Experimental Therapeutics - Peng Ye

Peng Ye, M.D.

  • Research Associate II, Department of Experimental Therapeutics

Peng Ye, M.D.

Expertise

  • Molecular biology related techniques (PCR, Western blot, plasmid propagation and purification, etc)
  • Immunology techniques, immuno-histochemistry staining
  • Tissue and cell culture
  • Histological techniques (frozen tissue block sectioning, H& E staining, etc)
  • Animal care (mouse related work)
  • 2008-present, Research Associate II, Beckman Research Institure, City of Hope National Medical Center, Duarte, CA
  • 2005-2006, Research Associate, Department of Medicine, University of Southern California, Los Angeles, CA
  • 2003-2005, Assistant Professor of Research Medicine, Department of Medicine, University of Southern California, Los Angeles, CA
  • 2001-2003, Nephrology Research Fellow, University of Texas Health Science Center, San Antonio, TX
  • 1998-2001, Research Associate, Gene Therapy Program, Section of Pulmonary/Critical Care, Louisiana State University Health Sciences Center, New Orleans, LA
  • 1996-1998, Postdoctoral Research Fellow, Louisiana State University Medical Center, New Orleans, LA
  • 1989, Fudan University, China, Master in Medicine (M.M.)
  • 1984, Fujian Medical College, China, M.D.
  • Murai K, Sun Q, Ye P, Tian E, Yang S, Cui Q, Sun G, Trinh D, Sun O, Hong T, Wen Z, Kalkum M, Riggs A, Song H, Ming G, Shi Y (2016). The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model" Nature Communication accepted Feb 2016.
  • Cui Q, * Yang S, * Ye P, Tian E, Sun G, Zhou J, Sun G, Liu X, Chen C, Murai K, Zhao C, Azizian KT, Yang L, Warden C, Wu X, D’Apuzzo M, Brown C, Badie B, Peng L, Riggs A, Rossi JJ, Shi Y (2016). Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis. Nature Communication accepted Jan 2016.
  • Murai K, Qu Q, Sun G, Ye P (Co first author), Li W, Asuelime G, Sun E, Tsai GE, Shi Y (2014). Nuclear receptor TLX stimulates hippocampal neurogenesis and enhances learning and memory in a transgenic mouse model. Proc Natl Acad Sci U S A 111(25): 9115-9120.
  • Zhang RR, Cui QY, Murai K, Lim YC, Smith ZD, Jin S, Ye P, Rosa L, Lee YK, Wu HP, Liu W, Xu ZM, Yang L, Ding YQ, Tang F, Meissner A, Ding C, Shi Y, Xu GL (2013). Tet1 regulates adult hippocampal neurogenesis and cognition. Cell Stem Cell 13(2): 237-245.
  • Zhao C, Sun G, Ye P, Li S, Shi Y (2013). MicroRNA let-7d regulates the TLX/microRNA-9 cascade to control neural cell fate and neurogenesis. Sci Rep 3: 1329.
  • Qu Q, Sun G, Murai K, Ye P, Li W, Asuelime G, Cheung YT, Shi Y (2013). Wnt7a regulates multiple steps of neurogenesis. Mol Cell Biol 33(13): 2551-2559.
  • Li S, Sun G, Murai K, Ye P, Shi Y (2012). Characterization of TLX expression in neural stem cells and progenitor cells in adult brains. PLoS One 7(8): e43324.
  • Li W, Tian E, Chen ZX, Sun G, Ye P, Yang S, Lu D, Xie J, Ho TV, Tsark WM, Wang C, Horne DA, Riggs AD, Yip ML, Shi Y (2012). Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A 109(51): 20853-20858.
  • Sun G, Ye P, Murai K, Lang MF, Li S, Zhang H, Li W, Fu C, Yin J, Wang A, Ma X, Shi Y (2011). miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells. Nat Commun 2: 529.
  • Sun G, Alzayady K, Stewart R, Ye P, Yang S, Li W, Shi Y (2010). Histone demethylase LSD1 regulates neural stem cell proliferation. Mol Cell Biol 30(8): 1997-2005.
  • Qu Q, Sun G, Li W, Yang S, Ye P, Zhao C, Yu RT, Gage FH, Evans M, Shi Y (2010). Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal. Nat Cell Biol 12(1): 31-40; sup pp 31-39.
  • Ye P, Habib SL, Ricono JM, Kim NH, Choudhury GG, Barnes JL, Abboud HE, Arar MY (2004). Fibronectin induces ureteric bud cells branching and cellular cord and tubule formation. Kidney International. 66(4):1356-64.
