Molecular and Cellular Endocrinology Recent Publications

Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets. Veluthakal R, Chepurny OG, Leech CA, Schwede F, Holz GG, Thurmond DC. Diabetes. 2018 Jul 9. [Epub ahead of print]
 
Novel approaches to restore beta cell function in prediabetes and type 2 diabetes. Salunkhe VA, Veluthakal R, Kahn SE, Thurmond DC. Diabetologia. 2018 Sep;61(9):1895-1901. Epub 2018 Jun 8.
 
CARM1 suppresses de novo serine synthesis by promoting PKM2 activity. Abeywardana T, Oh M, Jiang L, Yang Y, Kong M, Song J, Yang Y. J Biol Chem. 2018 Aug 21. [Epub ahead of print]
 
Conserved transcriptional activity and ligand responsiveness of avian PPARs: potential role in regulating lipid metabolism in migratory birds. Hamilton A, Ly J, Robinson JR, Corder KR, DeMoranville KJ, Schaeffer PJ, Huss JM. Gen Comp Endocrinol. 2018 Aug 13. pii: S0016-6480(18)30115-1. [Epub ahead of print]
 
Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation. Wang QA, Song A, Chen W, Schwalie PC, Zhang F, Vishvanath L, Jiang L, Ye R, Shao M, Tao C, Gupta RK, Deplancke B, Scherer PE. Cell Metab. 2018 Aug 7;28(2):282-288.e3. Epub 2018 Jun 14.
 
Exocytosis Protein DOC2B as a Biomarker of Type 1 Diabetes. Aslamy A, Oh E, Ahn M, Moin ASM, Chang M, Duncan M, Hacker-Stratton J, El-Shahawy M, Kandeel F, DiMeglio LA, Thurmond DC. J Clin Endocrinol Metab. 2018 May 1;103(5):1966-1976.
 
Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function. Aslamy A, Oh E, Olson EM, Zhang J, Ahn M, Moin ASM, Tunduguru R, Salunkhe VA, Veluthakal R, Thurmond DC. Diabetes. 2018 Jul;67(7):1332-1344. Epub 2018 Apr 16
 
 
Depletion of the membrane-fusion regulator Munc18c attenuates caerulein hyperstimulation-induced pancreatitis. Dolai S, Liang T, Orabi AI, Xie L, Holmyard D, Javed TA, Fernandez NA, Xie H, Cattral MS, Thurmond DC, Thorn P, Gaisano HY. J Biol Chem. 2018 Feb 16;293(7):2510-2522. Epub 2017 Dec 28.
 
t-Darpp Activates IGF-1R Signaling to Regulate Glucose Metabolism in Trastuzumab-Resistant Breast Cancer Cells. Lenz G, Hamilton A, Geng S, Hong T, Kalkum M, Momand J, Kane SE, Huss JM. Clin Cancer Res. 2018 Mar 1;24(5):1216-1226. doi: 10.1158/1078-0432.CCR-17-0824. Epub 2017 Nov 27.
 
Promoting Glucose Transporter-4 Vesicle Trafficking along Cytoskeletal Tracks: PAK-Ing Them Out. Tunduguru R, Thurmond DC. Front Endocrinol (Lausanne). 2017 Nov 20;8:329. eCollection 2017.
 
The actin-related p41ARC subunit contributes to p21-activated kinase-1 (PAK1)-mediated glucose uptake into skeletal muscle cells. Tunduguru R, Zhang J, Aslamy A, Salunkhe VA, Brozinick JT, Elmendorf JS, Thurmond DC. J Biol Chem. 2017 Nov 17;292(46):19034-19043. Epub 2017 Sep 25.
 
Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis. Simcox J, Geoghegan G, Maschek JA, Bensard CL, Pasquali M, Miao R, Lee S, Jiang L, Huck I, Kershaw EE, Donato AJ, Apte U, Longo N, Rutter J, Schreiber R, Zechner R, Cox J, Villanueva CJ. Cell Metab. 2017 Sep 5;26(3):509-522.e6.
 
Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. Schell JC, Wisidagama DR, Bensard C, Zhao H, Wei P, Tanner J, Flores A, Mohlman J, Sorensen LK, Earl CS, Olson KA, Miao R, Waller TC, Delker D, Kanth P, Jiang L, DeBerardinis RJ, Bronner MP, Li DY, Cox JE, Christofk HR, Lowry WE, Thummel CS, Rutter J. Nat Cell Biol. 2017 Sep;19(9):1027-1036. Epub 2017 Aug 14.
 
Short-Term Versus Long-Term Effects of Adipocyte Toll-Like Receptor 4 Activation on Insulin Resistance in Male Mice. Tao C, Holland WL, Wang QA, Shao M, Jia L, Sun K, Lin X, Kuo YC, Johnson JA, Gordillo R, Elmquist JK, Scherer PE. Endocrinology. 2017 May 1;158(5):1260-1270.