An NCI-designated Comprehensive Cancer Center

Leo Wang Lab

Leo Wang Lab Overview
Protein-Focused Stem Cell Research
Leo Wang Lab Overview
Our research focuses on using leading-edge mass spectrometric technologies to identify novel activation pathways in small numbers of blood cells. Our 2D-LC/MS3 platform enables us to phosphoproteomically profile hematopoietic stem and progenitor cells, leukemia cells and immune cells as they undergo state and fate transitions.
 
These strategies, combined with in vitro and in vivo model systems, will enable us to understand and to treat pediatric blood cancers and solid tumors more effectively.
 
To view all research highlights, please visit Leo Wang Lab's Research Highlights.

Principal Investigator

Leo David Wang, M.D., Ph.D.
Pediatric Hematologist - Oncologist
Role: Principal Investigator
Research Focus: Benign and malignant hematopoietic stem cells

Principal Investigator

Leo David Wang, M.D., Ph.D.
Pediatric Hematologist - Oncologist
Role:Principal Investigator
Research Focus: Benign and malignant hematopoietic stem cells

Lab Members

Marly Coe
Marly Coe graduated from Scripps College in 2018 with a Bachelor of Arts in biochemistry. For their senior thesis, Coe spent a summer in Dr. Leonard Mueller’s lab at UC Riverside, growing and purifying isotopically labelled protein for the lab’s protein NMR experiments, as well as contributing to the computational modelling of point mutations in the protein’s active site. Coe was exposed to a large amount of basic chemistry and molecular biology lab techniques throughout their college coursework, and they look forward to the opportunity to expand upon that technical knowledge in the Wang lab. A lifelong science lover, Coe is excited to work with human cells and to take part in research that has a direct impact on human healing and the treatment of cancer.
 
 
Martha Gomez-Knight
Martha Gomez-Knight brings extensive expertise navigating the complex administrative systems at City of Hope. Although her critical contributions to the Wang lab are too numerous to list exhaustively, some of her responsibilities include managing laboratory finances, coordinating laboratory logistical support, onboarding new members, organizing and coordinating schedules, event planning, and "making things happen."

Gomez-Knight often serves as the first point of contact for the lab, and any inquiries can be directed to her at [email protected]. She is dedicated to service outside of her career as well, and she volunteers with her church parish to help those who are less fortunate.

 
Stephanie Huard
Stephanie Huard earned her Bachelor of Science from California Institute of Technology in 2018 with a double-major in biology and philosophy. While at Caltech, she did research in the laboratory of Henry Lester, studying the differential expression and trafficking of nicotinic acetylcholine receptor subunits in the presence of nicotine and menthol. Huard looks forward to experiencing the clinical research environment at City of Hope and developing her technical proficiency in diverse biological and proteomic techniques, and she is excited to join the Wang Lab in the study of benign and malignant hematopoietic disorders.
 
 
 
Sadie Johnson, Ph.D.
Sadie Johnson obtained her Bachelor of Science in chemical engineering at University of Kansas in 2012. She completed her Ph.D. in chemical engineering at University of Minnesota under the advisement of Ben Hackel, Ph.D., in 2018. Her research focused on developing novel multidomain peptides and proteins with improving ligand selectivity for a variety of molecular imaging modalities.

Johnson aims to apply her protein engineering background to a variety of complex questions within the field of immunology and hematology. She is excited for the opportunity to develop novel ligands for hematopoietic stem cell targeting and to characterize signaling networks within CAR T cells.
 
 
Silke Lindner, Ph.D.
Silke Lindner began her biology studies at Technical University in Darmstadt before she relocated to Freiburg im Breisgau, Germany, to complete her Ph.D. in the field of apoptosis at Albert-Ludwigs-University. Her research conducted in the laboratories of Dr. Ulrich Maurer and Dr. Christoph Borner focused on the impact of cell death signaling and survival in cancer as well as the immune system. She followed up with her research in the Developmental Immunology groups of Dr. Andreas Villunger and Dr. Sebastian Herzog at the Medical University of Innsbruck, Austria. The main focus of Lindner’s work was to decipher the role of noncoding RNAs and microRNAs in haematopoiesis, early B cell development, and cancer development.

In addition to deepening her knowledge in the tumor immunology field, Lindner is eager to acquire technical expertise in cross-discipline techniques and extend her scientific profile towards benign and malignant hematopoietic stem cells.
 
 
Antigoni Manousopoulou, M.D., Ph.D.
Antigoni Manousopoulou studied medicine in Athens, Greece before moving to Southampton, U.K. At the University of Southampton, she completed a master’s degree in public health nutrition and a Ph.D. in clinical proteomics.

In the Wang Lab, Manousopoulou uses mass spectrometry to examine the proteomic and phosphoproteomic profiles of cells, tissue and blood. This phenotypic profiling of clinical samples can provide insight into the pathophysiology of disease and can also help identify novel drug targets, as well as predictive, diagnostic and prognostic biomarkers.
 
 
MeiLu McDermott
MeiLu McDermott dual majored in chemistry and astronomy at Williams College in Massachusetts, obtaining her Bachelor of Arts in 2016. She additionally studied computer science while earning her degree. In her undergraduate research, she focused this background on characterizing planetary nebulae in the Andromeda Galaxy based on emission spectra, using photoionization simulations. She has also applied her database skills to retrospective analyses of breast cancer biopsies specimens relative to initial tumor size to inform technique for diagnostic tissue sampling while at LA Biomed at Harbor-UCLA Medical Center.

McDermott is excited to join the Wang Lab, directing her focus on proteomic and phosphoproteomic analysis from high-throughput mass spectrometry data to better characterize signaling pathways in benign and malignant pediatric hematopoietic disorders as well as CAR T cells.
 

Lab Alumni

  • Nathan Hendricks, Ph.D.
  • Chris Meeks
  • Shilpa Shahani, M.D.

Lab Publications

Default publication image
Leo Wang's Publications
To view a complete list of publications, please click the link below.

Research Support

Pediatric cancer research is woefully underfunded; only 4 percent of the budget of the National Cancer Institute is dedicated to this critically important work.

We rely on support from foundations and other philanthropic sources to keep our lab running and to continue our work to find cures for pediatric brain and blood cancers.

We thank all of our wonderful donors for their past, current and future support.
 

 

Current Support

 

Previous Support

Leo David Wang Bio Photo

The complex process of cell division is being studied at City of Hope by a team of stem cell biologists led by Leo David Wang, M.D., Ph.D.


Leo Wang

Dual-trained pediatric oncologist and scientist Leo Wang, M.D., Ph.D., is working in the lab to understand how blood cells develop and grow, and plans to use that information to help patients with cancer live longer and experience fewer side effects of treatment.


For more about the Leo Wang Lab in the news, please visit:

Join the Leo Wang Lab Team

The goal of the Leo Wang Lab is to revolutionize the way that pediatric and blood cancers are treated, and we could not be more thrilled to bring our innovative and exciting scientific research group to the San Gabriel Valley.
 
We are looking for enthusiastic, self-motivated individuals who thrive in a fast-paced, challenging startup research environment, and who can interact well with others as part of a cohesive team. If you have a desire to make a significant impact in health care, and have the fortitude to work hard, we invite you to contact us.

Lab Location & Contact

Leo Wang Lab
1500 East Duarte Road,
Duarte, CA 91010
Ample Free Parking