Wednesday, April 10, 2019

8 a.m. | Registration and Breakfast
9:15 a.m. | Plenary Lecture
BRS3 (Bombesin Receptor Subtype-3) and the regulation of energy homeostasis
Marc Reitman, M.D., Ph.D., NIDDK, National Institutes of Health
10 a.m. | Refreshment Break
10:15 a.m. | Session 1: Diabetes Complications
Scientific Achievement Award Presentation
Sooyeon Lee, Ph.D., Stanford University
Epidemiologic insights into the development of type 1 diabetes complications
Trevor Orchard, M.D., University of Pittsburgh
Promoters and protectors in diabetic complications
Catherine Godson, Ph.D., University College Dublin
Diabetes and atherosclerosis: Insights into mechanisms of vascular inflammation
Karin Bornfeldt, Ph.D., University of Washington
Diabetic nephropathy: New insights from metabolomics
Kumar Sharma, M.D., University of Texas Health Science Center at San Antonio
12:25 p.m. | Lunch Break
1:00 p.m. | Session 2: Genetics and Epigenetics of Diabetes
Chromatin remodeling and lncRNAs in diabetic endothelial dysfunction
Zhen Chen, Ph.D., City of Hope
LncRNAs: New markers of human metabolic and cardiometabolic disorders
Muredach Reilly, MBBCh, Columbia University
Epigenetic clock analysis of diet, exercise, education, and lifestyle factors
Steve Horvath, Ph.D., University of California Los Angeles
Epigenetics and diabetic complications
Sam El-Osta, Ph.D., Monash University
3:00 p.m. | Refreshment Break and Visit Exhibits
3:15 p.m. | Plenary Lecture
Metabolic flexibility in obesity and diabetes
Bret Goodpaster, Ph.D., AdventHealth Translational Research Institute for Metabolism and Diabetes
4:00 p.m.  | Debate: GWAS Studies Should Continue as a Valuable Tool to Explore Diabetes Pathogenesis
Pro: Does GWAS contribute much to type 2 diabetes?
Jose Florez, M.D., Ph.D., Massachusetts General Hospital
Con: Are more GWAS needed to provide understanding of diabetes risk, pathogenic mechanisms, intervention and treatment?
Stephen Rich, Ph.D., University of Virginia School of Medicine
6 p.m. | Presentation of Awards and Dinner Lecture
Can human beta cells be induced to regenerate in people with diabetes?
Andrew Stewart, M.D., Icahn School of Medicine at Mount Sinai

Thursday, April 11, 2019

7 a.m. | Registration and Breakfast
8 a.m. | Session 1: Novel Treatments for Diabetes
Lifestyle in the context of precision diabetes medicine
Paul Franks, Ph.D., Lund University Diabetes Centre
New approaches beyond genetics: Towards precision medicine in diabetes
Leif Groop, M.D., Ph.D., Institute for Molecular Medicine Finland (FIMM), HiLIFE, and Lund University
Metabolomics of microbiota: Molecules that influence glucose metabolism
Louis Cohen, M.D., Icahn School of Medicine at Mount Sinai
Therapeutic effects of fecal transplantation in human type 1 and type 2 diabetes
Max Nieuwdorp, M.D., Ph.D., University of Amsterdam
10 a.m. | Refreshment Break and Visit Exhibits
10:15 a.m. | Session 2: Pancreas on a Chip
Microfluidic perfusion systems for secretory fingerprint analysis of human pancreatic islets
Maryam Tabrizian, Ph.D., McGill University
Organ on a chip for diabetes research
Aline Zbinden, Ph.D., M.Sc., University of Tübingen
11:25 a.m. | Lunch Break (Sponsored by KRONUS, Inc.)
1 p.m. | Session 3: Heterogeneity and Plasticity of Islet Cells
Scientific Achievement Award Presentation
Jose Ortiz, City of Hope
Heterogeneity of the pancreatic islet cells
Lori Sussel, Ph.D., Barbara Davis Center for Diabetes
Lineage plasticity within the adult human pancreas
Jake Kushner, M.D., Baylor College of Medicine
2:20 p.m. | Refreshment Break and Visit Exhibits
2:35 p.m. | Session 4: “Smart” Insulins
Minimally invasive control of blood glucose using a light activated insulin depot
Simon Friedman, Ph.D., University of Missouri, Kansas City
Heat stable single chain insulin
Michael Weiss, M.D., Ph.D., Indiana University School of Medicine 
3:45 p.m. | Refreshment Break and Visit Exhibits
4 p.m. | Session 5: Bariatric Surgery vs. Lifestyle Intervention
The contribution of gut nutrient sensing in bariatric surgery and metformin therapy
Tony Lam, Ph.D., University of Toronto
Mechanisms of diabetes remission after metabolic surgery
David Cummings, M.D., University of Washington
Reinventing bariatric surgery
Randy Seeley, Ph.D., University of Michigan
Hypoglycemia after bariatric surgery
Mary-Elizabeth Patti, M.D., Joslin Diabetes Center 
6 p.m. | Poster Session and Reception

