Mingye Feng, Ph.D.
- Assistant Professor, Department of Immuno-Oncology
Mingye Feng, Ph.D.
Research Focus :
- Macrophage-mediated immunosurveillance
- 2017 - present, Assistant Professor, Department of Immuno-Oncology, Beckman Research Institute of City of Hope, Duarte, CA
- 2016 - 2017, Instructor, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA
- 2011, Ph.D., Cellular and Molecular Physiology, Johns Hopkins School of Medicine, Baltimore, MD
- 2004, B.S., Biological Sciences, University of Science and Technology of China, Hefei, Anhui, China
- 2012 - 2016, Postdoctoral Fellowship, Damon Runyon Cancer Research Foundation
- 2011 - 2016, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA
The ability to escape from surveillance by the immune system is regarded as one of the essential hallmarks of cancer cells. While the functions of lymphocytes (T, B and NK cells) in tumor immunosurveillance have been studied for decades, the roles of macrophages on tumor cell elimination have only begun to be explored. Macrophages detect and eliminate tumor cells via a process of macrophage-mediated cell phagocytosis called “programmed cell removal” (PrCR). Recent studies showed that blockade of a “don't eat me” signal CD47 on malignant hematopoietic and various solid tumor cells enabled their phagocytosis by macrophages and prevented their engraftment in mice lacking T, B and NK cells, indicating a key role of macrophages in tumor surveillance and elimination. While inducing macrophage-mediated immunosurveillance holds considerable promise for the treatment of various cancers, its underlying mechanism remains largely unknown.
My laboratory is focused on three fundamental questions: First, how do macrophages recognize tumor cells and target them for phagocytosis? Second, at different stages of cancer development, do macrophages exert multiple layers of extrinsic PrCR pressure to tumor cells, and how do tumor cells react and develop self-protective mechanisms? Third, what are the intrinsic regulatory programs in macrophages that regulate their functions in PrCR?
Our overall objective is to combine in vitro and in vivo approaches to explore the underlying mechanisms of macrophage-mediated immunosurveillance and its therapeutic potential. The identification and understanding of such important mechanisms should shed light on the basic mechanisms of tumor cell immune evasion, and enable the development of novel anti-cancer immunotherapies.
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We are seeking highly motivated biologists, chemists and physicians from diverse backgrounds to join our research team.
We now have positions open for two postdoctoral fellows.
- For postdoctoral candidates, please submit a cover letter, CV and names of three referees to Dr. Mingye Feng ([email protected]). We are currently looking for highly motivated and talented candidates in but not limited to:
- Cancer Biology/Cell Biology
- Zhu F, Feng M, Rahul S, Seita J, Mori Y, and Weissman IL. Screening for genes that regulate the differentiation of human megakaryocytic lineage cells. Proc Natl Acad Sci USA 2018 Aug 27.
- Folkes AS, Feng M, Zain JM, Abdulla F, Rosen ST, and Querfeld C. Targeting CD47 as a cancer therapeutic stragety: the cutaneous T-cell lymphoma experience. Curr Opin Oncol. 2018 Sep; 30 (5): 332-337.
- Feng M*#, Marjon KD*, Zhu F*, Weissman-Tsukamoto R*, Levett A, Sullivan K, Kao KS, Markovic M, Bump PA, Jackson HM, Choi TS, Chen J, Banuelos AM, Liu J, Gip P, Cheng L, Wang D, and Weissman IL#. Programmed cell removal by calreticulin in tissue homeostasis and cancer. Nat Commun 2018 Aug 10; 9 (1): 3194. (*equal contribution, #co-corresponding author).
- Weiskopf K, Schnorr PJ, Pang WW, Chao MP, Chhabra A, Seita J, Feng M, and Weissman IL. Myeloid Cell Origins, Differentiation, and Clinical Implications. Microbiol Spectr 2016 Oct; 4 (5).
- Feng M, Chen JY, Weissman-Tsukamoto R, Volkmer JP, Ho PY, McKenna KM, Cheshier S, Zhang M, Guo N, Gip P, Mitra SS, and Weissman IL. Macrophages eat cancer cell using their own calreticulin as a guide: roles of TLR and Btk. Proc Natl Acad Sci USA 2015 Feb 17; 112 (7): 2145-50.
- Feng M, and Rao R. New insights into store-independent Ca2+ entry: secretory pathway calcium ATPase in normal physiology and cancer. Int J Oral Sci 2013 Jun; 5 (2): 71-4.
- Leitch S*, Feng M*, Muend S, Braiterman LT, Hubbard AL, and Rao R. Vesicular distribution of Secretory Pathway Ca2+-ATPase isoform1 (SPCA1) and a role in manganese detoxification in liver-derived polarized cells. Biometals 2011 Feb; 24 (1): 159-70. (*equal contribution)
- Feng M, Grice DM, Faddy HM, Nguyen N, Leitch S, Wang Y, Muend S, Kenny PA, Sukumar S, Roberts-Thomson SJ, Monteith GR, and Rao R. Store-independent activation of Orai1 by SPCA2 in mammary tumors. Cell 2010 Oct 1; 143 (1): 84-98.
- Wang X, Ye L, McKinney CC, Feng M, and Maloney PC. Cysteine scanning mutagenesis of TM5 reveals conformational changes in OxlT, the oxalate transporter of Oxalobacter formigenes. Biochemistry 2008 May 27; 47 (21): 5709-17.
- Faddy HM, Smart CE, Xu R, Lee GY, Kenny PA, Feng M, Rao R, Brown MA, Bissell MJ, Roberts-Thomson SJ, and Monteith GR. Localization of plasma membrane and secretory calcium pumps in the mammary gland. Biochem Biophys Res Commun 2008 May 9; 369 (3): 977-81.
- Xiang M, Feng M, Muend S, and Rao R. A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension. Proc Natl Acad Sci USA 2007 Nov 20; 104 (47): 18677-81.
- 2015, Damon Runyon-Dale F. Frey Award for Breakthrough Scientists, Damon Runyon Cancer Research Foundation
- 2015, K99/R00 Pathway to Independence Award, National Cancer Institute of the National Institutes of Health
- 2011, The Martin and Carol Macht Doctoral Research Award, The Johns Hopkins University, School of Medicine