Molecular and Cellular Biology of Cancer In the News

Drs. Sampath and Riggs | City of Hope

Sampath Rangasamy, Ph.D., a researcher at City of Hope affiliate TGen, has spent his whole life researching type 1 diabetes, a personal battle since he himself suffers from the disease.


Recently a team of researchers led by City of Hope scientists identified a new potential target to keep the immune system stable and islet beta cells healthy, in an effort to keep type 1 diabetes at bay.

Researcher Li Li | City of Hope

As a Ph.D. candidate at City of Hope, Li Li's work with Alexander disease may also shed new light on similar neurodegenerative conditions such as Alzheimer’s, Parkinson’s and amyotrophic lateral sclerosis.

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A City of Hope researcher has developed a stem cell model to assess possible treatments for a rare nervous system disorder that is in the same disease group as Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (ALS). The finding takes scientists one step closer to finding a way to slow or treat Alzheimer’s disease and other neurodegenerative disorders.

breakthroughs - islet cells

Many people struggle with both diabetes and cancer at the same time — none of this is random or coincidental. Rather, it's clear that, from biology to risk factors to treatment options, cancer and diabetes are intimately related in many ways.

Board of Governors - Rossi

In an effort to improve options for those with liver cancer, a group of researchers have identified a way of potentially treating a broad range of liver diseases and perhaps even other types of cancer.


In an effort to understand cancer on a cellular level, a team of City of Hope researchers have been examining DNA deletions and their role in the disease.

breakthroughs - arthur riggs

Every so often, as City of Hope’s Arthur Riggs, Ph.D., knows well, “forgotten” work can provide groundbreaking insight for new research years later.

Center for Gene Therapy - Kevin Morris

City of Hope researchers have found a link between a type of ancient RNA and a tumor suppressing gene.

Student intern Ben Nittayo | City of Hope

Students spent 10 weeks this summer at the Eugene and Ruth Roberts Summer Student Academy, designed to give hardworking students the opportunity to learn about science by working in a laboratory setting.

researcher in the lab

A collaboration with The Jackson Laboratory expands access to leading-edge research capabilities to find new treatments for life-threatening diseases.

Dr. Yamaguchi

City of Hope’s rich history is filled with stories of celebrated researchers who helped shape the course of modern medicine. Yoko Fujita-Yamaguchi, Ph.D., professor emeritus in the Diabetes & Metabolism Research Institute at City of Hope, has written a book in Japanese that delves into the contributions of Japanese-American scientists at City of Hope.


An international team of researchers led by City of Hope’s Defu Zeng believe they may have found a way to prevent graft-versus host disease following stem cell transplants without sacrificing the transplants’ ability to fight leukemia and lymphoma.

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World-renowned diabetes researcher Arthur D. Riggs, Ph.D., director of the Diabetes & Metabolism Research Institute of City of Hope and director emeritus of Beckman Research Institute of City of Hope, has been named the Samuel Rahbar Chair in Diabetes & Drug Discovery, which honors the life and legacy of the late renowned scientist.

breakthroughs - world diabetes day

Arthur Riggs, Ph.D., the Samuel Rahbar Chair in Diabetes & Drug Discovery and director of the Diabetes & Metabolism Research Institute at City of Hope, is rounding third in his quest for a cure for type 1 diabetes. Now, thanks to a new $50 million funding program led by the Wanek family, he is only picking up the pace.

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Debbie C. Thurmond, Ph.D., a professor in City of Hope’s Diabetes and Metabolism Research Institute and founding chair of the Department of Molecular and Cellular Endocrinology, has been named the Ruth B. & Robert K. Lanman Chair in Gene Regulation and Drug Discovery Research.

breakthroughs - arthur riggs legacy

City of Hope — widely known as a center for cancer care and research — is also the home of one of the most influential diabetes research programs in the world.

Wanek Project - Bart Roep

Diabetes affects over 422 million people worldwide according to the World Health Organization, but no two patients are alike. So in 2017 and beyond, treatments will increasingly make use of precision medicine to personalize treatment options. At City of Hope, researchers are combining the forces of a transformative gift with new resources to speed these treatments to patients.


Science doesn’t always start in the lab. Sometimes collaborations come together over cocktails in Costa Rica. This is how City of Hope cancer biologist Mei Kong Ph.D., and Caltech neuroscientist Viviana Gradinaru, Ph.D., started a project that could change the approach to killing cancerous tumors.


Many know Botox as a trendy way to get rid of wrinkles, but the popular drug - made from botulinum neurotoxin (BoNT) - can do more than just fill lines. However, in a controlled dose and purified form, the toxin can be used for therapeutic purposes, helping treat a variety of diseases.