Lu Yang

Lu Yang, Ph.D.

  • Assistant Research Professor, Department of Systems Biology

Lu Yang, Ph.D.

Research Focus :
  • High-density CRISPR scanning to further dissect functional protein domain or novel domain
  • Integrating systems biology, clinical science, sequencing techniques and bioinformatics to improve cancer research, diagnosis and treatment
Lu Yang received her doctoral degree in Pharmacology from University of Louisville, Kentucky in 2010. Her research interest was initially focused on characterizing changes of renal cell gene expression and to identify potential molecular pathways involved in the development of Diabetic Nephropathy, using the OVE26 diabetic mouse model. After additional postdoctoral training in diagnostic informatics before she joined the Functional Genomics Core of the Beckman Research Institute as a staff scientist in 2012. In the core, she provided leadership role in developing in house single cell RNA-seq data analyzing algorithm and published a first-author bioinformatics paper. She was also actively involved in multiple other research projects and was listed as co-author in several high-impact papers.
 
Dr. Lu Yang joined the Department of System Biology in 2017 as a Research Assistant Professor. Her long-term goal in the Department of System Biology is to integrate basic biology, clinical science, sequencing technology and bioinformatics to improve research in leukemia and lymphoma, diagnostics and drug-discovery. Her recent research interest focuses on search for the potential domain of sgRNA placement which related to maximum phenotype, by interrogating the output of high-density CRISPR screening data.
  • 2017-present, Assistant Research Professor, Department of Systems Biology, City of Hope Beckman Research Institute, Monrovia, CA
  • 2012–2017, Staff Scientist, Integrative Genomics Core, City of Hope National Medical Center, Duarte, CA
  • 2011–2012, Postdoctoral Fellow, Department of Pathology and Laboratory Sciences, University of Louisville, Louisville, KY
  • 2010, Intern, Pharmacokinetics and Drug Metabolism Intern, Amgen Inc., Cambridge, MA

