Phase I Brain Tumors CAR-T Cell Clinical Trial

Our brain tumor team is currently enrolling patients with recurrent brain tumors for a new Phase I clinical trial that harnesses CAR-T immunotherapy to fight advanced brain cancers.

 

You can learn more about this clinical trial online at ClinicalTrials.gov.
 

IRB #13384: Phase I Study of Cellular Immunotherapy Using Central Memory Enriched T Cells Lentivirally Transduced to Express an IL13Rα2-Specific, Hinge-Optimized, 41BB-Costimulatory Chimeric Antigen Receptor and a Truncated CD19 for Patients with Recurrent/Refractory Malignant Glioma

In this ‘first in human’ clinical study, we are evaluating the safety and feasibility of reprogramming a patient’s own immune system to target malignant glioma. For this study, white blood cells known as T cells are isolated and engineered to express a protein of novel design called a chimeric antigen receptor (CAR). This CAR instructs the T cells to recognize and kill target cells that express IL13Rα2, a receptor readily detected on the majority of malignant gliomas, but not on normal brain tissue.

Research participants will be enrolled on one of two treatment arms based on surgical need: 1) tumor resection or 2) tumor biopsy for non-resectable tumors.  At the time of surgery, a catheter system will be placed for local delivery of the reprogrammed T cells at the tumor site.  Following recovery from surgery and cell manufacture, research participants will receive weekly injections of the CAR T cells for 3 weeks, with an option for an additional 3-week treatment course.

Patient Eligibility Requirements:

  • Patient has had a prior, histologically-confirmed diagnosis of a grade III or grade IV glioma.
  • Radiographic evidence of progression/recurrence of the measurable disease more than 12 weeks after the end of radiation therapy.
  • COH clinical pathology to confirm IL13Rα2+ tumor expression by immunohistochemistry.
  • Karnofsky Performance Score ≥60%.
  • Male or female research participants between 18-75 years of age.

If you are interested in learning more about this clinical trial or in referring a patient for enrollment, please call 844-333-HOPE (4673) or email [email protected].  For a summary of this study including the full eligibility criteria, visit City of Hope’s clinical trials website at http://clinicaltrials.coh.org and enter “13384” in the keyword search.