Developmental Cancer Therapeutics In the News

Chen-Shiuan

Shiuan Chen, Ph.D., who heads City of Hope’s Natural Therapies Program, is studying the effects of white button mushrooms on prostate cancer patients. He previously found that phytochemicals in mushrooms had the ability to block the activity of an enzyme that contributes to breast cancer.


Microbes in Space | City of Hope

City of Hope clinicians and researchers are brimming with optimism as 2020 begins. Cancer care is changing rapidly, and the pace of change is accelerating. In 2020 look for major advances in gene-based therapy, immunotherapy and many other areas.


Chen-Shiuan

In a recently published study, City of Hope researchers demonstrate how external elements such as certain toxic chemicals can fundamentally change a cell’s composition and behavior in ways that may lead to cancer.


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City of Hope co-led a phase 3 clinical trial that may soon change how renal cell carcinoma patients are treated in third- and fourth-line therapies.

Rick Kittles

The National Cancer Institute awarded a grant to City of Hope with the goal of sparking passion for science among underrepresented minority youth in neighboring communities. YES2SUCCESS comprises a pipeline of outreach activities and hands-on participation in research from sixth grade through the undergraduate years.


Breast Cancer Cell 500X500

City of Hope is accelerating the development of treatment options for patients with breast cancer who have challenging tumors and poor prognosis with a phase 1 clinical trial that is enrolling patients with refractory HER2-positive breast cancer with brain metastases to test the safety and effectiveness of CAR T cell therapy.


Chen-Shiuan

Shiuan Chen, Ph.D., who heads City of Hope’s Natural Therapies Program, is studying the effects of white button mushrooms on prostate cancer patients. He previously found that phytochemicals in mushrooms had the ability to block the activity of an enzyme that contributes to breast cancer.


colorectal cancer screening

People with colon and rectal tumors prone to “immune overdrive” don’t do well if they concurrently have an immune-suppressive tumor microenvironment, City of Hope researchers say.


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People with colon and rectal tumors prone to “immune overdrive” don’t do well if they concurrently have an immune-suppressive tumor microenvironment, City of Hope researchers say.

rahul jandial headshot 256 x 256

Rahul Jandial, M.D., Ph.D., has received the “Breakthrough” award from the Department of Defense's Breast Cancer Research Program to support his study of leptomeningeal disease, which is characterized by the spreading of tumor cells to the lining of the brain and spinal cord.


Erminia Massarelli, M.D., Ph.D., profile photo

A first-in-human, phase 1 T cell trial for patients who have human papillomavirus (HPV)-associated cancers that have relapsed, or are resistant to treatment, is now open at City of Hope. The institution is the first to open such a trial on the West Coast.


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Today City of Hope announced the artists and creators who will receive special recognition at the Music, Film and Entertainment Industry Group’s 15th Annual Songs of Hope next month.

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On the West Coast, City of Hope is the first institution to open the Kite-sponsored trial.

Yuman Fong | City of Hope

An ongoing clinical study in China on the drug showed liver tumor shrinkage, regression of metastatic tumors and fewer side effects than in other T cell clinical trials.


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City of Hope is the first institution in the United States to open an immunotherapy clinical trial for liver cancer that, if successful, eventually could transform treatment of the usually fatal disease into an outpatient procedure.

Nagarajan Vaidehi

Thanks to a new study by City of Hope scientists just published in Proceedings of the National Academy of Sciences of the United States of America, researchers may now be able to design a common class of drugs with minimal side effects.


Pancreatic Cancer Cell

The Pancreatic Cancer Action Network has awarded two City of Hope researchers — Yuan Chen, Ph.D., and Xiaochun Yu, M.D., Ph.D. — $500,000 Translational Research Grants — a total gift of $1 million.


Orange as Cancer Fighter | City of Hope

Sharad Singhal, Ph.D., research professor in the Department of Medical Oncology and Therapeutics Research, leads investigations focusing on a small molecule that is abundant in the pith of citrus fruit.


colorectal cancer screening

The takeaway of foundational research by a City of Hope physician-scientist and his colleagues is that patients with metastatic colorectal cancer and a high tumor mutation score should consider immunotherapy as initial treatment.


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City of Hope physician-scientist and his colleagues are looking for ways to provide cancer patients with options that yield better outcomes and are more cost-effective.