 10.1186/1750-9378-9-7
  • J. Nyagol, V. Kisato, W. Ochuk, M. Wakio. Assessment of hormonal receptors and Her-2/neu status in breast cancer using cell block: a case study. J. Afr. Cancer (2013) 5: 180-184.
  • D Lenze, L Leoncini, M Hummel, S Volinia, CG Liu, T Amato, G De Falco, J Githanga, H Horn, J Nyagol, G Ott, J Palatini, M Pfreundschuh, E Rogena, A Rosenwald, R Siebert, CM Croce and H Stein. The different epidemiologic subtypes of Burkitt lymphoma share a homogenous micro RNA profile distinct from diffuse large B-cell lymphoma. Leukemia (2011), 1-8.  
  • Leucci E, Onnis A, Cocco M, Costanzo V, Cerino G, Mannuci S, Castisani R, Nyagol J, Mwanda W, Iriso R, Schurfeld K, Bellan C, Leoncini L. B cell differentiation in EBV-positive Burkitt Lymphoma is impaired at post-transvriptional level by miRNA altered expression. Int J. Cancer. 2010; 126 (6): 1316-26.  
  • Leucci E, Cocco M, Onnis A, van Cleef P, Bellan C, van Rijk A, De Falco G, Nyagol J, Byakika B, Lazzi S, Tosi P, van Krieken J, Leoncini L. MYC-negative classical Burkitt’s Lymphoma cases: an alternative pathogenetic mechanism involving miRNA deregulation. [J Pathol. 2008 ; 216 (4) :440-50.
  • Nyagol J,  De Falco G, Shahin S, Bellan C, Spina D, Lazzi S, Leoncini L.  HIV-1 Tat mimetic of VEGF correlates with increased micro vessel density in diffuse large B-cell and Burkitt’s lymphomas. J.Hematopath, 2008. DOI 10.1007/s12308-008-0002-z.
  • De Falco G, Leucci E, Lenze D, Piccaluga PP, Claudio PP, Onnis A, Cerino G, Nyagol J, Mwanda W, Bellan C, Hummel M, Pileri S, Tosi P, Stein H, Giordano A, Leoncini L. Gene expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt's lymphoma cell lines and primary tumors. Blood.  2007; 110(4):1301-7.
  • Nyagol J, Leucci E, DeFalco G.  et al. The Effects of HIV-1 Tat Protein on Cell Cycle during Cervical Carcinogenesis. Cancer Biol Ther. 2006, 5 (6):684-90.
  • Nyagol J, Nyong’o A, Byakika B, et al. Routine assessment of hormonal receptor and Her-2/neu status underscores the need for more therapeutic targets in Kenyan women with breast cancer. J. of AQCH 2006, 28(2):97-103.
  • Bellan C, Lazzi S, Hummel M, Palummo N, de Santi M, Amato T, Nyagol J, Sabattini E, Lazure T, Pileri SA, Raphael M, Stein H, Tosi P, Leoncini L. Immunoglobulin gene analysis reveals two distinct cells of origin for EBV-positive and EBV-negative Burkitt lymphomas. Blood. 2005; 106(3):1031-6.
  • 2003, Ph.D. Fellowship, Institute of Anatomic Pathology and Human Oncology, University of Siena, Italy
  • 2001, Roche Oncology Fellowship, SAIMR/Witwatersrand University, RSA
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