Daniel Abler is a PhD physicist with research experience in applied physics, software- and computational bio-engineering. He has been actively involved in multidisciplinary research for 10 years, collaborating with engineers, computer scientists, biologists and clinicians. At the European Organization for Nuclear Research (CERN), Daniel studied technical feasibility of a new accelerator-based research infrastructure for ion-beam radiobiology. He also investigated model-driven data collection approaches to address semantic interoperability challenges in the context of ion-beam radiotherapy. Over the past 4 years, Daniel has been working on image-based computational models for various body-sites and medical conditions. His current research focuses on the effect of biomechanical forces on the formation and development of brain tumors and possible implications for treatment; he develops mathematical models to investigate this question. Daniel is interested in model-based computational approaches for integrating clinical and pre-clinical information into decision processes. He hopes that these efforts will ultimately improve the treatment of individual patients and facilitate the quantitative assessment of therapeutic approaches. Daniel has strong experience in the implementation of image-based finite-element models, related image and data processing, and analysis. His current research appointment as Marie SkÅ‚odowska-Curie Fellow was shared between City of Hope and the University of Bern, Switzerland.
C. Laurel Anderson
C. Laurel Anderson is currently a Data Scientist in the Department of Data Science and Artificial Intelligence at Integra Connect, which is a value-based, precision medicine company. Her educational background includes a BSc in Neuroscience from the University of Miami and an MSc in Human Genetics and Genomic Data Analytics from the Keck Graduate Institute. Before joining Integra Connect, she interned under Dr. Russell C. Rockne at City of Hope (Department of Computational and Quantitative Medicine, Division of Mathematical Oncology and Computational Systems Biology). After her internship, she transferred to the Department of Applied AI and Data Science for a Data Science Fellowship. During her time at City of Hope, she utilized mathematical and machine learning models to investigate the disease progression of Acute Myeloid Leukemia in human and mice data. Her fondest memories at City Hope were spent with Dr. Rockne’s team, where she learned invaluable skills and life lessons that she will always cherish for the rest of her life. Laurel was, and still is, a social butterfly. So if you would like to chat with her about her amazing mathematical oncology internship experience or if you just want to expand your professional network, then please feel free to connect with her on LinkedIn!
Soham Bose is a rising senior at Troy High School fascinated by the intersection of mathematics, computer science, and biology. At school, he is the president of Math Club, captain of the Science Bowl team, and on the varsity tennis team. Some of his hobbies include reading and playing piano, basketball, and video games. Previously, he has worked on research to create ODE models of the reverse Warburg effect and explore the effects of different agents on specific gene expression in mouse fibroblasts. Currently, he was a participant in City of Hope’s Eugene and Ruth Roberts Summer Academy working under Dr. Rockne in the Division of Mathematical Oncology and Computational Systems Biology. Later, as an undergrad and in his career, he hopes to pursue computational biology and applied math.
Alex Brummer is a PhD physicist with research experience in mathematical biology and ecology and evolutionary biology. His research aims to develop and test mathematical models of cancer growth and treatment response. He worked jointly with Dr. Russell Rockne (Division of Mathematical Oncology and Computational Systems Biology, Beckman Research Institute) examining cancer treatment response in glioblastoma, breast cancer, and leukemia; and with Dr. Van Savage (Computational Medicine, UCLA) studying imaging biomarkers of lung cancer derived from pulmonary vasculature. Alex is interested in understanding and predicting large scale phenomena from small scale interactions and optimizations. His research leverages elements from non-linear dynamics, population ecology, fluid mechanics, fractal geometry, spatial networks, shape analysis, computer vision, and allometric scaling theory. His work with Dr. Rockne is currently focused on (i) studying how different nonlinear model interactions between glioblastoma and CAR T-cells give way to various growth trajectories, and (ii) using data-driven, sparse identification techniques to discover underlying interactions. Alex is currently tenure-track faculty in Physics at the College of Charleston in Charleston, South Carolina.
