Pichiorri Lab Publications

Name: Pichiorri Lab Publications
Keywords: Pichiorri Lab Publications

Awuah D, Minnix M, Caserta E, Tandoh T, Adhikarla V, Poku E, Rockne R, Pichiorri F, Shively JE, Wang. Sequential CAR T cell and targeted alpha immunotherapy in disseminated multiple myeloma. Cancer Immunol Immunother. 2023 May 20. doi: 10.1007/s00262-023-03461-z. PubMed PMID: 37209218.
Dona AA, Sanchez JF, Palmer JM, Synold TW, Chiuppesi F, Thomas S, Caserta E, Singer M, Tandoh T, Chowdhury A, Krishnan A, Rosenzweig M, Diamond DJ, Rosen S, Pichiorri F, Dadwal S. Leflunomide confers rapid recovery from COVID-19 and is coupled with temporal immunologic changes. Journal of Immunological Sciences. 2023;7(1):9-27. doi: 10.29245/2578-3009/2023/1.1241
Holstein SA, Asimakopoulos F, Azab AK, Bianchi G, Bhutani M, Crews LA, Cupedo T, Giles H, Gooding S, Hillengass J, John L, Kaiser S, Lee L, Maclachlan K, Pasquini MC, Pichiorri F, Shah N, Shokeen M, Shy BR, Smith EL, Verona R, Usmani SZ, McCarthy PL. Proceedings from the Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Immune and Cellular Therapy in Multiple Myeloma. Transplant Cell Ther. 2022 Aug;28(8):446-454. doi: 10.1016/j.jtct.2022.05.019. Epub 2022 May 21. PubMed PMID: 35605882; PubMed Central PMCID: PMC9357156.
Martella M, Pichiorri F, Chikhale RV, Abdelhamid MAS, Waller ZAE, Smith SS. i-Motif formation and spontaneous deletions in human cells. Nucleic Acids Res. 2022 Apr 8;50(6):3445-3455. doi: 10.1093/nar/gkac158. PubMed PMID: 35253884; PubMed Central PMCID: PMC8989526.
Du L, Liu W, Pichiorri F, Rosen ST. SUMOylation inhibition enhances multiple myeloma sensitivity to lenalidomide. Cancer Gene Ther. 2022 Mar 25;. doi: 10.1038/s41417-022-00450-9. [Epub ahead of print] PubMed PMID: 35338347.
Du L, Liu W, Aldana-Masangkay G, Pozhitkov A, Pichiorri F, Chen Y, Rosen ST. SUMOylation inhibition enhances dexamethasone sensitivity in multiple myeloma. J Exp Clin Cancer Res. 2022 Jan 4;41(1):8. doi: 10.1186/s13046-021-02226-9. PubMed PMID: 34983615; PubMed Central PMCID: PMC8725350.
Adhikarla V, Awuah D, Brummer AB, Caserta E, Krishnan A, Pichiorri F, Minnix M, Shively JE, Wong JYC, Wang X, Rockne RC. A Mathematical Modeling Approach for Targeted Radionuclide and Chimeric Antigen Receptor T Cell Combination Therapy. Cancers (Basel). 2021 Oct 15;13(20). doi: 10.3390/cancers13205171. PubMed PMID: 34680320; PubMed Central PMCID: PMC8533817.
Wang H, Sun J, Zhang B, Zhao D, Tong H, Wu H, Li X, Luo Y, Dong D, Yao Y, McDonald T, Stein AS, Al Malki MM, Pichiorri F, Carlesso N, Kuo YH, Marcucci G, Li L, Jin J. Targeting miR-126 disrupts maintenance of myelodysplastic syndrome stem and progenitor cells. Clin Transl Med. 2021 Oct;11(10):e610. doi: 10.1002/ctm2.610. PubMed PMID: 34709739; PubMed Central PMCID: PMC8516361.
Zhang B, Nguyen LXT, Zhao D, Frankhouser DE, Wang H, Hoang DH, Qiao J, Abundis C, Brehove M, Su YL, Feng Y, Stein A, Ghoda L, Dorrance A, Perrotti D, Chen Z, Han A, Pichiorri F, Jin J, Jovanovic-Talisman T, Caligiuri MA, Kuo CJ, Yoshimura A, Li L, Rockne RC, Kortylewski M, Zheng Y, Carlesso N, Kuo YH, Marcucci G. Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML. J Hematol Oncol. 2021 Aug 9;14(1):122. doi: 10.1186/s13045-021-01133-y. PubMed PMID: 34372909; PubMed Central PMCID: PMC8351342.
