An NCI-designated Comprehensive Cancer Center

Every department of Beckman Research Institute of City of Hope includes internationally-acclaimed scientists and support staff who are among the best in their respective fields, pursuing a diverse range of research. The result? A history of breakthrough innovations helping patients here and around the world, with even more to come in the years ahead.


Uncovering the basic mechanisms of genetics, gene expression and function, signaling pathways, mutagenesis, DNA repair and epigenetics as they relate to the development and progression of cancer.


Studies here are focused on discovering the fundamental mechanisms of DNA replication and DNA damage repair during cell growth.



The Center for Cancer and Aging unites investigators from all cancer disciplines to study biology, treatment and survivorship issues that face older adults with cancer.


For patients with diabetes and other endocrine or metabolic disorders, therapy options and management approaches for diabetes and endocrinology are more plentiful than ever. Treatment is tailored to the individual, with the type of disease and its severity determining the optimal course of treatment.


The Department of Computational and Quantitative Medicine within the Beckman Research Institute was created to integrate various aspects of computational medicine. It is charged with building cross-disciplinary collaborations and developing better diagnostic tools, improved personalized therapies and more efficient clinical trials, consistent with the mission of City of Hope.


Offering a multidisciplinary research and training environment in neurobiology with a particular focus on developmental aspects of the nervous system.


Led by Joyce Niland, Ph.D., the Department of Diabetes & Cancer Discovery Science within the Diabetes & Metabolism Research Institute provides leading-edge research to support advances in diabetes, metabolism and oncology research.


The Department of Diabetes Complications & Metabolism, directed by Rama Natarajan, Ph.D., is at the forefront of research on the complications of diabetes and was the first to study epigenetic changes in diabetic complications.


The Department of Diabetes Immunology, headed by Bart O. Roep, Ph.D., is dedicated to studying immune system mechanisms and their impact on diabetes development and control — particularly type 1 diabetes.


By improving the understanding of leukemia stem cells, researchers are working at developing cures for leukemia and other hematologic malignancies.


Researchers in the Department of Immuno-Oncology are pioneering medical science that harnesses the power of the body’s own immune system to fight cancer. They intend to move immunotherapy forward to the front lines by making it a highly effective primary treatment option, capable of producing more powerful, less toxic cures.


Our Lymphoma Specialized Program of Research Excellence (SPORE) is developing translational studies to improve the detection and therapy of lymphoma, Hodgkin and non-Hodgkin Lymphoma.



The Department of Molecular and Cellular Biology studies an array of biological systems and problems, focusing on the mechanisms regulating expression of genetic information at both the transcriptional level and the post-transcriptional level.


The Department of Molecular & Cellular Endocrinology, headed by Debbie C. Thurmond, Ph.D., is pioneering efforts to investigate biological mechanisms involved with type 1 and type 2 diabetes development and substances that promote or interfere with those processes.


The molecular diagnostics and experimental therapeutics research program has a broad research focus on understanding the molecular pathogenesis of human gastrointestinal cancers and its relationship to early detection of cancer, cancer prevention and cancer therapeutics.


With a dual focus on molecular immunology and structural biology, principal investigators here are researching cell and tumor immunology and structure analysis.


Scientist here are investigating the mechanisms underlying cancer and other diseases to develop novel molecular therapeutics.


Researchers across multiple divisions are targeting what causes cancer, how to prevent people from getting cancer, and how to improve the quality of life of cancer survivors.



The Department of Systems Biology aims to understand the complex biological systems involved in signal transduction and in the transcriptional, epigenetic and metabolic regulation of hematological malignancies, leukemia and lymphoma.


Led by Fouad Kandeel, M.D., Ph.D., this department focuses on stem cell biology and development, translational immunology, islet imaging, isolation and distribution, islet quality assessment and new drug discoveries to improve diabetes treatment and management.