An NCI-designated Comprehensive Cancer Center
Eun Jin Oh bio

Eunjin Oh, Ph.D.

Assistant Research Professor, Department of Molecular & Cellular Endocrinology
Research Focus
  • Diabetes and aging
Other Languages Spoken
  • Korean

Research Teams

  • Molecular & Cellular Endocrinology

Locations

City of Hope Comprehensive Cancer Center, 1500 East Duarte Road

Duarte, CA 91010

  • Oh E., Miller R.A., and Thurmond D.C. (2015) Syntaxin4 overexpression ameliorates effects of aging and high fat diet on glucose control and extends lifespan. Cell Metab. 22(3) 499-507.
  • Thurmond D.C., Oh E., and Miller R.A. (2015) Potential site effects and transgene expression discrepancies in mouse lifespan studies. Cell Metab. 22(3) 346-347.
  • Blue E.K., Ballman K., Boyle F., Oh E., Kono T., Thurmond D.C., Evans-Molina C., and Haneline L.S. (2014) Fetal hyperglycemia and a high fat diet contribute to aberrant glucose tolerance and hematopoiesis in adulthood. Pediatrics Res. 77(2):316-325.
  • Oh E., Stull N.D., Mirmira R.G., and Thurmond D.C. (2014) Syntaxin 4 upregulation improves islet function and transplantation success. J Clin Endocrinol Metab. 99(5):E866-870.
  • Ramalingam L., Oh E., and Thurmond D.C. (2014) Doc2b enrichment enhances glucose homeostasis via potentiation of insulin secretion and peripheral insulin sensitivity. Diabetologia 57(7):1476-84.
  • Ramalingam L., Yoder S.M., and Oh E., and Thurmond D.C. (2014) Munc18c:  A Controversial Regulator of Peripheral Insulin Action. Trends Endocrinol Metab S1043-2760(14). # invited review
  • Ramalingam L., Oh E., and Thurmond D.C. (2013) Novel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates. Cell Mol Life Sci. 70:2815-2834 # invited review
  • Oh E., Kalwat M.A., Kim M.J., Verhage M., and Thurmond D.C. (2012). Munc18-1 Regulates First-Phase Insulin Release by Promoting Granule Docking to Multiple Syntaxin Isoforms. J Biol Chem. 287(31):25821-33.
  • Ramalingam L., Oh, E., Yoder S.M., Brozinick J.T., Kalwat M.A., Groffen A.J., Verhage M., and Thurmond D.C.  (2012). Doc2b is essential for glucose homeostasis in vivo via its Munc18c-sequestering action. Diabetes 61:2424-2432.
  • *Jewell, J.L., * Oh, E., Ramalingam, L., Kalwat, M., Tagliabracci, V., Tackett, L., Elmendorf, J.S. and Thurmond, D.C. (2011). Munc18c Phosphorylation by the Insulin Receptor Links Cell Signaling Directly to SNARE Exocytosis. J Cell Biol 193(1):185-99. *;The authors equally contributed to this paper. #Note: paper selected for editorial audioblog.
  • Kepner, E.M., Yoder, S., Oh, E., Kalwat, M., Wang, Z. and Thurmond, D.C. (2011). Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion. AJP-Endo and Metab.  301:E1071-E1080. #Note: paper selected for editorial commentary.
  • Wang, Z., Oh, E., Chernoff, J., Clapp, D.W. and Thurmond, D.C. (2011). The Cdc42-Pak1 signaling pathway controls second-phase insulin release in human islets: aberrant whole-body glucose homeostasis in Pak1-deficient mice. J Biol Chem. 286(48) 41359-67.
  • Jewell, J.L., Oh, E., and Thurmond, D.C. (2010). Exocytosis mechanisms underlying insulin release and glucose uptake: Munc18c and Syntaxin 4. AJP- Regulatory, Integrative, and Comparative Physiology 298(3):R517-31. # invited review
  • Oh, E. and Thurmond, D.C. (2009). Munc18c depletion selectively impairs the sustained phase of insulin release Diabetes 58, 1165-1174.
  • Jewell, J.L., Oh, E., Bennett, S.M., Meroueh, S.O. and Thurmond, D.C. (2008). The tyrosine phosphorylation of Munc18c induces a switch in binding specificity from Syntaxin 4 to Doc2β. J Biol Chem 283:21734-21746.
  • Jewell, J.L., Luo, W., Oh, E., Wang, Z. and Thurmond, D.C. (2008). Filamentous actin regulates insulin exocytosis through direct interaction with Syntaxin 4. J Biol Chem 283:10716-10726.
  • Oh, E., Heise, C.J., English, J.M., Cobb, M.H. and Thurmond, D.C. (2007). WNK1 is a Novel Regulator of Munc18c-Syntaxin 4 Complex Formation in SNARE-mediated Vesicle Exocytosis.  J Biol Chem 282:32613-22.
  • Ke, B., Oh, E. and Thurmond, D.C. (2007). Doc2β is a novel Munc18c-interacting partner and positive effector of Syntaxin-4 mediated exocytosis. J Biol Chem 282:21786-97.
  • Wang, Z., Oh, E. and Thurmond, D.C. (2007). Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion. J Biol Chem 282:9536-9546.
  • Oh, E. and Thurmond, D.C. (2006). The stimulus-induced tyrosine-phosphorylation of Munc18c facilitates vesicle exocytosis. J Biol Chem 281:17624-17634.
  • Oh, E., Spurlin, B.A., Pessin, J.E., and Thurmond, D.C. (2005). Munc18c Heterozygous Knockout Mice Display Increased Susceptibility for Severe Glucose Intolerance. Diabetes, 54:635-647.
  • Hwang, M., Kim, Y., Choi, N., Park, J., Oh, E., Kwon, E., Yamaguchi, M., and Yoo, M. (2002) The caudal homeodomain protein activates Drosophila E2F gene expression. Nucleic Acids Res. 30(23): 5029–5035.
  • Oh, E., Park, J., Cho, M., Lee, W., Choi, Y., and Yoo, M. (2002) The Caudal-related homeodomain protein CDX1 activates proliferating cell nuclear antigen expression in hepatocellular and colorectal carcinoma cells. Int. J. Onc. 20: 23-29.
  • Park, S., Oh, E., Yoo, M., and Lee, S. (2001) Involvement of DNA dependent protein kinase in regulation of stress-induced JNK activation. DNA Cell Biol. 10: 637-645.
  • Park, J., Oh, E., Choi, Y., Kang, C., Kang, H., Kim, D., Kang, K., and  Yoo, M. (2001). Synergistic effects of dexamethasone and genistein on the expression of Cdk inhibitor p21WAF1/CIP1 in human hepatocellular and colorectal carcinoma cells. Int. J. Onc. 18: 997-1002.
  • *Kwon, E., *Oh, E., Kim, Y., Hirose, F., Ohno, K., Nishida, Y., Matsukage, A., Yamaguchi, M., and Yoo, M. (2001).  E2F-dependent transcription of the raf proto-oncogene during Drosophila development. Nucleic Acids Res. 29: 1808-1814. *;The authors equally contributed to this paper.
  • Kwon, E., Park, H., Kim, Y., Oh, E., Nishida, Y., Matsukage, Y., Yoo, M., and Yamaguchi, M. (2000). Transcriptional regulation of Drosophila raf proto-oncogene by Drosophila STAT during development and in immune response. J. Biol. Chem. 275: 19824-19830.
     
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