Recent Publications

  1. Al-Abdullah, I.H., Bagramyan, K., Bilbao, S., Qi, M., and Kalkum, M. Fluorogenic Peptide Substrate for Quantification of Bacterial Enzyme Activities. Scientific Reports 7, 2017. https://dx.doi.org/10.1038/srep44321
     
  2. Ashing, K.T., Cho, D., Lai, L., Yeung, S., Young, L., Yeon, C., and Fong, Y. Exploring Characteristics, Predictors, and Consequences of Fear of Cancer Recurrence among Asian-American Breast Cancer Survivors. Psycho-Oncology, 2017. https://dx.doi.org/10.1002/pon.4350
     
  3. Bhargava, R., Carson, C.R., Lee, G., and Stark, J.M. Contribution of Canonical Nonhomologous End Joining to Chromosomal Rearrangements Is Enhanced by Atm Kinase Deficiency. Proceedings of the National Academy of Sciences of the United States of America 114:728-33, 2017. https://dx.doi.org/10.1073/pnas.1612204114
     
  4. Bouska, A., Zhang, W., Gong, Q., Iqbal, J., Scuto, A., Vose, J., Ludvigsen, M., Fu, K., Weisenburger, D.D., Greiner, T.C., Gascoyne, R.D., Rosenwald, A., Ott, G., Campo, E., Rimsza, L.M., Delabie, J., Jaffe, E.S., Braziel, R.M., Connors, J.M., Wu, C.I., Staudt, L.M., D'Amore, F., McKeithan, T.W., and Chan, W.C. Combined Copy Number and Mutation Analysis Identifies Oncogenic Pathways Associated with Transformation of Follicular Lymphoma. Leukemia 31:83-91, 2017. https://dx.doi.org/10.1038/leu.2016.175
     
  5. Chan, L.N., Chen, Z., Braas, D., Lee, J.W., Xiao, G., Geng, H., Cosgun, K.N., Hurtz, C., Shojaee, S., Cazzaniga, V., Schjerven, H., Ernst, T., Hochhaus, A., Kornblau, S.M., Konopleva, M., Pufall, M.A., Cazzaniga, G., Liu, G.J., Milne, T.A., Koeffler, H.P., Ross, T.S., Sanchez-Garcia, I., Borkhardt, A., Yamamoto, K.R., Dickins, R.A., Graeber, T.G., and Muschen, M. Metabolic Gatekeeper Function of B-Lymphoid Transcription Factors. Nature 542:479-83, 2017. https://dx.doi.org/10.1038/nature21076
     
  6. Chiuppesi, F., Kaltcheva, T., Meng, Z., Barry, P.A., Diamond, D.J., and Wussow, F. Identification of a Continuous Neutralizing Epitope within Ul128 of Human Cytomegalovirus. Journal of Virology 91, 2017. https://dx.doi.org/10.1128/JVI.01857-16
     
  7. Chu, F.F., Esworthy, R.S., Doroshow, J.H., Grasberger, H., Donko, A., Leto, T.L., Gao, Q., and Shen, B. Deficiency in Duox2 Activity Alleviates Ileitis in Gpx1- and Gpx2-Knockout Mice without Affecting Apoptosis Incidence in the Crypt Epithelium. Redox Biol 11:144-56, 2017. https://dx.doi.org/10.1016/j.redox.2016.11.001
     
  8. Cui, Q., Shi, H., Ye, P., Li, L., Qu, Q., Sun, G., Sun, G., Lu, Z., Huang, Y., Yang, C.G., Riggs, A.D., He, C., and Shi, Y. M6a Rna Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells. Cell Rep 18:2622-34, 2017. https://dx.doi.org/10.1016/j.celrep.2017.02.059
     
