Margarita Gutova

Margarita Gutova, M.D.

  • Associate Research Professor, Department of Developmental & Stem Cell Biology

Margarita Gutova, M.D.

Research Focus :
  • Stem Cell Biology
  • NSC-mediated enzyme/prodrug therapy
  • Pediatric brain tumor models
  • Stem Cell Manufacturing, Terumo BCT
  • Development of neural stem cells for neurodegenerative diseases
  • 2014-present, Associate Research Professor, Department of Developmental and Stem Cell Biology, City of Hope, Duarte, CA' 2010-2014, Assistant Research Professor, Department of Neurosciences, City of Hope, Duarte, CA
  • 2008-2010, Staff Scientist, Department of Neurosciences, Aboody Stem Cell Laboratory, City of Hope, Duarte, CA
  • 2001-2004, Research Fellow and Instructor, Department of Biochemistry, California State University, Los Angeles, CA
  • 1998-2001, Physician, Internal Medicine, Pediatric Medical Academy, St. Petersburg
  • Developmental & Stem Cell Biology
  • Pediatric oncology collaborative disease team

Fellowship

  • 2004-2008, Postdoctoral Research Fellow, Divisions of Hematology/HCT and Neurosciences, City of Hope, Duarte, CA

Residency

  • 1994-1998, Residency, Internal Medicine, Pediatric Medical Academy, St. Petersburg
  • Barish ME, Herrmann K, Tang Y, Argalian Herculian S, Metz M, Aramburo S, Tirughana R, Gutova M, Annala A, Moats RA, Goldstein L, Rockne RC, Gutierrez J, Brown CE, Ghoda L, Aboody KS. Human Neural Stem Cell Biodistribution and Predicted Tumor Coverage by a Diffusible Therapeutic in a Mouse Glioma Model. Stem Cells Transl Med. 2017 Jun;6(6):1522-1532. doi: 10.1002/sctm.16-0397. Epub 2017 May 8. PMID: 28481046 Free Article Similar articles Select item 28345025
  • Gutova M, Goldstein L, Metz M, Hovsepyan A, Tsurkan LG, Tirughana R, Tsaturyan L, Annala AJ, Synold TW, Wan Z, Seeger R, Anderson C, Moats RA, Potter PM, Aboody KS. Optimization of a Neural Stem-Cell-Mediated Carboxylesterase/Irinotecan Gene Therapy for Metastatic Neuroblastoma. Mol Ther Oncolytics. 2016 Dec 14;4:67-76. doi: 10.1016/j.omto.2016.11.004. eCollection 2017 Mar 17. PMID: 28345025 Free PMC Article
  • Li Z, Oganesyan D, Mooney R, Rong X, Christensen MJ, Shahmanyan D, Perrigue PM, Benetatos J, Tsaturyan L, Aramburo S, Annala AJ, Lu Y, Najbauer J, Wu X, Barish ME, Brody DL, Aboody KS, Gutova M. L-MYC Expression Maintains Self-Renewal and Prolongs Multipotency of Primary Human Neural Stem Cells. Stem Cell Reports. 2016 Sep 13;7(3):483-95. PubMed PMID: 27546534; PubMed Central PMCID: PMC5031988.
  • Gutova M, Frank JA, D'Apuzzo M, Khankaldyyan V, Gilchrist MM, Annala AJ, Metz MZ, Abramyants Y, Herrmann KA, Ghoda LY, Najbauer J, Brown CE, Blanchard MS, Lesniak MS, Kim SU, Barish ME, Aboody KS, Moats RA. Magnetic resonance imaging tracking of ferumoxytol-labeled human neural stem cells: studies leading to clinical use. Stem Cells Transl Med. 2013 Oct;2(10):766-75. PubMed PMID: 24014682; PubMed Central PMCID: PMC3785261.
  • Aboody KS, Najbauer J, Metz MZ, D'Apuzzo M, Gutova M, Annala AJ, Synold TW, Couture LA, Blanchard S, Moats RA, Garcia E, Aramburo S, Valenzuela VV, Frank RT, Barish ME, Brown CE, Kim SU, Badie B, Portnow J. Neural stem cell-mediated enzyme/prodrug therapy for glioma: preclinical studies. Sci Transl Med. 2013 May 8;5(184):184ra59. PubMed PMID: 23658244; PubMed Central PMCID: PMC3864887.
  • Gutova M, Shackleford GM, Khankaldyyan V, Herrmann KA, Shi XH, Mittelholtz K, Abramyants Y, Blanchard MS, Kim SU, Annala AJ, Najbauer J, Synold TW, D'Apuzzo M, Barish ME, Moats RA, Aboody KS. Neural stem cell-mediated CE/CPT-11 enzyme/prodrug therapy in transgenic mouse model of intracerebellar medulloblastoma. Gene Ther. 2013 Feb;20(2):143-50. PubMed PMID: 22402322; PubMed Central PMCID: PMC4149468.