Degrees

  • 2010, Ph.D., Pharmacology & Toxicology, University of Louisville, Louisville, KY
  • 2007, M.S., Pharmacology & Toxicology, University of Louisville, Louisville, KY
  • 2004, B.S., Biology, University of Science and Technology of China, Hefei, China,
  • Petrossian K, Kanaya N, Lo C, Hsu PY, Nguyen D, Yang L, Yang L, Warden C, Wu X, Pillai R, Bernal L, Huang CS, Kruper L, Yuan Y, Somlo G, Mortimer J, Chen S. ERα-mediated cell cycle progression is an important requisite for CDK4/6 inhibitor response in HR+ breast cancer. Oncotarget. 2018; 9:27736-27751
  • Sen S, He Z, Ghosh S, Dery KJ, Yang L, Zhang J, Sun Z. PRMT1 Plays a Critical Role in Th17 Differentiation by regulating reciprocal recruitment of STAT3 and STAT5. J Immunol. 2018, pii: ji1701654. doi: 10.4049/jimmunol.1701654.
  • Yun X, Zhang K, Wang J, Pangeni RP, Yang L, Bonner M, Wu J, Wang J, Nardi IK, Gao M, Raz DJ. Targeting USP22 suppresses tumorigenicity and enhances cisplatin sensitivity through ALDH1A3 downregulation in cancer-initiating cells from lung adenocarcinoma. Mol Cancer Res. 2018, doi: 10.1158/1541-7786.MCR-18-0042.
  • Dery KJ, Silver C, Yang L, Shively JE. Interferon regulatory factor 1 and a variant of heterogeneous nuclear ribonucleoprotein L coordinately silence the gene for adhesion protein CEACAM1. J Biol Chem. 2018; 293:9277-9291.
  • Li S, Ali S, Duan X, Liu S, Du J, Liu C, Dai H, Zhou M, Zhou L, Yang L, Chu P, Li L, Bhatia R, Schones DE, Wu X, Xu H, Hua Y, Guo Z, Yang Y, Zheng L, Shen B. JMJD1B Demethylates H4R3me2s and H3K9me2 to facilitate gene expression for development of hematopoietic stem and progenitor cells. Cell Rep. 2018; 23:389-403.
  • Wang X, Walter M, Urak R, Weng L, Huynh C, Lim L, Wong CW, Chang WC, Thomas SH, Sanchez JF, Yang L, Brown CE, Pichiorri F, Htut M, Krishnan AY, Forman SJ. Lenalidomide enhances the function of CS1 chimeric antigen receptor redirected T cells against multiple myeloma. Clin Cancer Res. 2018; 24:106-119
  • Yang L, Liu JC, Lu Q, Riggs A, X Wu. SAIC: An iterative clustering approach for analysis of single cell RNA-seq data.  BMC Genomics. 2017; 18:689.
  • Gu Y, Zhang J, Ma X, Kim BW, Wang H, Li J, Pan Y, Xu Y, Ding L, Yang L, Guo C, Wu X, Wu J, Wu K, Gan X, Li G, Li L, Forman SJ, Chan WC, Xu R, Huang W. Stabilization of the c-Myc protein by CAMKIIγ promotes T-cell lymphoma. Cancer Cell 2017; 32: 115-128.
  • Chang J, Mancuso MR, Maier C, Liang X, Yuki K, Yang L, Kwong JW, Wang J, Rao V, Vallon M, Kosinski C, Zhang JJ, Mah AT, Xu L, Li L, Gholamin S, Reyes TF, Li R, Kuhnert F, Han X, Yuan J, Chiou SH, Brettman AD, Daly L, Corney DC, Cheshier SH, Shortliffe LD, Wu X, Snyder M, Chan P, Giffard RG, Chang HY, Andreasson K, Kuo CJ. Gpr124 is essential for blood-brain barrier intergrity in central nervous system disease. Nat Med. 2017; 23: 450-460.
  • Zhang K, Wu X, Wang J, Lopez J. Zhou W, Yang L, Wang SE, Raz DJ, Kim JY. Circulating miRNA profile in esophageal adenocarcinoma. Am J Cancer Res. 2016; 6:2713-2721.
  • Zhou L, Dai H, Wu J, Zhou M, Yuan H, Du J, Yang L, Wu X, Xu H, Hua Y, Xu J, Zheng L, Shen B. Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development. FASEB J. 2017; 31:132-147.
  • Li Z, Oganesyan D, Mooney R, Rong X, Christensen MJ, Shahmanyan D, Perrigue PM, Benetatos J, Tsaturyan L, Aramburo S, Annala AJ, Yang L, Najbauer J, Wu X, Barish ME, Brody DL, Aboody KS, Gutova M.  L-MYC expression maintains self-renewal and prolongs multipotency of primary human neural stem cells. Stem Cell Reports 2016; 7:483-7495.
  • Cui Q, Yang S, Ye P, Tian E, Sun G, Zhou J, Sun G, Liu X, Chen C, Murai K, Zhao C, Azizian KT, Yang L, Warden C, Wu X, D'Apuzzo M, Brown C, Badie B, Peng L, Riggs AD, Rossi JJ, Shi Y.  Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis. Nat Commun. 2016; 7:10637.
  • Jin SG, Xiong W, Wu X, Yang L, Pfeifer G.  The DNA methylation landscape of human melanoma. Genomics. 2015; 106:322-330.
  • Wang J, Zhang K, Wang J, Wu X, Liu X, Li B, Zhu Y, Yu Y, Cheng Q, Hu Z, Guo C, Hu S, Mu B, Tsai CH, Li J, Smith L, Yang L, Liu Q, Chu P, Chang V, Zhang B, Wu M, Jiang X, Yen Y.  Underexpression of LKB1tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma. Oncotarget. 2015; 6:18905-18920.
  • Wang C, Gong B, Bushel PR, Thierry-Mieg J, Thierry-Mieg D, Xu J, Fang H, Hong H, Shen J, Su Z, Meehan J, Li X, Yang L, Li H, Łabaj PP, Kreil DP, Megherbi D, Gaj S, Caiment F, van Delft J, Kleinjans J, Scherer A, Devanarayan V, Wang J, Yang Y, Qian HR, Lancashire LJ, Bessarabova M, Nikolsky Y, Furlanello C, Chierici M, Albanese D, Jurman G, Riccadonna S, Filosi M, Visintainer R, Zhang KK, Li J, Hsieh JH, Svoboda DL, Fuscoe JC, Deng Y, Shi L, Paules RS, Auerbach SS, Tong W. The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance. Nat Biotechnol. 2014; 32:926-932.
  • Yang L, Valdes R Jr, Taubert D, Linder MW. A diagnostic informatics approach for stratifying risk outcome based on combined genotype effects. Ther Drug Monit. 2012; 34:283-288.
  • Yang L, Brozovic S, Long YS, Kralik PM, Waigel S, Zacharias W, Zheng S, Epstein PN. Inflammatory gene expression in OVE26 diabetic kidney during the development of nephropathy. Nephron Exp Nephrol. 2011; 119:e8-e20.
  • Zheng S, Huang Y, Yang L, Chen T, Xu J, Epstein PN. Uninephrectomy of diabetic OVE26 mice greatly accelerates albuminuria, fibrosis, inflammatory cell infiltration and changes in gene expression. Nephron Exp Nephrol. 2011; 119:e21-e23.
  • Kralik PM, Long Y, Song Y, Yang L, Wei H, Coventry S, Zheng S, Epstein PN. Diabetic albuminuria is due to a small fraction of nephrons distinguished by albumin-stained tubules and glomerular adhesions. Am J Pathol. 2009; 175:500-509.
  • Yang L, Zheng S, Epstein PN. Metallothionein over-expression in podocytes reduces adriamycin nephrotoxicities. Free Radic Res. 2009; 43:174-182.
  • Zheng S, Carlson EC, Yang L, Kralik PM, Huang Y, Epstein PN. Podocyte-specific overexpression of the antioxidant metallothionein reduces diabetic nephropathy. J Am Soc Nephrol. 2008; 19:2077-2085.
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