  9. Dura-Ferrandis, E., Mandelblatt, J.S., Clapp, J., Luta, G., Faul, L., Kimmick, G., Cohen, H.J., Yung, R.L., and Hurria, A. Personality, Coping, and Social Support as Predictors of Long-Term Quality-of-Life Trajectories in Older Breast Cancer Survivors: Calgb Protocol 369901 (Alliance). Psycho-Oncology, 2017. https://dx.doi.org/10.1002/pon.4404
     
  10. Freedman, R.A., Foster, J.C., Seisler, D.K., Lafky, J.M., Muss, H.B., Cohen, H.J., Mandelblatt, J., Winer, E.P., Hudis, C.A., Partridge, A.H., Carey, L.A., Cirrincione, C., Moreno-Aspitia, A., Kimmick, G., Jatoi, A., and Hurria, A. Accrual of Older Patients with Breast Cancer to Alliance Systemic Therapy Trials over Time: Protocol A151527. Journal of Clinical Oncology 35:421-31, 2017. https://dx.doi.org/10.1200/JCO.2016.69.4182
     
  11. Gogoshin, G., Boerwinkle, E., and Rodin, A.S. New Algorithm and Software (Bnomics) for Inferring and Visualizing Bayesian Networks from Heterogeneous Big Biological and Genetic Data. Journal of Computational Biology 24:340-56, 2017. https://dx.doi.org/10.1089/cmb.2016.0100
     
  12. Gong, J., Cho, M., Sy, M., Salgia, R., and Fakih, M. Molecular Profiling of Metastatic Colorectal Tumors Using Next-Generation Sequencing: A Single-Institution Experience. Oncotarget, 2017. https://dx.doi.org/10.18632/oncotarget.15030
     
  13. Gong, J., Wang, C., Lee, P.P., Chu, P., and Fakih, M. Response to Pd-1 Blockade in Microsatellite Stable Metastatic Colorectal Cancer Harboring a Pole Mutation. Journal of the National Comprehensive Cancer Network 15:142-47, 2017. https://www.ncbi.nlm.nih.gov/pubmed/?term=28188185
     
  14. Gutova, M., Goldstein, L., Metz, M., Hovsepyan, A., Tsurkan, L.G., Tirughana, R., Tsaturyan, L., Annala, A.J., Synold, T.W., Wan, Z., Seeger, R., Anderson, C., Moats, R.A., Potter, P.M., and Aboody, K.S. Optimization of a Neural Stem-Cell-Mediated Carboxylesterase/Irinotecan Gene Therapy for Metastatic Neuroblastoma. Mol Ther Oncolytics 4:67-76, 2017. https://dx.doi.org/10.1016/j.omto.2016.11.004
     
  15. Han, D., Chen, Q., Shi, J., Zhang, F., and Yu, X. Ctcf Participates in DNA Damage Response Via Poly(Adp-Ribosyl)Ation. Sci Rep 7:43530, 2017. https://dx.doi.org/10.1038/srep43530
     
  16. Jandial, R., Choy, C., Levy, D.M., Chen, M.Y., and Ansari, K.I. Astrocyte-Induced Reelin Expression Drives Proliferation of Her2+ Breast Cancer Metastases. Clinical & Experimental Metastasis 34:185-96, 2017. https://dx.doi.org/10.1007/s10585-017-9839-9
     
  17. Jaramillo, R., Shuck, S.C., Chan, Y.S., Liu, X., Bates, S.E., Lim, P.P., Tamae, D., Lacoste, S., O'Connor, T.R., and Termini, J. DNA Advanced Glycation End Products (DNA-Ages) Are Elevated in Urine and Tissue in an Animal Model of Type 2 Diabetes. Chemical Research in Toxicology 30:689-98, 2017. https://dx.doi.org/10.1021/acs.chemrestox.6b00414
     
