• A 2016 paper in the journal Nature examined metastasis and how cancer cells survive to reach distant organs after they detach from the extracellular matrix. Providing the first evidence from live cells for a mechanism that had long been hypothesized, Dr. Jiang and colleagues showed that a novel cytosol-to-mitochondria citrate transport system mitigates the mitochondrial oxidative stress in the detached cancer cell, as regulated with the IDH1 pathway.