Program

Wednesday, April 10, 2019

8 A.M. | Registration and Breakfast
 
9:30 A.M. | Plenary Lecture
 
BRS3 (Bombesin Receptor Subtype-3) and the regulation of energy homeostasis
Marc Reitman, MD, PhD, NIDDK, National Institutes of Health
 
10 A.M. | Refreshment Break
 
10:15 A.M. | Session 1: Diabetes Complications
 
Epidemiologic insights into the development of type 1 diabetes complications
Trevor Orchard, MD, University of Pittsburgh Schools of the Health Sciences
 
Promoters and protectors in diabetic complications
Catherine Godson, PhD, University College Dublin
 
Diabetes and atherosclerosis: Insights into mechanisms of vascular inflammation
Karin Bornfeldt, PhD, University of Washington
 
Diabetic nephropathy: New insights from metabolomics
Kumar Sharma, MD, UT Health San Antonio
 
12:15 P.M. | Lunch Break
 
12:45 P.M. | Session 2: Genetics and Epigenetics of Diabetes
 
Chromatin remodeling and lncRNAs in diabetic endothelial dysfunction
Zhen Chen, PhD, City of Hope
 
LncRNAs: New markers of human metabolic and cardiometabolic disorders
Muredach Reilly, MBBCh, Columbia University
 
Epigenetic clock analysis of diet, exercise, education, and lifestyle factors
Steve Horvath, PhD, University of California, Los Angeles
 
Epigenetics and diabetic complications
Sam El-Osta, PhD, Monash University
 
2:45 P.M. | Refreshment Break
 
3:05 P.M. | Plenary Lecture
 
Metabolic flexibility in health and disease
Bret Goodpaster, PhD, Translational Research Institute for Metabolism and Diabetes
 
3:50 P.M.  | Debate: GWAS Studies Should Continue as a Valuable Tool to Explore Diabetes Pathogenesis
 
Pro: Does GWAS contribute much to type 2 diabetes?
Jose Florez, MD, PhD, Massachusetts General Hospital
 
Con: Are more GWAS needed to provide understanding of diabetes risk, pathogenic mechanisms, intervention and treatment?
Stephen Rich, PhD, University of Virginia School of Medicine
 
6 P.M. | Presentation of Awards and Dinner Lecture
 
Can human beta cells be induced to regenerate in people with diabetes?
Andrew Stewart, MD, Icahn School of Medicine at Mount Sinai
 

Thursday, April 11, 2019

7 A.M. | Registration and Breakfast
 
8 A.M. | Session 1: Novel Treatments for Diabetes
 
Lifestyle in the context of precision diabetes medicine
Paul Franks, PhD, Lund University Diabetes Centre
 
New approaches beyond genetics: Towards precision medicine in diabetes
Leif Groop, MD, PhD, Lund University Diabetes Centre
 
Metabolomics of microbiota: Molecules that influence glucose metabolism
Louis Cohen, MD, Icahn School of Medicine at Mount Sinai
 
Therapeutic effects of fecal transplantation in human type 1 and type 2 diabetes
Max Nieuwdorp, MD, PhD, University of Amsterdam
 
10 A.M. | Refreshment Break
 
10:20 A.M. | Session 2: Pancreas on a Chip
 
Microfluid perfusion systems for secretion fingerprint analysis of pancreatic islets
Maryam Tabrizian, PhD, McGill University
 
Organ on a chip for diabetes research
Aline Zbinden, PhD, Eberhard Karls University Tübingen
 
11:30 A.M. | Lunch Break
 
1 P.M. | Session 3: Heterogeneity and Plasticity of Islet Cells
 
Heterogeneity of the pancreatic islet cells
Lori Sussel, PhD, Barbara Davis Center for Diabetes
 
Lineage plasticity within the adult human pancreas
Jake Kushner, MD, Baylor College of Medicine
 
2:10 P.M. | Refreshment Break
 
2:30 P.M. | Session 4: “Smart” Insulins
 
Minimally invasive control of blood glucose using a light activated insulin depot
Simon Friedman, PhD, University of Missouri, Kansas City
 
Heat stable single chain insulin
Michael Weiss, MD, PhD, Indiana University School of Medicine 
 
3:40 P.M. | Refreshment Break
 
4:00 P.M. | Session 5: Bariatric Surgery vs. Lifestyle Intervention
 
The contribution of gut nutrient sensing in bariatric surgery and metformin therapy
Tony Lam, PhD, University of Toronto
 