Nguyen LXT, Zhang B, Hoang DH, Zhao D, Wang H, Wu H, Su YL, Dong H, Rodriguez-Rodriguez S, Armstrong B, Ghoda LY, Perrotti D, Pichiorri F, Chen J, Li L, Kortylewski M, Rockne RC, Kuo YH, Khaled S, Carlesso N, Marcucci G. Cytoplasmic DROSHA and non-canonical mechanisms of MiR-155 biogenesis in FLT3-ITD acute myeloid leukemia. Leukemia. 2021 Aug;35(8):2285-2298. doi: 10.1038/s41375-021-01166-9. Epub 2021 Feb 15. PubMed PMID: 33589748; PubMed Central PMCID: PMC8973317.
Minnix M, Adhikarla V, Caserta E, Poku E, Rockne R, Shively JE, Pichiorri F. Comparison of CD38-Targeted α- Versus β-Radionuclide Therapy of Disseminated Multiple Myeloma in an Animal Model. J Nucl Med. 2021 Jun 1;62(6):795-801. doi:10.2967/jnumed.120.251983. Epub 2020 Oct 30. PubMed PMID: 33127621; PubMed Central PMCID: PMC8729861.
Ghose J, Dona A, Murtadha M, Gunes EG, Caserta E, Yoo JY, Russell L, Jaime-Ramirez AC, Barwick BG, Gupta VA, Sanchez JF, Sborov DW, Rosen ST, Krishnan A, Boise LH, Kaur B, Hofmeister CC, Pichiorri F. Oncolytic herpes simplex virus infects myeloma cells in vitro and in vivo. Mol Ther Oncolytics. 2021 Mar 26;20:519-531. doi: 10.1016/j.omto.2021.02.009. eCollection 2021 Mar 26. PubMed PMID: 33738338; PubMed Central PMCID: PMC7940704.
Lewinsky H, Gunes EG, David K, Radomir L, Kramer MP, Pellegrino B, Perpinial M, Chen J, He TF, Mansour AG, Teng KY, Bhattacharya S, Caserta E, Troadec E, Lee P, Feng M, Keats J, Krishnan A, Rosenzweig M, Yu J, Caligiuri MA, Cohen Y, Shevetz O, Becker-Herman S, Pichiorri F, Rosen S, Shachar I. CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma. JCI Insight. 2021 Feb 22;6(4). doi: 10.1172/jci.insight.141683. PubMed PMID: 33465053; PubMed Central PMCID: PMC7934939.
Viola D, Dona A, Caserta E, Troadec E, Besi F, McDonald T, Ghoda L, Gunes EG, Sanchez JF, Khalife J, Martella M, Karanes C, Htut M, Wang X, Rosenzweig M, Chowdhury A, Sborov D, Miles RR, Yazaki PJ, Ebner T, Hofmeister CC, Forman SJ, Rosen ST, Marcucci G, Shively J, Keats JJ, Krishnan A, Pichiorri F. Daratumumab induces mechanisms of immune activation through CD38+ NK cell targeting. Leukemia. 2021 Jan;35(1):189-200. doi: 10.1038/s41375-020-0810-4. Epub 2020 Apr 16. PubMed PMID: 32296125; PubMed Central PMCID: PMC7572537.
Khalife J, Sanchez JF, Pichiorri F. Extracellular Vesicles in Hematological Malignancies: From Biomarkers to Therapeutic Tools. Diagnostics (Basel). 2020 Dec 9;10(12). doi: 10.3390/diagnostics10121065. Review. PubMed PMID: 33316884; PubMed Central PMCID: PMC7763630.
Pozhitkov A, Rosenzweig M, Pichiorri F, Gunes EG, Buettner R, Keats JJ, Rosen ST. Glucocorticoid receptor expression in multiple myeloma patients is a predictor of survival. Leuk Lymphoma. 2020 Dec;61(14):3493-3497. doi: 10.1080/10428194.2020.1811860. Epub 2020 Sep 13. PubMed PMID: 32921213; PubMed Central PMCID: PMC7752826.
Chen S, Rivaud P, Park JH, Tsou T, Charles E, Haliburton JR, Pichiorri F, Thomson M. Dissecting heterogeneous cell populations across drug and disease conditions with PopAlign. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28784-28794. doi: 10.1073/pnas.2005990117. Epub 2020 Oct 30. PubMed PMID: 33127759; PubMed Central PMCID: PMC7682438.
Krishnan A, Adhikarla V, Poku EK, Palmer J, Chaudhry A, Biglang-Awa VE, Bowles N, Nathwani N, Rosenzweig M, Sahebi F, Karanes C, Simpson J, Sanchez JF, Yamauchi D, Parayno M, Chowdhury A, Caserta E, Marcucci G, Rockne R, Wu AM, Wong J, Forman SJ, Colcher D, Yazaki P, Shively J, Pichiorri F. Identifying CD38+ cells in patients with multiple myeloma: first-in-human imaging using copper-64-labeled daratumumab. Blood Adv. 2020 Oct 27;4(20):5194-5202. doi: 10.1182/bloodadvances.2020002603. PubMed PMID: 33095874; PubMed Central PMCID: PMC7594407.
