An NCI-designated Comprehensive Cancer Center

Leo David Wang, M.D., Ph.D.

Pediatric Hematologist - Oncologist
Research Focus
  • Benign and malignant hematopoietic stem cells
Appointments
Assistant Professor, Department of Immuno-Oncology; Assistant Professor, Department of Pediatrics

One of the most important pieces of advice that families should hear is that children and young adults with cancer need to be treated at pediatric cancer centers. There are overwhelmingly convincing data showing that outcomes are much better when young patients are treated by pediatric oncologists."

Dr. Wang earned his undergraduate degree in molecular biophysics and biochemistry from Yale University, followed by his Ph.D. and medical doctorate at University of Chicago. He successfully completed an internship and residency in pediatrics at Children’s Hospital of Philadelphia. Dr. Wang then completed his pediatric hematology/oncology/stem cell transplantation fellowship at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, and pursued postdoctoral research in the laboratory of Amy Wagers, Ph.D.,  at the Joslin Diabetes Center and Harvard Stem Cell Institute.

Board-certified in pediatrics and pediatric hematology/oncology, Dr. Wang is the recipient of multiple honors and awards, including a Damon-Runyon Foundation Cancer Research Fellowship, a St. Baldrick’s Scholar Award and an Alex’s Lemonade Stand Foundation Young Investigator Award.

Dr. Wang will attend on the pediatric oncology and stem cell transplant services while maintaining an active research laboratory. His research focuses on utilizing novel mass spectrometry-based phosphoproteomic techniques to identify targetable activation pathways in small numbers of rare cells. He plans to continue this work on benign and malignant hematopoietic stem cells, as well as to extend his research to investigate critical pathways important in the immune response to cancer. Ultimately, he plans to create a research program that bridges clinical oncology and bone marrow transplantation with fundamental mechanistic research, permitting the translation of novel laboratory findings into clinically important interventions.

Locations

City of Hope Comprehensive Cancer Center, 1500 East Duarte Road

Duarte, CA 91010

Rao TN, Gupta MK, Softic S, Wang LD, Jang YC, Thomou T, Bezy O, Kulkarni RN, Kahn CR, Wagers AJ. Attenuation of PKCδ enhances metabolic activity and promotes expansion of blood progenitors. The EMBO Journal 2018; 37 (24). PMID: 30446598, PMCID: PMC6293338
 
Pawlowska AB, Cheng JC, Karras NA, Sun W, Wang LD, Bell AD, Gutierrez L, Rosenthal J. HLA Haploidentical Stem Cell Transplant with Pretransplant Immunosuppression for Patients with Sickle Cell Disease. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation 2018; 24 (1): 185-189. PMID: 28939451
 
Wang LD, Ficarro SB, Hutchinson JN, Csepanyi-Komi R, Nguyen PT, Wisniewski E, Sullivan J, Hofmann O, Ligeti E, Marto JA, Wagers AJ. Phosphoproteomic profiling of mouse primary HSPCs reveals new regulators of HSPC mobilization. Blood 2016; 128 (11): 1465-74. PMID: 27365422, PMCID: PMC5025898
 
Rowe RG, Wang LD, Coma S, Han A, Mathieu R, Pearson DS, Ross S, Sousa P, Nguyen PT, Rodriguez A, Wagers AJ, Daley GQ. Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis. The Journal of Experimental Medicine 2016; 213 (8): 1497-512. PMID: 27401346, PMCID: PMC4986532
 
Wang LD, Rao TN, Rowe RG, Nguyen PT, Sullivan JL, Pearson DS, Doulatov S, Wu L, Lindsley RC, Zhu H, DeAngelo DJ, Daley GQ, Wagers AJ. The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy. Leukemia 2015; 29 (6): 1320-30. NIHMSID: NIHMS662665, PMID: 25655194, PMCID: PMC4456252
 
Nabors LK, Wang LD, Wagers AJ, Kansas GS. Overlapping roles for endothelial selectins in murine hematopoietic stem/progenitor cell homing to bone marrow. Experimental Hematology 2013; 41 (7): 588-96. NIHMSID: NIHMS475023, PMID: 23499761, PMCID: PMC3700604
 
Wang LD, Wagers AJ. Dynamic niches in the origination and differentiation of haematopoietic stem cells. Nature reviews. Molecular Cell Biology 2011; 12 (10): 643-55. NIHMSID: NIHMS571834, PMID: 21886187, PMCID: PMC4040463
 
Clark MR, Cooper AB, Wang LD, Aifantis I. The pre-B cell receptor in B cell development: recent advances, persistent questions and conserved mechanisms. Current Topics in Microbiology and Immunology 2005; 290: 87-103. PMID: 16480040
 
Wang LD, Lopes J, Cooper AB, Dang-Lawson M, Matsuuchi L, Clark MR. Selection of B lymphocytes in the periphery is determined by the functional capacity of the B cell antigen receptor. Proceedings of the National Academy of Sciences of the United States of America 2004; 101 (4): 1027-32. PMID: 14722356, PMCID: PMC327145
 
Wang LD, Clark MR. B-cell antigen-receptor signaling in lymphocyte development. Immunology 2003; 110 (4): 411-20.PMID: 14632637, PMCID: PMC1783068
 
Wang LD, Clark MR. Igalpha: B all that you can B. The Journal of Clinical Investigation 1999; 104 (8): 1011-2. PMID: 10525036, PMCID: PMC408873
 
Atwood WJ, Wang L, Durham LC, Amemiya K, Traub RG, Major EO. Evaluation of the role of cytokine activation in the multiplication of JC virus (JCV) in human fetal glial cells. Journal of Neurovirology 1995; 1 (1): 40-9. PMID: 9222341
 
Gelbard HA, Nottet HS, Swindells S, Jett M, Dzenko KA, Genis P, White R, Wang L, Choi YB, Zhang D. Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin. Journal of Virology 1994; 68 (7): 4628-35. PMID: 8207837, PMCID: PMC236390
 
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