Mechanisms of diabetes remission after metabolic surgery
David Cummings, MD, University of Washington
 
Reinventing bariatric surgery
Randy Seeley, PhD, University of Michigan
 
Hypoglycemia after bariatric surgery
Mary-Elizabeth Patti, MD, Joslin Diabetes Center 
 
6 P.M. | Poster Session and Reception
 

Friday, April 12, 2019

7 A.M. | Registration and Breakfast
 
8 A.M. | Rachmiel Levine Award Lecture
 
Beta-cell dysfunction in type 2 diabetes: A tale of two ages?
Steven Kahn, MB ChB, VA Puget Sound Health Care System and University of Washington
 
8:45 A.M. | Session 1: Protecting the Beta Cell
 
Strategies for beta cell proliferation/beta cell survival
Rupangi Vasavada, PhD, City of Hope
 
Amino acid regulation of endocrine cell growth
Danielle Dean, PhD, Vanderbilt University Medical Center
 
Effect of ER stress on endocrine cell proliferation
Laura Alonso, MD, University of Massachusetts Medical School
 
TXNIP and new therapies for T1D
Anath Shalev, MD, University of Alabama at Birmingham 
 
10:45 A.M. | Refreshment Break
 
11:05 A.M. | Session 2: Progenitor Cells
 
Understanding human fetal pancreas development using subpopulation sorting, RNA and single cell profiling
Raphael Scharfmann, PhD, INSERM-Institute Cochin
 
Pluripotent stem cell derived beta-like cells for diabetes cellular therapy
George Harb, PhD, Semma Therapeutics
 
MAFB regulates critical aspects of human islet cell development
Matthias Hebrok, PhD, University of California, San Francisco
 
Development of immune invisible beta cell as a therapy for T1D through genetic modification of hESCs
Yang Xu, PhD, University of California, San Diego 
 
1:05 P.M. | Lunch Break
 
2:30 P.M. | Session 3: Immunomodulation for T1D
 
Immunotherapy in T1D
Colin Dayan, MBBS, PhD, Cardiff University
 
Dendritic cells for immunomodulation in T1D
Bart Roep, PhD, City of Hope
 
ATG preserves beta cell function in early T1D
Michael Haller, MD, University of Florida
 
Alpha methyldopa and autoimmune diabetes
Aaron Michels, MD, University of Colorado Anschutz Medical Campus 
 
4:30 P.M. | Refreshment Break
 
4:50 P.M. | Session 4: Immunometabolism
 
Immunometabolism, epigenetics and trained immunity
Rinke Stienstra, PhD, Radboud University Medical Centre
 
STAT 3 in diabetes
Hua Yu, PhD, City of Hope
 
Obesity-induced cognitive decline requires reactive microglia
Elise Cope, PhD, Princeton University
 
Immunity-metabolism cross talk
Laszlo Nagy, MD, PhD, Johns Hopkins University School of Medicine


Saturday, April 13, 2019

7 A.M. | Registration and Breakfast
 
8 A.M. | Arthur Riggs Award Lecture
 
TBD
Gerald Shulman, MD, PhD, Yale University School of Medicine
 
8:45 A.M. | Session 1: Interface of Diabetes with Cancer
 
Cancer and diabetes metabolism
Gregory Steinberg, PhD, McMaster University
 
Outcomes of immune therapy
Jeff Bluestone, PhD, University of California, San Francisco
 
The role of obesity-related risk factors in cancer – Evidence from genetic studies
Mattias Johansson, PhD, International Agency for Research on Cancer
 
Tet2 phosphorylation in cancer and diabetes
Yujiang Shi, PhD, Harvard Medical School 
 
10:45 A.M. | Refreshment Break
 
11:05 A.M. | Session: New Insights in Diabetes
 
Loss of endocrine and exocrine function and mass in T1D
Martha Campbell-Thompson, DVM, PhD, University of Florida
 
Quantitative MRI of the pancreas in T1D: Moving beyond volume
John Virostko, PhD, The University of Texas at Austin
 
Pathogenesis of insulin resistance in humans: Lessons from study of the liver lipidome in common types of NAFLDs
Hannele Yki-Järvinen, MD, University of Helsinki
 
Does the immune response against beta cells burnout with time?
Richard Oram, PhD, University of Exeter Medical School