An NCI-designated Comprehensive Cancer Center
Kevin Morris

Kevin Morris, Ph.D.

Professor, Center for Gene Therapy
Research Focus
  • Understanding the role of non-coding RNA in life, evolution and selection, and to use that knowledge to develop novel therapies for AIDS, cancer and other diseases.
Email: [email protected]

Research Teams

  • Gene Therapy

"I really am stoked on learning about the basic fabric of our existence ... the complexity is mind-boggling." For more than a decade, Kevin Morris, Ph.D. has been one of the brightest lights in RNA research.

Morris was the first to recognize unique properties of non-coding RNA; he is considered an international leader in the field.

The goal of his work, in his words, is “to understand the role of non-coding RNA in life, evolution and selection.” and to use that knowledge to develop novel therapies for AIDS, cancer and other diseases.

At the Center for Gene Therapy, Morris focuses on manipulating RNA in a variety of ways to control and repress HIV-1.

Morris has led research laboratories at the renowned Scripps Research Institute in La Jolla, California as well as the University of New South Wales, Australia. His relationship with City of Hope began in 2004 with researcher and adjunct professor positions at the Beckman Research Institute of City of Hope.


City of Hope Comprehensive Cancer Center, 1500 East Duarte Road

Duarte, CA 91010

Morris K.V., S. W-L. Chan, S.E. Jacobsen, D.J. Looney. Small interfering RNA-induced transcriptional silencing in human cells. Science, 2004, Vol. 305, 1289-1292. PMID:  15297624.

Morris K.V., Santoso S, Turner AM, Pastori C, Hawkins PG. Bidirectional transcription directs both transcriptional gene activation and suppression in human cells. PLoS Genet. 2008 Nov;4(11):e1000258. PMID:  19008947/PMCID:  2576438.

Weinberg, M.S., L.M. Villeneuve, A. Ehsani, L. Aagaard, Z. Chen, A.D. Riggs, J.J. Rossi and K.V. Morris. The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells. RNA. 2006, Vol. 12, 256-262. PMID:  16397511.

Han J, D. Kim, and K.V. Morris Promoter-associated RNA is required for RNA-directed transcriptional gene silencing in human cells. PNAS, 2007 July 24(104):30. PMID:  17640892/PMCID:  1924466.

K.V. Morris and J. S. Mattick. The Rise of Regulatory RNA. Nature Reviews Genetics 2014 Apr 29. doi: 10.1038/nrg3722. PMID:24776770.

Turner AM, De La Cruz J, Morris K.V., Mobilization-competent Lentiviral Vector-mediated Sustained Transcriptional Modulation of HIV-1 Expression. Mol Ther. 2008 Dec 9;. PMID: 19066594

Weinberg MS, Morris KV. A New World Order: Tailored Gene Targeting and Regulation Using CRISPR. Molecular Therapy. 2014 May;22(5):893. PMID: 24787973

Turner AM, Ackley AM, Matrone MA, Morris KV. Characterization of an HIV-targeted transcriptional gene-silencing RNA in primary cells. Hum Gene Ther. 2012 May;23(5):473-83. PMID:22122263

For a complete List of Published Work see my bibliography:

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