  • Najbauer J, Huszthy PC, Barish ME, Garcia E, Metz MZ, Myers SM, Gutova M, Frank RT, Miletic H, Kendall SE, Glackin CA, Bjerkvig R, Aboody KS. Cellular host responses to gliomas. PLoS One. 2012;7(4):e35150. PubMed PMID: 22539956; PubMed Central PMCID: PMC3335155.
  • Zhao D, Najbauer J, Garcia E, Metz MZ, Gutova M, Glackin CA, Kim SU, Aboody KS. Neural stem cell tropism to glioma: critical role of tumor hypoxia. Mol Cancer Res. 2008 Dec;6(12):1819-29. PubMed PMID: 19074827.
  • Gutova M, Najbauer J, Frank RT, Kendall SE, Gevorgyan A, Metz MZ, Guevorkian M, Edmiston M, Zhao D, Glackin CA, Kim SU, Aboody KS. Urokinase plasminogen activator and urokinase plasminogen activator receptor mediate human stem cell tropism to malignant solid tumors. Stem Cells. 2008 Jun;26(6):1406-13. PubMed PMID: 18403751.
  • Gutova M, Najbauer J, Gevorgyan A, Metz MZ, Weng Y, Shih CC, Aboody KS. Identification of uPAR-positive chemoresistant cells in small cell lung cancer. PLoS One. 2007 Feb 28;2(2):e243. PubMed PMID: 17327908; PubMed Central PMCID: PMC1800348.
  • Morshed RA, Gutova M, Juliano J, Barish ME, Hawkins-Daarud A, Oganesyan D, Vazgen K, Yang T, Annala A, Ahmed AU, Aboody KS, Swanson KR, Moats RA, Lesniak MS. Analysis of glioblastoma tumor coverage by oncolytic virus-loaded neural stem cells using MRI-based tracking and histological reconstruction. Cancer Gene Ther. 2015 Jan;22(1):55-61. PubMed PMID: 25525033; PubMed Central PMCID: PMC4293243.
  • Metz MZ, Gutova M, Lacey SF, Abramyants Y, Vo T, Gilchrist M, Tirughana R, Ghoda LY, Barish ME, Brown CE, Najbauer J, Potter PM, Portnow J, Synold TW, Aboody KS. Neural stem cell-mediated delivery of irinotecan-activating carboxylesterases to glioma: implications for clinical use. Stem Cells Transl Med. 2013 Dec;2(12):983-92. PubMed PMID: 24167321; PubMed Central PMCID: PMC3841093.
  • Gutova M, Najbauer J, Chen MY, Potter PM, Kim SU, Aboody KS. Therapeutic targeting of melanoma cells using neural stem cells expressing carboxylesterase, a CPT-11 activating enzyme. Curr Stem Cell Res Ther. 2010 Sep;5(3):273-6. PubMed PMID: 19951251.
  • Thu MS, Najbauer J, Kendall SE, Harutyunyan I, Sangalang N, Gutova M, Metz MZ, Garcia E, Frank RT, Kim SU, Moats RA, Aboody KS. Iron labeling and pre-clinical MRI visualization of therapeutic human neural stem cells in a murine glioma model. PLoS One. 2009 Sep 29;4(9):e7218. PubMed PMID: 19787043; PubMed Central PMCID: PMC2746284.
  • Mooney R, Weng Y, Tirughana-Sambandan R, Valenzuela V, Aramburo S, Garcia E, Li Z, Gutova M, Annala AJ, Berlin JM, Aboody KS. Neural stem cells improve intracranial nanoparticle retention and tumor-selective distribution. Future Oncol. 2014 Feb;10(3):401-15. PubMed PMID: 24559447.

 

Information listed here is obtained from PubMed, a public database; City of Hope is not responsible for its accuracy.

  • 2006, Member, American Association of Cancer Research
  • 2007, Member, Society of Neuro-Oncology
  • 2008, Member, American Society for Gene and Cellular Therapy
  • 2008, Member, Society of Pediatric Neuro-Oncology
  • 2008, Member, International Society of Stem Cell Research
  • 2017 The Best Publication of 2016-2017, ISSCR
  • 2015 Keynote Speaker, Phacilitate Cell & Gene Therapy Forum
  • 2013 Keynote Speaker, Stem Cells & Cellular Therapy Business Summit
  • 2011 IND preparation/assistance: First-in-Human Phase I NSC-Mediated Enzyme/Prodrug Therapy for Glioma and Iron Labeling of NSCs, City of Hope
  • 2011 United States Patent # 20070244046 , USPTO 2011 World Stem Cell Summit Second place award, World Stem Cell Summiy
  • 2009 Keynote Speaker, 10th Bergen Conference on Cancer Research
  • 2006 AACR Fellowship Award, AACR
  • 2002 National Science Foundation Fellowship Award, CSULA
  • 2002 Society for Neuroscience First place award, CSULA
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