Hematologic Malignancies and Stem Cell Transplantation Institute
Led by Stephen J. Forman, M.D., Francis & Kathleen McNamara Distinguished Chair in Hematology and Hematopoietic Cell Transplantation, our dedicated, multidisciplinary team combines innovative laboratory research discoveries to develop novel clinical treatments that will improve outcomes for patients.
The mission of the institute is to bring pioneering research discoveries in hematological malignancies and stem cell transplantation to early-phase clinical trials of potentially practice-changing therapies.
The vision of the institute is to become one of the foremost research and clinical treatment centers for hematological malignancies and stem cell transplantation, making the best available therapies accessible to all patients.
The institute is a matrix comprised of seven centers, each with a focus on a particular disease or treatment modality. Because the specific diseases can frequently be treated by multiple modalities, there is deliberate cross-pollination between the centers, with most faculty collaborating in research involving two or more centers.
City of Hope has a long history of specializing in lymphoma, which includes some of the most common (Hodgkin, diffuse large B cell, follicular and small lymphocytic lymphomas) and the rarest (T cell non-Hodgkin, marginal and mantle cell lymhoma, Burkitt’s and hairy cell lymphomas) of hematological malignancies. Led by Director Larry Kwak, M.D., Ph.D., and Associate Director Robert W. Chen, M.D., the Toni Stephenson Lymphoma Center is committed to eliminating this disease by developing immune-based, nontransplant therapies, many of which have already shown promise in City of Hope’s laboratories.
City of Hope's Center for CAR-T Cell Therapy is finding new ways to harness the immune system to fight cancer by re-engineering patients' T lymphocytes to target and eradicate malignancy. Led by Stephen Forman, M.D. and Christine Brown, Ph.D., the researchers are discovering and applying new immunotherapies by genetically reprogramming T cells with chimeric antigen receptors (CARs) that tailor patients’ immune responses to their specific cancers. The Center for CAR-T Cell Therapy continues to build upon successful CAR-T cell treatment platforms for hematologic cancers, an area that has been making headlines recently with new FDA approvals of CAR-T cell therapies. The team is developing and clinically testing CAR-based treatments for leukemia, lymphoma, myeloma, as well as for solid tumors including brain, breast, prostate, liver and ovarian.
CENTER FOR GENE THERAPY
The goal of the Judy and Bernard Briskin Center for Multiple Myeloma Research, directed by Amrita Krishnan, M.D., is to make multiple myeloma, and the related light chain amyloidosis, manageable nonlethal diseases. Center researchers are achieving this goal by aggressively pursuing and encouraging new research, developing improved treatments, and collaborating with myeloma and amyloid experts nationally and internationally.
Led by Guido Marcucci, M.D., and Anthony Stein, M.D., the Gehr Family Center for Leukemia Research at City of Hope seeks to further expand and broaden our world-renowned work in the research and treatment of acute myeloid leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, myelodysplastic syndrome and myeloproliferative neoplasms. The center focuses on discovering new actionable molecular targets, developing novel targeted therapies and implementing these therapies in precision-medicine approaches.
CENTER FOR STEM CELL TRANSPLANTATION
The Center for Stem Cell Transplantation uses leading-edge research to advance hematopoietic stem cell transplant methods. Our dedicated team, directed by Ryotaro Nakamura, M.D. and David Snyder, M.D., is working to reduce treatment toxicity and improve patient outcomes. Our researchers have access to a large transplant patient population, rich historical data and a clinical department with a reputation for outstanding transplant outcomes for the past 12 consecutive years. Center research focuses on donor types, treatment complication such as graft-vs-host disease, cytomeglovirus vaccination and regimens designed to reduce the risk of relapse.
CENTER FOR SURVIVORSHIP AND OUTCOMES
Directed by Saro Armenian, D.O., M.P.H., the goal of the Center for Survivorship and Outcomes is to improve the overall quality of life for survivors of hematological (blood, bone marrow and lymph node) cancers. The center incorporates novel real-time data collection on health outcomes during and decades after completion of therapy, allowing us to understand the short-term and long-term health challenges faced by our survivors. This information is then used to inform clinicians on novel treatment strategies, risk stratification and long-term monitoring of our patients.