Radany-Eric2

Eric H. Radany, M.D., Ph.D.

  • Associate Clinical Professor, Department of Radiation Oncology
  • Radiation Oncologist

Eric H. Radany, M.D., Ph.D.

Clinical Specialties
  • Radiation Oncology
Areas of Expertise
  • Pediatric Cancers
  • Breast Cancer
  • Brain and Central Nervous System Tumors
  • Stereotactic Radiosurgery
  • Image-guided Intensity Modulated Radiation Therapy/TomoTherapy
  • Electronic Brachytherapy
Research Focus
  • Radiation Treatment for Breast, Brain and Pediatric Cancers
  • Radiobiology

Eric Radany, M.D., Ph.D., was winning awards for his clinical and investigative skills even before he finished medical school. At City of Hope since 2004, Dr. Radany has over 25 years' experience as a radiation oncologist, and a well-earned reputation as an acknowledged expert in the field.

His expertise includes such advanced procedures as stereotactic radiosurgery, conformal radiotherapy, image-guided radiotherapy and TomoTherapy. His primary interest is in radiation biology, using systemic agents to sensitize the effects of radiation against cancer. Dr. Radany also treats pediatric cancers and brain cancers.

As a nationally recognized authority, Dr. Radany has authored dozens of scholarly papers and serves as editor or reviewer on several prestigious scientific journals. He is a sought-after expert and an anchor of our radiation oncology team.

  • 2004 - Present - Clinical Associate Professor and Attending Physician, Department of Radiation Oncology, City of Hope, Duarte, CA
  • 2004 - 2009 - Adjunct Professor in Radiation Oncology, University of California, Irvine, Irvine, CA
  • 1999 - 2004 - Assistant Professor and Attending Physician in Radiation Oncology, In Line Series ,University of California, Irvine, Irvine, CA
  • 1998 - 1999 - Attending Radiation Oncologist, Veteran’s Administration Medical Center, MI
  • 1992 - 1999 - Assistant Professor and Attending Physician in Radiation Oncology, University of Michigan, Ann Arbor, MI
  • Brain Tumor
  • Breast Cancer
  • Pediatric Cancers
  • Pituitary Disorders

Locations

Duarte

1500 East Duarte Road, Duarte, CA, 91010

Get Directions

Phone :  626-256-4673

Degrees

  • 1978 -1984, Stanford University School of Medicine, Stanford, CA, combined M.D./Ph.D.
  • 1977 - 1978 M.S. Chemistry University of Rochester, Rochester NY
  • 1973 -1977, University of Rochester, Rochester, NY, B.A., Chemistry and Biology

Fellowship

  • 1989 -1992, GW Hooper Foundation, University of California, San Francisco, CA, Fellowship

Residency

  • 1986 -1989, University of Pennsylvania School of Medicine, Philadelphia, PA, Residency, Radiation Oncology
  • 1984 -1986, National Cancer Institute, National Institute of Health, Residency, Anatomic Pathology

Information listed here is obtained from Pubmed, a public database; City of Hope is not responsible for its accuracy.

Books
 
1.      Radany EH.  Experimental Investigation of a Thermodynamic Model for the Control of Protein Turnover. M.S. dissertation. University of Rochester, Rochester NY, 1978.
 
2.      Radany EH. The Pyrimidine Dimer-DNA Glycosylase Activity from Bacteriophage T4 Program in Cancer Biology. Ph.D. dissertation, Stanford University, Stanford CA, 1987.
 
Book Chapters
 
A.      Single Author, edited book
 
1.           Radany EH. Gene therapy of cancer. In: Philips TL, Libel SA, eds. Textbook of Radiation Oncology,.  Philadelphia: W B Saunders, 1998.
 
B.      Multiple Authors, edited book, Peer Reviewed
 
1.           Friedberg EC, Bonura T, Reynolds R, Radany EH. Some aspects of the enzymology of DNA repair. In: Alacevik M, ed. Environmental Mutagenesis. Amsterdam, Elsevier/North-Holland: Biomedical Press, 1980.
 
