Our Team

Marly Coe
Marly Coe graduated from Scripps College in 2018 with a Bachelor of Arts in biochemistry. For their senior thesis, Coe spent a summer in Dr. Leonard Mueller’s lab at UC Riverside, growing and purifying isotopically labelled protein for the lab’s protein NMR experiments, as well as contributing to the computational modelling of point mutations in the protein’s active site. Coe was exposed to a large amount of basic chemistry and molecular biology lab techniques throughout their college coursework, and they look forward to the opportunity to expand upon that technical knowledge in the Wang lab. A lifelong science lover, Coe is excited to work with human cells and to take part in research that has a direct impact on human healing and the treatment of cancer.
 
 
 
Martha Gomez-Knight
Martha Gomez-Knight brings extensive expertise navigating the complex administrative systems at City of Hope. Although her critical contributions to the Wang lab are too numerous to list exhaustively, some of her responsibilities include managing laboratory finances, coordinating laboratory logistical support, onboarding new members, organizing and coordinating schedules, event planning, and "making things happen."

Gomez-Knight often serves as the first point of contact for the lab, and any inquiries can be directed to her at [email protected]. She is dedicated to service outside of her career as well, and she volunteers with her church parish to help those who are less fortunate.
 

 
Stephanie Huard
Stephanie Huard earned her Bachelor of Science from California Institute of Technology in 2018 with a double-major in biology and philosophy. While at Caltech, she did research in the laboratory of Henry Lester, studying the differential expression and trafficking of nicotinic acetylcholine receptor subunits in the presence of nicotine and menthol. Huard looks forward to experiencing the clinical research environment at City of Hope and developing her technical proficiency in diverse biological and proteomic techniques, and she is excited to join the Wang Lab in the study of benign and malignant hematopoietic disorders.
 
 
Sadie Johnson, Ph.D.
Sadie Johnson obtained her Bachelor of Science in chemical engineering at University of Kansas in 2012. She completed her Ph.D. in chemical engineering at University of Minnesota under the advisement of Ben Hackel, Ph.D., in 2018. Her research focused on developing novel multidomain peptides and proteins with improving ligand selectivity for a variety of molecular imaging modalities.

Johnson aims to apply her protein engineering background to a variety of complex questions within the field of immunology and hematology. She is excited for the opportunity to develop novel ligands for hematopoietic stem cell targeting and to characterize signaling networks within CAR T cells.
 
 
Silke Lindner, Ph.D.
Silke Lindner began her biology studies at Technical University in Darmstadt before she relocated to Freiburg im Breisgau, Germany, to complete her Ph.D. in the field of apoptosis at Albert-Ludwigs-University. Her research conducted in the laboratories of Dr. Ulrich Maurer and Dr. Christoph Borner focused on the impact of cell death signaling and survival in cancer as well as the immune system. She followed up with her research in the Developmental Immunology groups of Dr. Andreas Villunger and Dr. Sebastian Herzog at the Medical University of Innsbruck, Austria. The main focus of Lindner’s work was to decipher the role of noncoding RNAs and microRNAs in haematopoiesis, early B cell development, and cancer development.

In addition to deepening her knowledge in the tumor immunology field, Lindner is eager to acquire technical expertise in cross-discipline techniques and extend her scientific profile towards benign and malignant hematopoietic stem cells.
 
 
Antigoni Manousopoulou, M.D., Ph.D.
Antigoni Manousopoulou studied medicine in Athens, Greece before moving to Southampton, U.K. At the University of Southampton, she completed a master’s degree in public health nutrition and a Ph.D. in clinical proteomics.

In the Wang Lab, Manousopoulou uses mass spectrometry to examine the proteomic and phosphoproteomic profiles of cells, tissue and blood. This phenotypic profiling of clinical samples can provide insight into the pathophysiology of disease and can also help identify novel drug targets, as well as predictive, diagnostic and prognostic biomarkers.
 
 
MeiLu McDermott
MeiLu McDermott dual majored in chemistry and astronomy at Williams College in Massachusetts, obtaining her Bachelor of Arts in 2016. She additionally studied computer science while earning her degree. In her undergraduate research, she focused this background on characterizing planetary nebulae in the Andromeda Galaxy based on emission spectra, using photoionization simulations. She has also applied her database skills to retrospective analyses of breast cancer biopsies specimens relative to initial tumor size to inform technique for diagnostic tissue sampling while at LA Biomed at Harbor-UCLA Medical Center.

McDermott is excited to join the Wang Lab, directing her focus on proteomic and phosphoproteomic analysis from high-throughput mass spectrometry data to better characterize signaling pathways in benign and malignant pediatric hematopoietic disorders as well as CAR T cells.
 
 
 
Leo David Wang earned his undergraduate degree in molecular biophysics and biochemistry from Yale University, followed by his Ph.D. and medical doctorate at the University of Chicago. He successfully completed an internship and residency in pediatrics at the Children’s Hospital of Philadelphia. Wang then completed his pediatric hematology/oncology/stem cell transplantation fellowship at the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, and pursued postdoctoral research in the laboratory of Amy Wagers, Ph.D., at the Joslin Diabetes Center and Harvard Stem Cell Institute.

Board-certified in pediatrics and pediatric hematology/oncology, Wang is the recipient of multiple honors and awards, including a Damon-Runyon Foundation Cancer Research Fellowship, a St. Baldrick’s Scholar Award and an Alex’s Lemonade Stand Foundation Young Investigator Award.

Wang will attend the pediatric oncology and stem cell transplant services while maintaining an active research laboratory. His research focuses on utilizing novel mass spectrometry-based phosphoproteomic techniques to identify targetable activation pathways in small numbers of rare cells. He plans to continue this work on benign and malignant hematopoietic stem cells, as well as to extend his research to investigate critical pathways important in the immune response to cancer. Ultimately, he plans to create a research program that bridges clinical oncology and bone marrow transplantation with fundamental mechanistic research, permitting the translation of novel laboratory findings into clinically important interventions.
 

Lab Alumni

  • Nathan Hendricks, Ph.D.
  • Chris Meeks
  • Shilpa Shahani, M.D.