  18. Kantarjian, H., Stein, A., Gokbuget, N., Fielding, A.K., Schuh, A.C., Ribera, J.M., Wei, A., Dombret, H., Foa, R., Bassan, R., Arslan, O., Sanz, M.A., Bergeron, J., Demirkan, F., Lech-Maranda, E., Rambaldi, A., Thomas, X., Horst, H.A., Bruggemann, M., Klapper, W., Wood, B.L., Fleishman, A., Nagorsen, D., Holland, C., Zimmerman, Z., and Topp, M.S. Blinatumomab Versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia. N Engl J Med 376:836-47, 2017. https://dx.doi.org/10.1056/NEJMoa1609783
     
  19. Keu, K.V., Witney, T.H., Yaghoubi, S., Rosenberg, J., Kurien, A., Magnusson, R., Williams, J., Habte, F., Wagner, J.R., Forman, S., Brown, C., Allen-Auerbach, M., Czernin, J., Tang, W., Jensen, M.C., Badie, B., and Gambhir, S.S. Reporter Gene Imaging of Targeted T Cell Immunotherapy in Recurrent Glioma. Sci Transl Med 9, 2017. https://dx.doi.org/10.1126/scitranslmed.aag2196
     
  20. Kracht, M.J., van Lummel, M., Nikolic, T., Joosten, A.M., Laban, S., van der Slik, A.R., van Veelen, P.A., Carlotti, F., de Koning, E.J., Hoeben, R.C., Zaldumbide, A., and Roep, B.O. Autoimmunity against a Defective Ribosomal Insulin Gene Product in Type 1 Diabetes. Nature Medicine 23:501-07, 2017. https://dx.doi.org/10.1038/nm.4289
     
  21. Krishnan, A.Y., Palmer, J., Nademanee, A.P., Chen, R., Popplewell, L.L., Tsai, N.C., Sanchez, J.F., Simpson, J., Spielberger, R., Yamauchi, D., and Forman, S.J. Phase Ii Study of Yttrium-90 Ibritumomab Tiuxetan Plus High-Dose Bcnu, Etoposide, Cytarabine, and Melphalan for Non-Hodgkin Lymphoma: The Role of Histology. Biology of Blood and Marrow Transplantation, 2017. https://dx.doi.org/10.1016/j.bbmt.2017.03.004
     
  22. La Rosa, C., Longmate, J., Martinez, J., Zhou, Q., Kaltcheva, T.I., Tsai, W., Drake, J., Carroll, M., Wussow, F., Chiuppesi, F., Hardwick, N., Dadwal, S., Aldoss, I., Nakamura, R., Zaia, J.A., and Diamond, D.J. MVA Vaccine Encoding Cmv Antigens Safely Induces Durable Expansion of CMV-Specific T Cells in Healthy Adults. Blood 129:114-25, 2017. https://dx.doi.org/10.1182/blood-2016-07-729756
     
  23. Lacoste, S., Bhatia, S., Chen, Y., Bhatia, R., and O'Connor, T.R. Autologous Hematopoietic Stem Cell Transplantation in Lymphoma Patients Is Associated with a Decrease in the Double Strand Break Repair Capacity of Peripheral Blood Lymphocytes. PLoS ONE 12:e0171473, 2017. https://dx.doi.org/10.1371/journal.pone.0171473
     
  24. Li, M., Chen, Q., and Yu, X. Chemopreventive Effects of Ros Targeting in a Murine Model of Brca1-Deficient Breast Cancer. Cancer Research 77:448-58, 2017. https://dx.doi.org/10.1158/0008-5472.CAN-16-2350
     
  25. Ma, H., Ursin, G., Xu, X., Lee, E., Togawa, K., Duan, L., Lu, Y., Malone, K.E., Marchbanks, P.A., McDonald, J.A., Simon, M.S., Folger, S.G., Sullivan-Halley, J., Deapen, D.M., Press, M.F., and Bernstein, L. Reproductive Factors and the Risk of Triple-Negative Breast Cancer in White Women and African-American Women: A Pooled Analysis. Breast Cancer Res 19:6, 2017. https://dx.doi.org/10.1186/s13058-016-0799-9
     