2.           Radany EH, Love JD, Friedberg EC. The use of direct photo-reversal of UV-irradiated DNA for the demonstration of pyrimidine dimer-DNA glycosylase activity. In:  Seeberg E, Kleppe K, eds. Chromosome Damage and Repair. New York: Plenum Press, 1981.
 
3.           Friedberg EC, Bonura T, Radany EH, Love JD. Enzymes that incise damaged DNA. In:  Boyer PD, ed.  The Enzymes. New York: Academic Press, 1981.
 
Journal Articles, Peer Reviewed
 
1.           McLendon G, Radany EH. Is protein turnover thermodynamically controlled? J Biol Chem 253:6335-6337, 1978.
 
2.           Radany EH, Friedberg EC. A pyrimidine dimer DNA-glycosylase activity associated with the v gene product of bacteriophage T4. Nature 286:182-185, 1980.
 
3.           Friedberg EC, Anderson CT, Bonura T, Cone R, Radany EH, Reynolds RJ. Recent developments in the enzymology of excision repair of DNA. Prog Nuc Acid Res Mol Biol 26:197-215, 1981.
 
4.           Friedberg EC, Bonura T, Love JD, McMillan S, Radany EH, Schultz RA. The repair of DNA damage:  Recent developments and new insights. J Supramol Struct Cell Biochem 16:91-103, 1981.
 
5.           McMillan S, Edenberg HJ, Radany EH, Friedberg RC, Friedberg EC. Den V gene of bacteriophage T4 codes for both pyrimidine dimer-DNA glycosylase and apyrimidinic endonuclease activities. J Virol 40:211-223, 1981.
 
6.           Radany EH, Friedberg EC. Demonstration of pyrimidine dimer-DNA glycosylase activity in vivo:  Bacteriophage T4-infected Escherichia coli as a model system. J Virol 41:88-96, 1982.
 
7.           Bonura T, Radany EH, McMillan S, Love JD, Schultz RA, Edenberg HJ, Friedberg EC.  Pyrimidine dimer-DNA glycosylases: Studies on bacteriophage T4-infected and on uninfected Escherichia coli.  Biochemie 64:643-654, 1982.
 
8.           Radany EH, Friedberg EC. Measurement of repair patch size by quantitation of nucleotides excised during DNA repair in vivo. J Virol 47:367-369, 1983.
 
9.           Radany EH, Naumovski L, Love JD, Gutekunst K, Hall D, Friedberg EC. Physical mapping and complete nucleotide sequence of the den V gene of bacteriophage T4. J Virol 52:846-856, 1984.
 
10.       Restrepo C, Macher AM, Radany EH. Disseminated extraintestinal isosporiasis in a patient with acquired immune deficiency syndrome. Am J Clin Pathol 87:536-542, 1987.
 
11.    Radany EH, Nguyen HT, Minton KW.  Activities involved in base excision repair of bacteriophage T4 and lambda DNA in vivo. Mol Gen Genet 209:83-89, 1987.
 
12.    Hsieh C-L, McCloskey RP, Radany E, Lieber RM. V(D)J recombination: evidence that a replicative mechanism is not required. Molecular and Cellular Biol 11:3972-3977, 1991.
 
13.    Radany EH, Brenner M, Besnard F, Bigornia V, Bishop JM, Deschepper CF. Directed establishment of rat brain cell lines with the phenotypic characteristics of type 1 astrocytes. Proc Natl Acad Sci 89:6467-6471, 1992.
 
14.    Canman CE, Radany EH, Parsels LA, Davis MA, Lawrence TS, Maybaum J. Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridine triphosphatase. Cancer Res 54:2296-2298, 1994.
 
