Partrick Fueger, M.D., Ph.D. - Profile Photo

Patrick Fueger, Ph.D.

  • Associate Professor, Department of Molecular & Cellular Endocrinology

Patrick Fueger, Ph.D.

  • 2016, Director, Comprehensive Metabolic Phenotyping Core, BRI at City of Hope
  • 2016, Associate Professor, Department of Molecular and Cellular Endocrinology, Beckman Research Institute (BRI) at City of Hope
  • 2015-2016, Program Co-Director, Bioengineering Interdisciplinary Training for Diabetes Research, IUSM/Purdue
  • 2015-2016, Associate Professor (adjunct), Department of Cellular & Integrative Physiology, IUSM
  • 2015-2016, Associate Professor, Department of Pediatrics, Indiana University School of Medicine (IUSM)
  • 2009-2015, Assistant Professor (adjunct), Department of Cellular & Integrative Physiology, IUSM
  • 2009-2015, Assistant Professor, Department of Pediatrics, Indiana University School of Medicine (IUSM)

Degrees

  • 2004, Ph.D., Molecular Physiology & Biophysics
  • 1999, MS, Human Kinetics, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin
  • 1994, BS, Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin

Fellowship

  • 2004-2009, Pharmacology & Cancer Biology, Duke University, Durham, NC
The overall goal of my laboratory is to identify and characterize novel molecular regulators of functional beta cell mass in vitro and extrapolate this work to the in vivo setting.  For the proposed work we are particularly interested in the endogenous feedback inhibitor of EGFR Mig6 (a.k.a. errfi1, Gene 33, or RALT).  The proposed work evolved out of experiments conducted as part of my K99/R00 award, which has helped us define the roles of molecular brakes and accelerators of beta cell proliferation.  We have validated, in the context of the beta cell, that Mig6 blocks replication.  Interestingly, we have discovered that molecular brakes for proliferation such as Mig6 can also impair beta cell survival as well as function.  Thus, Mig6 can be classified as a multi-regulator of functional beta cell mass.  

My training as a post-doctoral fellow in Dr. Christopher Newgard’s laboratory provided a solid foundation for investigating islet biology, and my doctoral work in Dr. David Wasserman’s laboratory established my expertise with in vivo experimentation.  My laboratory currently consists of one research analyst and three graduate students; we are actively recruiting a post-doctoral fellow for this project.  Thus, we have adequate personnel to perform the proposed studies.  In addition, I work within a group of five islet biology labs within a larger pediatric research center utilizing a variety of model systems and equipped with all of the tools needed to study islet biology both in vitro and in vivo.  Importantly, I have a personal commitment to diabetes research as myself and two brothers have type 1 diabetes, and I have been involved with camps for children with diabetes for over 30 years.  I use this passion and absolute commitment to fuel my efforts in the laboratory.
  • 1999-present, American Physiological Society (APS), Member
  • 1999-present, American Diabetes Association (ADA), Member
  • 2015, New Investigator Award (Endocrinology and Metabolism Section, APS)
  • 2007, Pathway to Independence Award (K99/R00 NIH)
  • 2005, Postdoctoral Fellowship Award (Juvenile Diabetes Research Foundation)
  • 2005, Novel Disease Model Award (Liaison with Industry Committee, APS)
  • 2005, Mead Johnson Research Award in Endocrinology and Metabolism (APS)
  • 2004, Virendra B. Mahesh Award of Excellence in Endocrinology (APS)
  • 2003 Novel Disease Model Award (Liaison with Industry Committee, APS)
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