  26. Ma, X., Meng, Z., Jin, L., Xiao, Z., Wang, X., Tsark, W.M., Ding, L., Gu, Y., Zhang, J., Kim, B., He, M., Gan, X., Shively, J.E., Yu, H., Xu, R., and Huang, W. CAMK2gamma in Intestinal Epithelial Cells Modulates Colitis-Associated Colorectal Carcinogenesis Via Enhancing Stat3 Activation. Oncogene, 2017. https://dx.doi.org/10.1038/onc.2017.16
     
  27. Mohanty, S., Mohanty, A., Sandoval, N., Tran, T., Bedell, V., Wu, J., Scuto, A., Murata-Collins, J., Weisenburger, D.D., and Ngo, V.N. Cyclin D1 Depletion Induces DNA Damage in Mantle Cell Lymphoma Lines. Leukemia & Lymphoma 58:676-88, 2017. https://dx.doi.org/10.1080/10428194.2016.1198958
     
  28. Mortimer, J.E., Waliany, S., Dieli-Conwright, C.M., Patel, S.K., Hurria, A., Chao, J., Tiep, B., and Behrendt, C.E. Objective Physical and Mental Markers of Self-Reported Fatigue in Women Undergoing (Neo)Adjuvant Chemotherapy for Early-Stage Breast Cancer. Cancer, 2017. https://dx.doi.org/10.1002/cncr.30426
     
  29. Narayanan, N., Wang, Z., Li, L., and Yang, Y. Arginine Methylation of Usp9x Promotes Its Interaction with Tdrd3 and Its Anti-Apoptotic Activities in Breast Cancer Cells. Cell Discov 3:16048, 2017. https://dx.doi.org/10.1038/celldisc.2016.48
     
  30. Perez, E.M., Foley, J., Tison, T., Silva, R., and Ogembo, J.G. Novel Epstein-Barr Virus-Like Particles Incorporating Gh/Glebna1 or Gb-Lmp2 Induce High Neutralizing Antibody Titers and Ebv-Specific T-Cell Responses in Immunized Mice. Oncotarget 8:19255-73, 2017. https://dx.doi.org/10.18632/oncotarget.13770
     
  31. Roberts, C.M., Shahin, S.A., Wen, W., Finlay, J.B., Dong, J., Wang, R., Dellinger, T.H., Zink, J.I., Tamanoi, F., and Glackin, C.A. Nanoparticle Delivery of Sirna against Twist to Reduce Drug Resistance and Tumor Growth in Ovarian Cancer Models. Nanomedicine: Nanotechnology, Biology, and Medicine 13:965-76, 2017. https://dx.doi.org/10.1016/j.nano.2016.11.010
     
  32. Rolle, C.E., Tan, Y.H.C., Seiwert, T.Y., Vora, S., Kanteti, R., Hasina, R., Carey, G.B., Surati, M., Weichselbaum, R.R., Lingen, M.W., Vokes, E.E., and Salgia, R. Expression and Mutational Analysis of C-Cbl and Its Relationship to the Met Receptor in Head and Neck Squamous Cell Carcinoma. Oncotarget 8:18726-34, 2017. https://dx.doi.org/10.18632/oncotarget.9640
     
  33. Somlo, G., Frankel, P., Arun, B., Ma, C.X., Garcia, A., Cigler, T., Cream, L., Harvey, H., Sparano, J.A., Nanda, R., Chew, H.K., Moynihan, T., Goetz, M.P., Vahdat, L., Beumer, J.H., Hurria, A., Mortimer, J., Piekarz, R., Sand, S., Herzog, J., Van Tongeren, L.R., Ferry-Galow, K., Chen, A., Ruel, C., Newman, E., Gandara, D.R., and Weitzel, J.N. Efficacy of the Parp Inhibitor Veliparib with Carboplatin or as a Single Agent in Patients with Germline Brca1- or Brca2-Associated Metastatic Breast Cancer. Clinical Cancer Research, 2017. https://dx.doi.org/10.1158/1078-0432.CCR-16-2714
     
