Teodora Kattcheva, Ph.D.

Teodora Kaltcheva, Ph.D.

  • Staff Scientist, Department of Experimental Therapeutics

Teodora Kaltcheva, Ph.D.

Research Focus :
  • Synthesis, purification and characterization of peptides and peptide libraries for Vaccine
  • Development and Tumor Immunology projects
  • Tetramer preparation for T-cell staining
  • Analysis of metabolites in mice sera and tumor cells
  • Fluorescent probes for imaging pancreatic cancer tumors
  • Fluorescent probes for imaging of neutrophils
  • Development and synthesis of peptide based vaccine
  • 2009-2015, Postdoctoral Fellow, Department of Experimental Therapeutics, Beckman Research Institute, City of Hope, Duarte, CA
  • 2012-2015, Biochemistry Instructor, Department of Humanities and Sciences, University of California (UCLA), Los Angeles, CA
  • 2007-2009, Research Assistant, Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT
  • 2003-2009, Graduate Student, Department of Chemistry, University of Southern California, Los Angeles, CA
  • 2004-2008, Research Advisor to undergraduate students, Department of Chemistry, University of Southern California, Los Angeles, CA
  • 2003-2007, Teaching Assistant, Department of Chemistry, University of Southern California, Los Angeles, CA
  • 2002-2003, Research Assistant, Stockton University, Pomona, NJ
  • 2009, University of Southern California, Los Angeles, CA, Ph.D., Chemistry
  • 2003, Stockton University, Pomona, NJ, B.Sc., Chemistry
  • Stephanie M. Stanford, Rekha G. Panchal, Logan M. Walker, Matthew D. Falk, Sayantan Mitra, Sagar Damle, David Ruble, Teodora Kaltcheva, Sheng Zhang, Zhong-Yin Zhang, Sina Bavari, Amy M. Barrios, and Nunzio Bottini, High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active CD45 inhibitors, PNAS, 2012, 109 (35), 13972-13977
  • Simon F. Lacey, Corinna La Rosa, Teodora Kaltcheva, Tumul Srivastava, Aprille Seidel, Wendi Zhou, Ravindra Rawal, Katharine Hagen, Aparna Krishnan, Jeff Longmate, Helen A. Andersson, Lisa St John, Ravi Bhatia§, Vinod Pullarkat, Stephen J. Forman, Laurence J.N. Cooper, JeffreyMolldrem, and Don J. Diamond, Characterization of immunologic properties of a second HLA-A2 epitope from a granule protease in CML patients and HLA-A2 transgenic mice, Blood, 2011, 118: 2159-2169
  • Edwin R. Manuel, Celine A. Blache, Rebecca Paquette, Teodora I Kaltcheva, Hidenobu Ishizaki, Joshua D. I. Ellenhorn, Michael Hensel, Leonid Metelitsa and Don J. Diamond, Enhancement of cancer vaccine therapy by systemic delivery of a tumortargeting Salmonella-based STAT3 shRNA suppresses the growth of established melanoma tumors, Cancer Research, 2011;71:4183-4191
  • Corinna La Rosa, Jeff Longmate, Simon F. Lacey, Teodora Kaltcheva, Rahul Sharan, Denise Marsano, Peter Kwon, Jennifer Drake, Brenda Williams, Sharon Denison, Suenell Broyer, Larry Couture, Ryotaro Nakamura, Morris I. Kelsey, Arthur M. Krieg, Don J. Diamond, and John A. Zaia, Clinical Evaluation of Safety and Immunogenicity of PADRE-Cytomegalovirus (CMV) and Tetanus-CMV Fusion Peptide Vaccines With or Without PF03512676 Adjuvant, Journal of Infectious Diseases 2012, 205 (8): 1294-1304
  • Céline A. Blache, Edwin R. Manuel, Teodora I. Kaltcheva, Andrea N. Wong, Joshua D.I. Ellenhorn, and Don J. Diamond, Systemic delivery of Salmonella typhimurium transformed with IDO shRNA enhances intratumoral vector colonization and suppresses tumor growth, Cancer Research, 2012, 72 (24):6447-56
  • Anna Israyelyan, Corinna La Rosa, Weimin Tsai, Teodora Kaltcheva, Tumul Srivastava, Jessica Lo, Lia Aquino, Jianqiang Li, Young Kim, Joycelynne Palmer, David Senitzer, John A. Zaia, Andreas Rosenwald, Stephen J. Forman, Ryotaro Nakamura, Don J. Diamond, Detection and preliminary characterization of CD8+T lymphocytes specific for Wilms' tumor antigen in patients with non-Hodgkin lymphoma, Leuk Lymphoma, 2013, 54 (11):2490-2499
  • Nicola R. Hardwick, Mary Carroll, Teodora Kaltcheva, Dajun Qian, Dean Lim, Lucille Leong, Peiguo Chu, Joseph Kim, Joseph Chao, Marwan Fakih, Yun Yen, Jonathan Espenschied, Joshua D. I. Ellenhorn, Don J. Diamond, and Vincent Chung p53MVA Therapy in Patients with Refractory Gastrointestinal Malignancies Elevates p53-Specific CD8+ T-cell Responses, Clin Cancer Res Published OnlineFirst July 1, 2014; doi:10.1158/1078-0432.CCR-13-3361
  • Manuel ER, Chen J, D'Apuzzo M, Lampa MG, Kaltcheva TI, Thompson CB, Ludwig T, Chung V, Diamond DJ, Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Coupled with Enzymatic Depletion of Tumor Hyaluronan Induces Complete Regression of Aggressive Pancreatic Tumors, Cancer Immunol Res. 2015 Sep;3(9):1096-107. doi: 10.1158/2326-6066
  • American Association for Advancement of Science
  • American Chemical Society
  • Pre-doctoral Scholarship, Department of Chemistry, University of Southern California, Los Angeles, CA
  • The Richard Stockton College of New Jersey Foundation, Pomona, NJ Antoinette Bigel Anthropological Studies Endowed Scholarship In Recognition of Outstanding Scholastic Achievement
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