Friday, April 12, 2019

7 a.m. | Registration and Breakfast
8 a.m. | Rachmiel Levine Award Lecture
Beta-cell dysfunction in type 2 diabetes: A tale of two ages?
Steven Kahn, M.B., Ch.B., VA Puget Sound Health Care System and University of Washington
8:45 a.m. | Session 1: Protecting the Beta Cell
Strategies for beta cell proliferation/beta cell survival
Rupangi Vasavada, Ph.D., City of Hope
Amino acid regulation of endocrine cell proliferation and function
Danielle Dean, Ph.D., Vanderbilt University Medical Center
The sweet spot: ER stress and beta cell proliferation
Laura Alonso, M.D., University of Massachusetts Medical School
TXNIP and new therapies for T1D
Anath Shalev, M.D., University of Alabama at Birmingham 
10:45 a.m. | Refreshment Break and Visit Exhibits
11:00 a.m. | Session 2: Progenitor Cells
Scientific Achievement Award Presentation
Gal Lenz, Ph.D., City of Hope
Understanding human fetal pancreas development using subpopulation sorting, RNA and single cell profiling
Raphael Scharfmann, Ph.D., INSERM-Institute Cochin
Pluripotent stem cell derived beta-like cells for diabetes cellular therapy
George Harb, Ph.D., Semma Therapeutics
MAFB regulates critical aspects of human islet cell development
Matthias Hebrok, Ph.D., University of California, San Francisco
Development of immune invisible beta cell as a therapy for T1D through genetic modification of hESCs
Yang Xu, Ph.D., University of California, San Diego 
1:10 p.m. | Lunch Break
2:30 p.m. | Session 3: Immunomodulation for T1D
Immunotherapy in T1D
Colin Dayan, Ph.D., Cardiff University
Dendritic cells for immunomodulation in T1D
Bart Roep, Ph.D., City of Hope
ATG preserves beta cell function in early T1D
Michael Haller, M.D., University of Florida
Methyldopa as a disease modifying therapy for type 1 diabetes
Aaron Michels, M.D., University of Colorado Anschutz Medical Campus 
4:30 p.m. | Refreshment Break and Visit Exhibits
4:45 p.m. | Session 4: Immunometabolism
Immunometabolism, epigenetics and trained immunity
Rinke Stienstra, Ph.D., Radboud University Medical Centre
STAT3 in diabetes
Hua Yu, Ph.D., City of Hope
Obesity-induced cognitive decline requires reactive microglia
Elise Cope, Ph.D., Princeton University
System-level analysis to identify macrophage-specific mechanisms controlling skeletal muscle repair and metabolism
Laszlo Nagy, M.D., Ph.D., Johns Hopkins All Children's Hospital

Saturday, April 13, 2019

7 a.m. | Registration and Breakfast
8 a.m. | Arthur Riggs Award Lecture
The new biology of type 2 diabetes
Gerald Shulman, M.D., Ph.D., Yale University School of Medicine
8:45 a.m. | Session 1: Interface of Diabetes with Cancer
Targeting mitochondria and lipids in cancer
Gregory Steinberg, Ph.D., McMaster University
Outcomes of immune therapy
Jeff Bluestone, Ph.D., University of California, San Francisco
The role of obesity-related risk factors in cancer – Evidence from genetic studies
Mattias Johansson, Ph.D., International Agency for Research on Cancer
Tet2 phosphorylation in cancer and diabetes
Yujiang Shi, Ph.D., Harvard Medical School 
10:45 a.m. | Refreshment Break and Visit Exhibits
11:00 a.m. | Session 2: New Insights in Diabetes
Loss of endocrine and exocrine function and mass in T1D
Martha Campbell-Thompson, D.V.M., Ph.D., University of Florida
Quantitative MRI of the pancreas in T1D: Moving beyond volume
John Virostko, Ph.D., The University of Texas at Austin
Pathogenesis of insulin resistance in humans: Lessons from study of the liver lipidome in common types of NAFLDs
Hannele Yki-Järvinen, M.D., Ph.D., University of Helsinki
Does the immune response against beta cells burnout with time?
Richard Oram, M.D., Ph.D., University of Exeter Medical School