  34. Tew, B.Y., Hong, T.B., Otto-Duessel, M., Elix, C., Castro, E., He, M., Wu, X., Pal, S.K., Kalkum, M., and Jones, J.O. Vitamin K Epoxide Reductase Regulation of Androgen Receptor Activity. Oncotarget, 2017. https://dx.doi.org/10.18632/oncotarget.14639
     
  35. Tran, T.Q., Lowman, X.H., Reid, M.A., Mendez-Dorantes, C., Pan, M., Yang, Y., and Kong, M. Tumor-Associated Mutant P53 Promotes Cancer Cell Survival Upon Glutamine Deprivation through P21 Induction. Oncogene 36:1991-2001, 2017. https://dx.doi.org/10.1038/onc.2016.360
     
  36. Urak, R., Walter, M., Lim, L., Wong, C.W., Budde, L.E., Thomas, S., Forman, S.J., and Wang, X. Ex Vivo Akt Inhibition Promotes the Generation of Potent Cd19car T Cells for Adoptive Immunotherapy. J Immunother Cancer 5:26, 2017. https://dx.doi.org/10.1186/s40425-017-0227-4
     
  37. Wang, L., Miyahira, A.K., Simons, D.L., Lu, X., Chang, A.Y., Wang, C., Suni, M.A., Maino, V.C., Dirbas, F.M., Yim, J., Waisman, J., and Lee, P.P. Il6 Signaling in Peripheral Blood T Cells Predicts Clinical Outcome in Breast Cancer. Cancer Research 77:1119-26, 2017. https://dx.doi.org/10.1158/0008-5472.CAN-16-1373
     
  38. Wang, Y., Zhou, D., Phung, S., Warden, C., Rashid, R., Chan, N., and Chen, S. Sgk3 Sustains Eralpha Signaling and Drives Acquired Aromatase Inhibitor Resistance through Maintaining Endoplasmic Reticulum Homeostasis. Proceedings of the National Academy of Sciences of the United States of America 114:E1500-e08, 2017. https://dx.doi.org/10.1073/pnas.1612991114
     
  39. Wedeken, L., Luo, A., Tremblay, J.R., Rawson, J., Jin, L., Gao, D., Quijano, J., and Ku, H.T. Adult Murine Pancreatic Progenitors Require Epidermal Growth Factor and Nicotinamide for Self-Renewal and Differentiation in a Serum- and Conditioned Medium-Free Culture. Stem Cells Dev 26:599-607, 2017. https://dx.doi.org/10.1089/scd.2016.0328
     
  40. Yoon, S., Huang, K.W., Reebye, V., Spalding, D., Przytycka, T.M., Wang, Y., Swiderski, P., Li, L., Armstrong, B., Reccia, I., Zacharoulis, D., Dimas, K., Kusano, T., Shively, J., Habib, N., and Rossi, J.J. Aptamer-Drug Conjugates of Active Metabolites of Nucleoside Analogs and Cytotoxic Agents Inhibit Pancreatic Tumor Cell Growth. Mol Ther Nucleic Acids 6:80-88, 2017. https://dx.doi.org/10.1016/j.omtn.2016.11.008
     
  41. Zhou, L., Dai, H., Wu, J., Zhou, M., Yuan, H., Du, J., Yang, L., Wu, X., Xu, H., Hua, Y., Xu, J., Zheng, L., and Shen, B. Role of Fen1 S187 Phosphorylation in Counteracting Oxygen-Induced Stress and Regulating Postnatal Heart Development. FASEB Journal 31:132-47, 2017. https://dx.doi.org/10.1096/fj.201600631R
     
  42. Zhou, Y., Copeland, B., Otto-Duessel, M., He, M., Markel, S., Synold, T.W., and Jones, J.O. Low Testosterone Alters the Activity of Mouse Prostate Stem Cells. Prostate 77:530-41, 2017.
    https://dx.doi.org/10.1002/pros.23290