Soo Jun
Postdoctoral Fellow
Research Focus Demonstration of the underlying mechanisms of LFPRLR's role in pathogenic B-cell subsets and its therapeutic valueEducation1997: Daugu University, South Korea2016: Korea Research Institute of Biotechnology and Bioscience, South KoreaProfessional Experience2001~2008: Korean Oriental Physiology Lab at Dongguk University, South Korea2008~2010: Dr. May e Choi's Lab at Brigham and Women's Hospital/Harvard Medical School2011-2023: Dr. Kim NS' Lab, Rare Disease Department, Korea Research Institute of Biotechnology and Bioscience, South Korea2023-2023: Dr. Zijie Sun Lab, at City of Hope2024-current: Dr. Srividya Swaminathan Lab at City of HopeAwardsChairman's Award, National Science and Technology Research Association (January 27, 2022)Distinguished Post Award in BIEN2021, The international conference of women scientists and engineers conference on BT, IT, ET, and NT (August 19, 2021), Best Performance Award in the 34th anniversary of the KRIBB foundation (February 1, 2019)Selected for WISET Overseas Exchange Program (July 6, 2017)President Award in the graduate ceremony (August 19, 2016)Selected for UST Overseas Exchange Program (April 1, 2015)UST Award for graduate students who achieved outstanding research (June 14, 2013).KRIBB Award for the Outstanding Researcher (December 28, 2012)MembershipsAssociate Member, American Association for Cancer Research (2015~current)PublicationsJun SY, Yoon JY, Yoon JY, Lee JJ, Kim JY, Kim JM, and Kim NS Age-related cholesterol and colorectal cancer progression: Validating squalene epoxidase for high-risk cases. Aging Cell, 2024, Mar 22:e14152. Doi: 10.1111/ace;/14152Debasish H, Jeon SJ, Yoon JY Lee JJ, Jun SY, Choi MH, Jeong BH, Sung DH, Lee DY, Kim BJ, and Kim NS, TREX1 deficiency induces ER stress-mediated neuronal cell death by disrupting Ca2+ homeostasis. Molecular Neurobiology, 2022, 59(3):1398-1418. Yang JO*, Choi MH*, Yoon JY, Lee JJ, Nam SO, Jun SY, Kwon HH, Yun SH, Jeon SJ, Hyeon IS, Debasish Halder, Kong JH, Lee BW, Lee JH, Kang JW, and Kim NS, Characteristics of genetic variations associated with Lennox-Gastaut syndrome in Korean Families. Frontiers in Genetics, 2021, 11: 590924. Jun SY*, Brown AJ, Chua NK, Yoon JY, Lee JJ, Yang JO, Jang IS, Jeon SJ, Choi TI, Kim CH, and Kim NS, Reduction of squalene epoxidase by cholesterol accumulation accelerates colorectal cancer progression and metastasis. Gastroenterology, 2021, 160: 1194-1207. Yang JO*, Yoon JY*, Sung DH, Yun SH, Lee JJ, Jun SY, Debasish H, Jeon SJ, Woo EJ, Seok JM, Choi JW, Jang JH, Choi JK, Kim BJ, and Kim NS, The emerging genetic diversity of hereditary spastic paraplegia in Korean patients. Genomics, 2021, 113: 4136-4148. Jun SY*, Yoon HR, Yoon JY, Jeon SJ, Lee JJ, Halder D, Kim JM, and Kim NS, The human TOR signaling regulator is the key indicator of liver cancer patients’ overall survival: TIPRL/LC3/CD133/CD44 as potential biomarkers for early liver cancers. Cancers, 2021, 13: 2925.Choi MH*, Yang JO*, Min JS, Lee JJ, Jun SY, Lee YJ, Yoon JY, Jeon SJ, Byeon IS, Kang JW, and Kim NS, A novel X-lined variant of IQSEC2 is associated with Lennox-Gastaut Syndrome and mild intellectual disability in three generations of a Korean family. Genetic testing and molecular biomarkers, 2020, 24: 54-58. Min JS*, Debasish Halder*, Yoon JY, Jeon SJ, Jun SY, Lee JR, LJJ, Choi MH, Jung CR, Lee DY, Kim BJ, and Kim NS, Coiled-coil domain-containing 50-V2 protein positively regulates neurite outgrowth. Scientific reports, 2020, 10: 21295Jeon SJ*, Ahn JH*, Halder D, Cho HS, Lim JH, Jun SY, Lee JJ, Yoon JY, Choi MH, Jung CR, Kim JM, and Kim NS, TIPRL potentiates survival of lung cancer by inducing autophagy through the eIF2a-ATF4 pathway. Cell Death and Disease 2019, 10:959-976. Jun SY*, Jeon SJ*, Yoon JY, Lee JJ, Yoon HR, Choi MH, Debasish H, Lee K and Kim NS, The positive correlation between TIPRL with LC3 and CD133 contributes to cancer aggressiveness: potential biomarkers for early liver cancer. Scientific Reports, 2019, 9: 16802-16812. Yoon JI, Lee JJ, Gu S, Jung ME, Cho HS, Lim JH, Jun SY, Ahn JH, Min JS, Choi MH, Jeon SJ, Lee YJ, Go A, Heo YJ, Jung CR, Choi G, Lee K, Jeon MK, and Kim NS, Novel indazole-based small compounds enhance TRAIL-induced apoptosis by inhibiting the MKK7-TIPRL interaction in Huh7 cells. Oncotarget 2017, 8: 112610-112622. Lee JH*, Cho HS*, Lee JJ, Jun SY, Ahn JH, Min JS, Yoon JY, Choi MH, Jeon SJ, Lim JH, Jung CR, Kim DS, Kim HT, Factor VM, Lee YH, Thorqeirsson SS, Kim CH, and Kim NS, Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis. Oncotarget Nov 29 2016 7: 79774-79786. Yoon JY*, Cho HS*, Lee JJ, Lee HJ, Jun SY, Lee JH, Song HH, Choi S, Saloura V, Park CG, Kim CH, Kim NS, Novel TRAIL sensitizer Taraxacum officinale F.H.Wigg enhances TRAIL-induced apoptosis in Huh7 cells. Molecular Carcinogenesis 2016 55: 387-396. Lee HJ*, Cho HS*, Jun SY, Lee JJ, Yoon JY, Lee JH, Song HH, Choi SH, Kim SY, Saloura V, park CG, and Kim NS, Tussilage farfara L. augments TRAIL-induced apoptosis through MKK7/JNK activation by inhibition of MKK7-TIPRL in human hepatocellular carcinoma cells. Oncology reports 2014 32: 1117-1123. Song IS*, Jun SY*, Na HJ, Kim HT, Jung SY, Ha GH, Park YH, Long LZ, Yu DY, Kim JM, Kim JH, Ko JH, Kim CH, and Kim NS, Inhibition of MKK7-JNK by the TOR signaling pathway regulator-like protein contributes to resistance of HCC cells to TRAIL-induced apoptosis. Gastroenterology (one of the co-first authors) 2012 143: 1341-1351. Ding Y* Kim JK*, Kim SI*, Na HJ, Jun SY, Lee SJ, Choi ME, TGF-b1 protects against mesangial cell apoptosis via induction of autophagy. Journal of Biological Chemistry 2010 (2010.11.26) 285: 37909-37919. Jun SY*, Choi YH, and Shin HM, Siegesbeckia glabrescens induces apoptosis with different pathways in human MCF-7 and MDA-MB-231 breast carcinoma cells. Oncology Reports 2006 15: 1461-1467.
