Yuan Yuan, M.D., Ph.D.

Yuan Yuan, M.D., Ph.D. is an Associate Professor specializing in breast oncology in the Department of Medical Oncology & Therapeutics.

Prior to joining City of Hope in 2012, she was an assistant professor at Loma Linda University Medical Center in the Division of Medical Oncology and Hematology, and a principal investigator for multiple breast cancer trials. Dr. Yuan received her bachelor of medicine degree from Xuzhou Medical College in Xuzhou, China, and an M.S. in oncology from Peking Union Medical College in Beijing, China. She went on to complete a Ph.D. in biochemistry and molecular biology from the University of California, Riverside. She then completed a research fellowship at the Scripps Research Institute in La Jolla, CA, followed by an internship and residency in internal medicine at the New York University Downtown Hospital in New York, NY. She furthered her training with a hematology and oncology fellowship at the New York University Medical Center, under the direction of Dr. Franco Muggia.

Dr. Yuan’s clinical research interests center on novel therapeutics for metastatic triple negative breast cancer (TNBC). She currently leads multiple clinical trials for metastatic triple negative breast cancer including the following targeted therapies: immune check point inhibitors, androgen receptor targeted therapy, PIK3CA pathway inhibition. She is awarded a STOP CANCER Career Development Award supporting translational research in TNBC tumor evolution and a NIH R03 grant studying biomarkers predicting chemotherapy toxicity in women with breast cancer undergoing chemotherapy. She is experienced in pre-clinical, translational, and clinical application of novel combination therapies. She has worked closely with City of Hope’s translational scientist, molecular pathology core, genomics, bioinformatics and biostatistics core to study the longitudinal genomic mutation profiling of paired metastatic breast cancer. She serves as principle investigator for multiple investigator-initiated trials including a phase II trial combining letrozole, palbociclib and pembrolizumab in patients with HR+ metastatic BC (NCT02778685); a phase I/IB clinical trial studying eribulin plus everolimus in patients with metastatic TNBC (NCT02120469); a phase II trial androgen receptor (AR) targeted therapy GTx-024 in combination with pembrolizumab in patients with metastatic AR+ TNBC; a phase IB study combining ipatasertib with carboplatin or carboplatin/paclitaxel in patients with metastatic TNBC. Her clinical trial work in AR+ TNBC was awarded Phase I Foundation Grant in correlative studies.

Dr. Yuan has multiple publications in peer-reviewed literature and has been invited to present at national and international meetings. She is board certified in internal medicine, hematology and oncology.