Past Summer Trainee
Michael Cork is a recent graduate of Pomona College, where he received his B.A. in Mathematics with a minor in Biology and Spanish. During his time at Pomona, Michael explored how mathematical models can further our understanding of how cancer oversteps and rewires certain checkpoints in the immune system. Originally from Minneapolis, Minnesota, he has also conducted clinical research at Hennepin County Medical Center, as well as participated in various summer research programs aimed at modeling different biological and physical systems. When he is not investigating the interplay of math and biology, Michael enjoys reading, hiking, discovering new craft breweries and supporting Manchester United.
Jennifer Gutierrez has returned to Roberts Summer Academy after working with Dr. Russell Rockne in the Division of Mathematical Oncology. She participated in the summer academy last year with Dr. Tijana Talisman in the Department of Cancer Biology and Molecular Medicine where she studied the quantification of super-resolution data. She graduated from Mount Saint Mary's University (Los Angeles) in May 2016 where she obtained her baccalaureate degree in Mathematics. In her last year as an undergraduate, she was recognized with an Excellence in Mathematics Award as well as the Courage Award. She is interested in incorporating the language of mathematics in real-world applications and hence plans to pursue higher education in Biostatistics, Computational Biology, or Applied Mathematics. While some of her hobbies include, but are not limited to, running, water-coloring, biking, and learning new languages, her ultimate goal is to give back to her alma mater by teaching and providing mentorship to young women pursuing STEM degrees.
Amy Jang is a rising sophomore at Columbia University, majoring in biomedical engineering. Amy has previously done research at USC Information Science Institute where she published her work on “Designing an Ontology for the ENIGMA Neuroscience Collaboration” and on the “Automatic Generation of Portions of Scientific Papers for Large Multi-Institutional Collaborations Based on Semantic Metadata.” Additionally, she won the Best Interdisciplinary Collaboration award at IKCAP and the Best Poster Award at the INCF Neuroinformatics Congress. Amy also collaborated with Edwards Lifesciences to create a prototype version of an automated heart valve sewing machine. During the school year, she is working on identifying neuro-biomarkers for Huntington’s and Parkinson’s Disease patients at the Neurorehabilitation Research Lab and on identifying the relationship between speakers’ gestures and audience comprehension at the Columbia Engineering Laboratory for Intelligent Imaging and Neural Computing. Outside of biology and computer science, Amy loves to play piano and being up in the sky, whether that be ziplining or parasailing, and she hopes to skydive and bungee jump sometime in the future!
Aleksandra (Ola) Karolak
Aleksandra (Ola) Karolak is an Assistant Professor in the Department of Machine Learning at Moffitt Cancer Center. Previously, she was an Assistant Research Professor in Population Sciences at City of Hope, working jointly with Dr. Jeannine McCune (Population Sciences and Hematology & HCT) and Dr. Russell Rockne (Mathematical Oncology) on improvements of outcomes of the patients with hematopoietic stem cell transplants. Dr. Karolak obtained a MSc in metal-organic chemistry of bio-inorganic polymers and transition metals complexes from the Adam Mickiewicz University in Poland. During PhD at the University of South Florida in Tampa, she studied computational and biophysical chemistry. While at USF, she applied and developed computational methods for the conformational studies of biomolecules on various levels of resolution including ab initio, atomistic and coarse- grained models of small molecules, proteins and DNA. Her first postdoctoral training in the Mathematical Oncology Department at Moffitt Cancer Center in Tampa focused on applications of theoretical and computational methods in clinically relevant settings. At Moffitt, she worked on 2D models of imaging agents penetration through the tumor tissue, and 3D models of tumor organoids growth. Her desire to more completely contribute to the field of precision medicine led her to the Institute for Research in Biomedicine in Barcelona, Spain where her postdoctoral training was jointly funded by MSCA actions and BIST. At IRB, she applied multi-omics and machine learning approaches to uncover the structural signatures of cancer mutations in individual or subgroups of patients. In her research she combines approaches from computational and biophysical chemistry, structural biology, mathematical oncology and biostatistics to elucidate the role of heterogeneity in cancer progression and response to treatment. She seeks to understand variations in disease evolution, variability in the response to treatment and development of resistance, and how this knowledge, explored on the multi-scaled resolution levels using highly interdisciplinary approach, can be utilized to improve the outcomes of individual patients.