15.    Dietrich WF, Radany EH, Smith JS, Bishop JM, Hanahan D, Lander ES. Genome-wide search for loss of heterozygosity in transgenic mouse tumors reveals candidate tumor suppressor genes on chromosomes 9 and 16.  Proc Natl Acad Sci 91:9451-9455, 1994.
 
16.    Chang CL, Zhu X, Thoraval DH, Ungar D, Rawwas J, Hora N, Strahler JR, Hanash SM, Radany EH. NM23-H1 mutation in neuroblastoma.  Nature 370:335-336, 1995.
 
17.    Pu A, Sandler HM, Radany EH, Blaivas M, Page MA, Greenbert HS, Junck LR, Ross DA. Low grade gliomas: Preliminary analysis of failure patterns among patients treated using 3-D conformal external beam radiotherapy.  Int J Radiat Oncol Biol Phys  31:461-466, 1995.
 
18.    Lawrence TS, Davis MA, Chang E, Canman CE, Maybaum J, Radany EH. Lack of dependence of FD Urd-mediated radiosensitization on cytotoxicity. Radiat Res 143:281-285, 1995.
 
19.    Thoraval D, Asakawa J, Kodaira M, Chang C, Radany E, Kuick R, Lamb B, Richardson B, Neel J, Glover T, Hanash S. A methylated human 9 Kb repetitive sequence on acrocentric chromosomes is homologous to a subtelomeric repeat in chimpanzees. Proc Natl Acad Sci 93:4442-4447, 1996.            
 
20.    Radany EH, Hong K, Keshavarzi S, Lander ES and Bishop JM. Mouse Mammary Tumor Virus/v-Ha-ras transgene-induced mammary tumors exhibit strain-specific allelic loss on mouse chromosome 4. Proc Natl Acad Sci U S A 94:8664-9, 1997.
 
21.    Radany EH, Malanoski G, Ambulos N, Friedberg EC, Yasbin RE. Transfection enhancement in Bacillus subtilis displays features of a novel DNA repair pathway I: DNA base and nucleolytic specificity. Mutation Research  384:107-20, 1997.
 
22.    Radany EH, Malanoski G, Ambulos N, Friedberg EC, Yasbin RE. Transfection enhancement in Bacillus subtilis displays features of a novel DNA repair pathway. II: Host constitutive expression, repair DNA synthesis, and in vitro activity. Mutation Research  384:121-34, 1997.
 
23.    Harris KF, Christensen JB, Radany EH, Imperiale MJ. Novel mechanism of E2F induction by BK virus Large-T antigen: requirement of both the pRB-binding and the J domains. Molecular and Cellular Biol. 18:1746-56, 1998.
 
24.    Ten Haken RK, Fraass BA, Lichter AS, Marsh LH, Radany EH, Sandler HM. A brain tumor dose escalation protocol based on effective dose equivalence to prior experience Int. J. Radiat Oncol. Biol. Physics 42:137-141, 1998.
 
25.    Parsels LA, Parsels JD, Wagner LM, Loney TL, Radany EH, Maybaum J. Mechanism and  pharmacological specificity of dUTPase-mediated protection from DNA damage and cytotoxicity in human tumor cells. Cancer Chemotherapy and Pharmacology 42:357-362, 1998.
 
26.    Lee SW, Fraass BA, Marsh LH, Herbort K, Gebarski SS, Martel MK, Radany EH, Lichter AS, Sandler HM.  Patterns of failure following high-dose 3-D conformal radiotherapy for high-grade astrocytomas -- A quantitative dosimetric study.  International Journal of Radiation Oncology, Biology and Physics 43:79-88, 1999.
 
27.    Ignatoski KM, LaPointe AJ, Radany EH, Ethier SP: ErbB-2 overexpression in human mammary epithelial cells confers growth factor independence. Endocrinology 140:3615-3622, 1999.
 
