City of Hope investigates a novel therapeutic approach in AML

April 26, 2019 | by City of Hope

 
8-chloro-adenosine, an RNA-directed nucleoside analog, may prove a promising target with a unique mechanism of action for patients with relapsed or refractory acute myeloid leukemia (AML).
 
Previous activity has been demonstrated in a number of solid tumors and hematological malignancies, and now principal investigator Vinod Pullarkat, M.D., from City of Hope is opening the first-in-man investigation of the new therapeutic approach in poor-risk AML.
 
Unlike other nucleoside analogs used to treat AML, 8-chloro-adenosine inhibits RNA synthesis within AML cells in a dose-dependent manner. The unique RNA and ATP-targeting mechanism of action will first be evaluated in single-agent studies, with the potential for synergistic effects with Bcl-2 inhibitors in future research.
 
The phase I/II dose-finding study evaluating 8-chloro-adenosine as a single agent is now open for recruitment for patients who have:
  • Relapsed AML after failure on at least one line of salvage therapy
  • De novo AML and have not achieved complete remission after two lines of therapy
  • AML evolving from myelodysplastic syndrome or myeloproliferative disorder and have failed a hypomethylating agent or induction chemotherapy
  • Relapsed after allogeneic hematopoietic cell transplant

8-Chloro-Adenosine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia (NCT02509546)

For enrollment information in this study, please contact Vinod Pullarkat, M.D., by phone at 626-256-4673.
 
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