Integrating both computer and laboratory studies, the Kaddis Lab is investigating important correlations between characteristics of the pancreas — home to the islet cells that produce insulin — and the onset, effect and outcomes of type 1 diabetes. Recent studies focus on samples of pancreata from nPOD. We are exploring the data that emerges for clues about the interactions among the structure and biochemistry of the organ, lifestyle and other external factors, and the causes and effects of disease.