28.    Radany EH, Dornfeld KJ, Sanderson RJ, Savage MK, Majumdar A, Seidman MM, Mosbaugh DW: Increased Spontaneous Mutation Frequency in human cells expressing the phage PBS2-encoded inhibitor of uracil-DNA glycosylase. Mutation Research DNA Repair 461: 41-58, 2000.
 
29.    Monk B, Burger RA, Parker R, Radany EH, Redpath JL, Fruehauf JP. Development of an in vitro chemo-radiation response assay for cervical carcinoma. Gynecol Oncol 87:193-199, 2002.
 
30.    Kaiser A, Schultheiss TE, Wong J, Smith DD, Han C, Vora NL, Pezner RD, Chen YJ, Radany EH. Pitch, Roll,  and Yaw Variations in Patient Positioning. Int. J. Radiat. Oncol. Biol. Phys.  66:949-55, 2006.
 
31.    Do L, Pezner R, Radany EH, Liu A, Staud C, Badie B. Resection followed by stereotactic radiosurgery to resection cavity for intracranial metastases. Int. J. Radiat. Oncol. Biol. Phys. 73:486-91, 2009.
 
32.    Chen, X., Wong, P., Radany, E., Wong, J.Y.C.: HDAC inhibitor valproic acid induces p53-dependent radiosensitization of colon cancer cells. Cancer Biotherapy and Radiopharmaceuticals 24(6): 689-699, 2009.
 
33.    Chen, X., Wong J.Y., Wong P, Radany EH. Low dose valproic acid enhances radiosensitivity of prostate cancer through acetylated p53-dependent modulation of mitochondrial membrane potential and apoptosis. Molecular Cancer Research 9: 448-61, 2011
 
34.   Chen X., Wong P., Radany E.H., Stark J.M., Laulier C., Wong J.Y. Suberoylanilide hydroxamic acid as a radiosensitizer through modulation of RAD51 protein and inhibition of homology-directed repair in multiple myeloma. Molecular Cancer Research 10:1052-64, 2012.
 
35.    Wong J.Y., Forman S., Somlo G., Rosenthal J., Liu A., Schultheiss T., Radany E., Palmer J., Stein A. Dose Escalation of Total Marrow Irradiation With Concurrent Chemotherapy in Patients With Advanced Acute Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation. Int J Radiat Oncol Biol Phys. 85:148-56, 2012
 
36.    Kim DH, Schultheiss TE, Radany EH, Badie B, Pezner RD. Clinical outcomes of patients treated witha  second course of sterotactic radiosurgery for locally or regionally recurrent brain metastases after prior stereotactic radiosurgery. J Neurooncol 115:3737-43 2013
 
37. Chen X, Radany EH, Wong P, Ma S, Wu K, Wang B, Wong JY. Suberoylanilide hydroxamic acid induces hypersensitivity to radiation therapy in acute myelogenous leukemia cells expressing constitutively active FLT3 mutants. PLoS One 8:e84515 2013

         

 
  • 2002 - UCI COM candidate for Burroughs-Wellcome Fund Clinical Scientist Award in Translational Research
  • 2001 - UCI COM candidate for Burroughs-Wellcome Fund Clinical Scientist Award in Translational Research
  • 1991 – 1994 - NCI Clinical Investigator Award
  • 1989 - ASCO Young Investigator Award American Society of Clinical Oncology
  • 1989 – 1991 - ASTRO Research Fellowship American Society for Therapeutic Radiology and Oncology
  • 1989 – 1991 - RSNA Research Fellowship Radiological Society of North America
  • 1989 – 1991 - Anna Fuller Fund Postdoctoral Fellowship
  • 1980 - NATO/EMBO Travel Award supporting attendance for presentation at NATO ASI/EMBO Lecture Course Chromosome Damage and Repair, Godoysund, Norway
  • 1978 - Medical Scientist Training Program USPHS Fellowship Grant
  • 1977 - B.A. cum laude
  • Phi Beta Kappa (University of Rochester)
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