Nguyen DQ, Hoang DH, Nelson M, Nigam L, Nguyen VTT, Zhang L, Pham TKT, Ho HD, Nguyen DDT, Lam TQ, Tat TT, Elhajmoussa Y, Ly QT, Pichiorri F, Pullarkat V, Zhang B, Kuo YH, Marcucci G, Nguyen LXT. Requirement of GTP binding for TIF-90-regulated ribosomal RNA synthesis and oncogenic activities in human colon cancer cells. J Cell Physiol. 2020 Oct;235(10):7567-7579. doi: 10.1002/jcp.29661. Epub 2020 Mar 11. PubMed PMID: 32159236.
Rosenzweig M, Palmer J, Tsai NC, Synold T, Wu X, Tao S, Hammond SN, Buettner R, Duarte L, Htut M, Karanes C, Nathwani N, Pichiorri F, Sahebi F, Sanchez JF, Chowdhury A, Krishnan A, Forman SJ, Rosen ST. Repurposing leflunomide for relapsed/refractory multiple myeloma: a phase 1 study. Leuk Lymphoma. 2020 Jul;61(7):1669-1677. doi: 10.1080/10428194.2020.1742900. Epub 2020 Apr 8. PubMed PMID: 32268821; PubMed Central PMCID: PMC7384948.
Amparo C, Clark J, Bedell V, Murata-Collins JL, Martella M, Pichiorri F, Warner EF, Abdelhamid MAS, Waller ZAE, Smith SS. Duplex DNA from Sites of Helicase-Polymerase Uncoupling Links Non-B DNA Structure Formation to Replicative Stress. Cancer Genomics Proteomics. 2020 Mar-Apr;17(2):101-115. doi: 10.21873/cgp.20171. PubMed PMID: 32108033; PubMed Central PMCID: PMC7078840.
Wang H, Zhao D, Nguyen LX, Wu H, Li L, Dong D, Troadec E, Zhu Y, Hoang DH, Stein AS, Al Malki M, Aldoss I, Lin A, Ghoda LY, McDonald T, Pichiorri F, Carlesso N, Kuo YH, Zhang B, Jin J, Marcucci G. Targeting cell membrane HDM2: A novel therapeutic approach for acute myeloid leukemia. Leukemia. 2020 Jan;34(1):75-86. doi: 10.1038/s41375-019-0522-9. Epub 2019 Jul 23. PubMed PMID: 31337857; PubMed Central PMCID: PMC7951797.
Khalife J, Ghose J, Martella M, Viola D, Rocci A, Troadec E, Terrazas C, Satoskar AR, Gunes EG, Dona A, Sanchez JF, Bergsagel PL, Chesi M, Pozhitkov A, Rosen S, Marcucci G, Keats JJ, Hofmeister CC, Krishnan A, Caserta E, Pichiorri F. MiR-16 regulates crosstalk in NF-κB tolerogenic inflammatory signaling between myeloma cells and bone marrow macrophages. JCI Insight. 2019 Nov 1;4(21). doi: 10.1172/jci.insight.129348. PubMed PMID: 31593552; PubMed Central PMCID: PMC6948777.
Nguyen LXT, Troadec E, Kalvala A, Kumar B, Hoang DH, Viola D, Zhang B, Nguyen DQ, Aldoss I, Ghoda L, Budde E, Pichiorri F, Rosen S, Forman SJ, Marcucci G, Pullarkat V. The Bcl-2 inhibitor venetoclax inhibits Nrf2 antioxidant pathway activation induced by hypomethylating agents in AML. J Cell Physiol. 2019 Aug;234(8):14040-14049. doi: 10.1002/jcp.28091. Epub 2019 Jan 8. PubMed PMID: 30623427; PubMed Central PMCID: PMC8852851.
Buettner R, Morales C, Caserta E, Troadec E, Gunes EG, Viola D, Khalife J, Li H, Keats JJ, Christofferson A, Wu X, Synold TW, Palmer J, Sanchez JF, Pozhitkov A, Vaidehi N, Marcucci G, Krishnan A, Rosenzweig MA, Pichiorri F, Rosen ST. Leflunomide regulates c-Myc expression in myeloma cells through PIM targeting. Blood Adv. 2019 Apr 9;3(7):1027-1032. doi: 10.1182/bloodadvances.2018027227. PubMed PMID: 30940637; PubMed Central PMCID: PMC6457239.

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