Joybelle Medina

Joybelle Medina, M.Sc.

  • Senior Research Associate, Department of Experimental Therapeutics

Joybelle Medina, M.Sc.

Expertise

  • Cloning/Molecular Biology
  • Cell/Tissue Culture
  • Recombinant MVA
  • BAC technology/engineering
  • Clinical Good Manufacturing Practice(GMP)
  • Western Blot
  • Quantitative and RT-PCR
  • Ultracentrifugation
  • Lymphocyte Isolation
  • Fast Protein Liquid Chromatography
  • Flow Cytometry
  • 2001-present, Senior Research Associate, Beckman Research Institute at City of Hope, Duarte, CA
  • 2000, Teaching Assistant, Department of Biochemistry, University of California, Riverside, CA
  • 2002 – University of California, Riverside, Riverside, CA, M.S. in Biochemistry and Molecular Biology
  • 2000 – University of California, Riverside, Riverside, CA,B.S. in Biochemistry
  • Wussow F, Chiuppesi F, Martinez J, Campo J, Johnson E, Flechsig C, et al. Human cytomegalovirus vaccine based on the envelope gH/gL pentamer complex. PLoS pathogens. 2014 Nov;10(11):e1004524. PubMed PMID: 25412505. Pubmed Central PMCID: 4239111.
  • Wussow F, Yue Y, Martinez J, Deere JD, Longmate J, Herrmann A, et al. A vaccine based on the rhesus cytomegalovirus UL128 complex induces broadly neutralizing antibodies in rhesus macaques. J Virol. 2013 Feb;87(3):1322-32. PubMed PMID: 23152525. Pubmed Central PMCID: 3554163.
  • Abel K, Martinez J, Yue Y, Lacey SF, Wang Z, Strelow L, et al. Vaccine-induced control of viral shedding following rhesus cytomegalovirus challenge in rhesus macaques. J Virol. 2011 Mar;85(6):2878-90. PubMed PMID: 21191005. Pubmed Central PMCID: 3067943.
  • Wang Z, Martinez J, Zhou W, La Rosa C, Srivastava T, Dasgupta A, et al. Modified H5 promoter improves stability of insert genes while maintaining immunogenicity during extended passage of genetically engineered MVA vaccines. Vaccine. 2010 Feb 10;28(6):1547-57. PubMed PMID: 19969118. Pubmed Central PMCID: 2821965.
  • La Rosa C, Krishnan A, Longmate J, Martinez J, Manchanda P, Lacey SF, et al. Programmed death-1 expression in liver transplant recipients as a prognostic indicator of cytomegalovirus disease. The Journal of infectious diseases. 2008 Jan 1;197(1):25-33. PubMed PMID: 18171281.
  • Zhou W, Sharma M, Martinez J, Srivastava T, Diamond DJ, Knowles W, et al. Functional characterization of BK virus-specific CD4+ T cells with cytotoxic potential in seropositive adults. Viral immunology. 2007 Sep;20(3):379-88. PubMed PMID: 17931108.
  • Lacey SF, La Rosa C, Zhou W, Sharma MC, Martinez J, Krishnan A, et al. Functional comparison of T cells recognizing cytomegalovirus pp65 and intermediate-early antigen polypeptides in hematopoietic stem-cell transplant and solid organ transplant recipients. The Journal of infectious diseases. 2006 Nov 15;194(10):1410-21. PubMed PMID: 17054071.
  • Wang Z, La Rosa C, Li Z, Ly H, Krishnan A, Martinez J, et al. Vaccine properties of a novel marker gene-free recombinant modified vaccinia Ankara expressing immunodominant CMV antigens pp65 and IE1. Vaccine. 2007 Jan 22;25(6):1132-41. PubMed PMID: 17049414. Pubmed Central PMCID: 1852509.
  • Sharma MC, Zhou W, Martinez J, Krymskaya L, Srivastava T, Haq W, et al. Cross-reactive CTL recognizing two HLA-A*02-restricted epitopes within the BK virus and JC virus VP1 polypeptides are frequent in immunocompetent individuals. Virology. 2006 Jun 20;350(1):128-36. PubMed PMID: 16600320.
  • Gallez-Hawkins G, Thao L, Lacey SF, Martinez J, Li X, Franck AE, et al. Cytomegalovirus immune reconstitution occurs in recipients of allogeneic hematopoietic cell transplants irrespective of detectable cytomegalovirus infection. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2005 Nov;11(11):890-902. PubMed PMID: 16275592.
  • Krymskaya L, Sharma MC, Martinez J, Haq W, Huang EC, Limaye AP, et al. Cross-reactivity of T lymphocytes recognizing a human cytotoxic T-lymphocyte epitope within BK and JC virus VP1 polypeptides. J Virol. 2005 Sep;79(17):11170-8. PubMed PMID: 16103168. Pubmed Central PMCID: 1193623.
  • Lacey SF, Martinez J, Gallez-Hawkins G, Thao L, Longmate J, Haq W, et al. Simultaneous reconstitution of multiple cytomegalovirus-specific CD8+ cell populations with divergent functionality in hematopoietic stem-cell transplant recipients. The Journal of infectious diseases. 2005 Mar 15;191(6):977-84. PubMed PMID: 15717275.
  • La Rosa C, Wang Z, Lacey SF, Markel SF, Sharma MC, Martinez J, et al. Characterization of host immunity to cytomegalovirus pp150 (UL32). Human immunology. 2005 Feb;66(2):116-26. PubMed PMID: 15694996.
  • Lacey SF, Villacres MC, La Rosa C, Wang Z, Longmate J, Martinez J, et al. Relative dominance of HLA-B*07 restricted CD8+ T-lymphocyte immune responses to human cytomegalovirus pp65 in persons sharing HLA-A*02 and HLA-B*07 alleles. Human immunology. 2003 Apr;64(4):440-52. PubMed PMID: 12651070.
  • Lacey SF, Gallez-Hawkins G, Crooks M, Martinez J, Senitzer D, Forman SJ, et al. Characterization of cytotoxic function of CMV-pp65-specific CD8+ T-lymphocytes identified by HLA tetramers in recipients and donors of stem-cell transplants. Transplantation. 2002 Sep 15;74(5):722-32. PubMed PMID: 12352893.
  • Martinez J, Dugaiczyk LJ, Zielinski R, Dugaiczyk A. Human genetic disorders, a phylogenetic perspective. Journal of molecular biology. 2001 May 11;308(4):587-96. PubMed PMID: 11350162.
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