Experimental Therapeutics - Sarah Mackenzie

Sarah Mackenzie-Dyck, Ph.D.

  • Postdoctoral Fellow, Department of Experimental Therapeutics

Sarah Mackenzie-Dyck, Ph.D.

Research Focus :
  • Develop biological-based immunotherapeutics that target and eliminate solid or hematopoietic malignancies
  • Establish methods to deliver vaccines and immunotherapeutics in order to induce or enhance long-term anti-tumor responses
  • Conduct pre-clinical studies to provide supporting data for clinical translation of novel, effective therapeutic approaches
  • Evaluation of immune responses to vaccination and the efficacy of immunotherapeutics within the context of existing pathology using traditional assays and newer technologies to correlate clinical findings with differences at the level of the genome, transcriptome and proteome.
  • 2017–Current, Postdoctoral Fellow, Department of Experimental Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA
  • 2014–2016, Postdoctoral Fellow, Viral Pathogenesis and Vaccine Development Group, VIDO-InterVac, University of Saskatchewan, SK, Canada

Degrees

  • 2014, Ph.D., Veterinary Microbiology, University of Saskatchewan, SK, Canada
  • 1994, B.S.Ag. Animal Science, University of Saskatchewan, SK, Canada,
  • Mackenzie-Dyck, S., Kovacs-Nolan, J., Latimer, L., Atanley, E., Babiuk, L.A., van Drunen Littel-van den Hurk, S. (2014) Immunogenicity of a bovine herpesvirus-1 glycoprotein D DNA vaccine complexed with bovine neutrophil beta-defensin 3. Clin Vaccine Immunol  22, 79-90.
  • Mackenzie-Dyck, S., Kovacs-Nolan, J., Snider, M., Babiuk, L.A., van Drunen Littel-van den Hurk, S. (2014) Inclusion of the bovine neutrophil beta-defensin 3 with glycoprotein D of Bovine herpesvirus-1 in a DNA vaccine modulates immune responses of mice and cattle. Clin Vaccine Immunol 21, 463-477.
  • Mackenzie-Dyck, S., Attah-Poku, S., Juillard, V., Babiuk, L.A., van Drunen Littel-van den Hurk, S. (2011) The synthetic peptides bovine enteric beta-defensin (EBD), bovine neutrophil beta-defensin (BNBD) 9 and BNBD 3 are chemotactic for immature bovine dendritic cells. Vet Immunol Immunopathol 143, 87-107.
  • Facci, M.R., Auray, G., Buchanan, R., van Kessel, J., Thompson, D.R., Mackenzie-Dyck, S., Babiuk, L.A., Gerdts, V. (2010) A comparison between isolated blood dendritic cells and monocyte-derived dendritic cells in pigs. Immunology 129, 396-405.
  • 1994, Robinson Scholarship in Animal Science from the Department of Animal and Poultry Science, in the College of Agriculture at the University of Saskatchewan
  • 1993, Alan J. Hosegood Pioneer Farmer Award in Agriculture for scholastic achievement by the College of Agriculture at the University of Saskatchewan.
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