David Khachatrian is a rising senior at UCLA, studying bioengineering. In addition to his studies, David spends his time tutoring and leading review sessions for core undergraduate STEM courses as Academic Outreach officer for the UCLA chapter of Tau Beta Pi. When he gets the chance to relax, you will likely find him bouldering or playing his accordion. David previously conducted research in Dr. Karen Aboody's lab profiling a novel neural stem cell line, and gained a more quantitative understanding on biological phenomena during his time in the Division of Mathematical Oncology and Computational Systems Biology to supplement his academic studies and for a more broad appreciation of biological processes. In the future, David hopes to use this background to develop a functional method of using computer-aided protein engineering to treat a variety of diseases.
Davide joined the Division of Mathematical Oncology and Computational Systems Biology in March 2017. He obtained a Master Degree in Theoretical Physics in 2011 at Univerista`degli Studi di Torino (Italy) with a final project on the study of Bose-Einstein Condensates (BECs). He then moved to the University of East Anglia (UK) where in 2016 he obtained a Ph.D. in Applied Mathematics focusing on the study of quantized vortices in BECs in confined geometries by using a statistical mechanical approach. Davide's research covers non-linear physics, non-equilibrium statistical mechanics, dynamical systems and mathematical modeling of cancer dynamics. In particular, he is currently working on the developing of a mathematical model of Acute Myeloid Leukemia.
Dhanya Mahesh is a twelfth grader at Monta Vista High School in Cupertino, CA. She is particularly interested in the field of Neuroscience and has ranked in the top 25 nationally at the Brain Bee, a neuroscience competition. She is a proud member of the Girls Who Code organization and has designed a novel headphone alert system which is currently patent pending. She has pursued research projects involving Alzheimer's disease as well as water pollution which have placed at both the Synopsys Science Fair and the Bay Area Research Exposition. Currently she is interested in computational diagnostics.
Manohara is a rising senior at Glendora High School. His favorite subjects are mathematics and science. He has been an active member of the GHS Academic Decathlon Club, and currently serves as its president. In his spare time he likes to play tennis, video games, read books, and play piano. During his internship at City of Hope he learned how mathematics is applied in real-life situations. He hopes to continue his passion for math by pursuing a career in engineering.
Jan Pineda is going into her senior year at UC Santa Barbara as a chemistry major. She was a participant in City of Hope's Eugene and Ruth Roberts Summer Student Academy working under Dr. Lusine Tumyan in collaboration with Dr. Rockne to study the influence of pharmacokinetics in breast cancer research. After undergrad, she is interested in obtaining her masters in medicinal chemistry or pursuing a career in water chemistry. In her free time, she likes to spend time with her friends, family and her dog, Lucy.
Prativa Sahoo has 10 years of experience (including a Ph.D.) in the field of magnetic resonance imaging post processing. She has been actively involved in the detailed study of MRI, perfusion imaging (DCE), diffusion imaging (DWI, DTI), mathematical modelling and algorithm development and implementation. She has extensive experience in Java and Matlab. In her four year industry experience, she has worked closely with clinicians and radiologists to understand the clinical needs and problems, and has have designed and developed DCE-MRI post processing tool and validated for 500 brain tumor patients. Currently it is being used in multiple centers in India and abroad (Italy, Korea, Thailand and Nepal). She has developed a new three compartmental kinetic model for DCE-MRI post processing and the work has been selected for coverpage publication in the Journal of Magnetic Resonance Imaging (JMRI). Over the years she has published 7 journal papers published and 26 ISMRM conforence proceedings. She is interested in developing new algorithims and MR methodologies to answer various clinical questions and also to explore new areas like rs-fMRI and CEST imaging.
Ryan Sun is a rising senior at Temple City High School with a tremendous interest in Mathematics and Biology. He is also an active member of his school's Science Olympiad and Science Bowl teams. Aside from being a student, he is also a golfer and car enthusiast. As an intern at City of Hope, Ryan Sun was a member of the Eugene and Ruth Roberts Summer Student Academy working under Dr. Russell Rockne in the Division of Mathematical Oncology and Computational Systems Biology. He wishes to explore career opportunities in the fields of mathematics and biology as well as apply his mathematical and scientific skills in a real world environment.