  • Zheng M, Shellito JE, Marrero L, Zhong Q, Stewart J, Ye P, Wallace V, Schwarzenberger P, Kolls JK (2001). CD4+ T cell–independent vaccination against pneumocystis carinii in mice. J Clin Invest 108:1469–1674.
  • Ye P, Rodriquez FH, Peschon JJ, Shellito JE, Nelson S, Kolls JK (2001). Increased susceptibility of Il-17 receptor knockout mice to Klebsiella pneumoniae infection. J Exp Med 194:4, 519–527.
  • Ye P, Garvey PB, Huang W, Gogd DE, Zhang Z, Schwarzenberger P, Summer WR, Shellito JE, Nelson S, Kolls JK (2001). IL-17 increases lung immunity and help lung host defense against K. pneumoniae infection. Am J Respir Cell Mol Biol 25:335–340, 2001.
  • Zhang Z, Cork J, Ye P, Lei D, Schwarzenberger PO, Summer WR, Shellito JE, Nelson S, Kolls JK (2000). Inhibition of TNF-alpha processing and TACE-mediated ectodomain shedding by ethanol. J Leukoc Biol 67:856–862.
  • Schwarzenberger P, Huang W, Ye P, Oliver P, Manuel M, Zhang Z, Bagby GJ, Nelson S, Kolls JK (2000). Requirement of endogenous stem cell factor and granulocyte-colony-stimulating factor for IL-17-mediated granulopoiesis. J Immunol 164:4783–4789.
  • Kolls JK, Habetz S, Shean MK, Vazquez C, Brown JA, Lei D, Schwarzenberger P, Ye P, Nelson S, Summer WR, Shellito JE (1999). IFN-gamma and CD8+ T cells restore host defenses against pneumocystis carinii in mice depleted of CD4+ T–cells. J Immunol 162:2890–2894.
  • Schwarzenberger P, La Russa V, Miller A, Ye P, Huang W, Zieske A, Nelson S, Bagby GJ, Stoltz D, Mynatt RL, Spriggs M, Kolls JK (1998). IL-17 stimulates granulopoiesis in mice: Use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines. J Immunol 1;161:6383–6389.
  • Schwarzenberger P, Lei D, Freeman SM, Ye P, Weinacker A, Theodossiou C, Summer W, Kolls JK (1998). Antitumor activity with the HSV-tk-gene-modified cell line PA-1-STK in malignant mesothelioma. Am J Respir Cell Mol Biol 19:333–337.
  • Schwarzenberger P, Harrison L, Weinacker A, Gaumer R, Theodossiou C, Summer W, Ye P, Marrogi AJ, Ramesh R, Freeman S, Kolls JK (1998). Gene therapy for malignant mesothelioma: A novel approach for an incurable cancer with increased incidence in Louisiana. J La State Med Soc 150:168–174.
  • Kolls JK, Lei D, Stoltz D, Zhang P, Schwarzenberger PO, Ye P, Bagby GJ, Summer WR, Shellito JE, Nelson S (1998). Adenoviral-mediated interferon-gamma gene therapy augments pulmonary host defense of ethanol-treated rats. Alcohol Clin Exp Res 22:157–162.
  • Ji W, Qu GZ, Ye P, Zhang XY, Halabi S, Ehrlich M (1995). Frequent detection of Bcl-2/JH translocation in human blood and organ samples by a quantitative polymerase chain reaction assay. Cancer Res 55:2876–2882.
  • Ye P, et al (1993). The lipid metabolism in kidney diseases. Journal of Fujian Medical College 6:22.
  • Ye P, et al (1991). The bicarbonate, TA and ammonia values in 131 healthy children. Clinical Journal of Pediatrics 8:13.
  • Ye P, et al (1991). Bicarbonate and neutral phosphate loading tests for assessment of the distal renal tubular acidosis. Chinese Journal of Nephrology 4:20.
  • 2000, Third place winner, Southern Society of Clinical Investigation Young Investigator Award, Increased susceptibility of IL-7 receptor knockout mice in lung K. pneumoniae infection
  • 1999, First place winner, Southern Society of Clinical Investigation Young Investigator Award, IL-17 improves lung host defense against K. pneumoniae infection
  • 1198, Third place winner, Southern Society of Clinical Investigation Young Investigator Award, Cell-based gene therapy for malignant mesothelioma
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