Key Publications

Past Five Years

C.W. Chen, R. Koche, A. Sinha, A. Deshpande, N. Zhu, R. Eng, J. Doench, H. Xu, S. Chu, J. Qi, X. Wang, C. Delaney, K.M. Bernt, D.E. Root, W.C. Hahn, J.E. Bradner, S.A. Armstrong. DOT1L Inhibits SIRT1-mediated Epigenetic Silencing to Maintain Leukemic Gene Expression in MLL-rearranged Leukemia. Nature Medicine. 2015; 21; 335-343.

C.W. Chen, S.A. Armstrong. Targeting DOT1L and HOX Gene Expression in MLL-rearranged Leukemia and Beyond. Experimental Hematology. 2015; 43(8); 673-684.

A.J. Deshpande, A.A. Deshpande, A.U. Sinha, L. Chen, J. Chang, A. Cihan, M. Fazio, C.W. Chen, N. Zhu, R. Koche, L. Dzhekieva, G. Ibáñez, S. Dias, D. Banka, A. Krivtsov, M. Luo, R.G. Roeder, J.E. Bradner, K.M. Bernt, S.A. Armstrong. AF10 Regulates Progressive H3K79 Methylation and Hox Gene Expression in Diverse AML Subtypes. Cancer Cell. 2014; 26(6); 896-908.

S.F. Cai, C.W. Chen, S.A. Armstrong. Drugging Chromatin in Cancer: Recent Advances and Novel Approaches. Molecular Cell. 2015; 60(4):561-70.

H Xu, D.G. Valerio, M.E. Eisold, A. Sinha, R.P. Koche, W. Hu, C.W. Chen, S.H. Chu, G.L. Brien, J.J. Hsieh, P. Ernst, S.A. Armstrong. NUP98-fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis. Cancer Cell. 2016; 30(6):863-878.

M.W. Kühn, E. Song, Z. Feng,  A. Sinha,  C.W. Chen,  A.J. Deshpande,  M. Cusan,  N. Farnoud,  A. Mupo,  C. Grove,  R. Koche,  J.E. Bradner,  E. de Stanchina,  G.S. Vassiliou,  T. Hoshii,  S.A. Armstrong.  Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia. Cancer Discovery. 2016; 6(10):1166-1181.

N. Zhu, M. Chen, R. Eng, J. DeJong, A.U. Sinha, N.F. Rahnamay, R. Koche, F. Al-Shahrour, J.C. Minehart, C.W. Chen, A.J. Deshpande, H. Xu, S.H. Chu, B.L. Ebert, R.G. Roeder, S.A. Armstrong. MLL-AF9- and HOXA9-mediated Acute Myeloid Leukemia Stem Cell Self-renewal Requires JMJD1C.  Journal of Clinical Investigation. 2016; 126(3):997-1011.

S.C.W. Lee, H. Dvinge, E. Kim, H. Cho, J.B Micol, Y.R. Chung, B.H. Durham, A. Yoshimi, Y.J. Kim, M. Thomas, C. Lobry, C.W. Chen, A. Pastore, J. Taylor, X. Wang, A. Krivtsov, S.A. Armstrong, J. Palacino, S. Buonamici, P.G. Smith, R.K. Bradley, O. Abdel-Wahab. Modulation of Splicing Catalysis for Therapeutic Targeting of Leukemias with Spliceosomal Mutations. Nature Medicine. 2016; 22(6):672-8.

D.G. Valerio, H. Xu, C.W. Chen, T. Hoshii, M.E. Eisold, C. Delaney, M. Cusan, A.J. Deshpande, C.H. Huang, A. Lujambio, Y.G. Zheng, J. Zuber, T.K. Pandita, S.W. Lowe, S.A. Armstrong. Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis. Cancer Research. 2017; 77(7):1753-1762.

S.P. Wang, Z. Tang, C.W. Chen, M. Shimada, R.P. Koche, L.H. Wang, T. Nakadai, A. Chramiec, A.V. Krivtsov, S.A. Armstrong, R.G. Roeder. A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription. Molecular Cell. 2017; 67(2):308-321.