The Huss Lab

The Huss Lab is creating new knowledge about the metabolism of muscles. Muscle accounts for 40 percent of body mass and approximately 30 percent of resting metabolism in adults. Meanwhile, the power of regular physical activity to improve health, control blood sugar and potentially overcome type 2 diabetes is well-known. The insights we gain into muscle metabolism could lead to treatments that mimic these benefits of long-term exercise.
We study the action of a special class of messenger proteins that interact with receptors in the cell nucleus. With better understanding of these biochemical pathways and how they regulate the activity of muscle tissue, we may learn how to activate them most effectively. Ultimately, this work could produce new therapies that halt — or even prevent — obesity, diabetes, cancer and the muscle loss that can come with advanced age or disease.