Defu Zeng Lab Publications

Zhang M, Racine JJ, Lin Q, Liu Y, Tang S, Qin Q, Qi T, Riggs AD, Zeng D (2018). MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2329-E2337. doi: 10.1073/pnas.1720169115. Epub 2018 Feb 20.
Zeng D (2018). Newly found arsons ignite the fire of gut GVHD. J Clin Invest. 2018 Mar 1;128(3):897-899. doi: 10.1172/JCI98685. Epub 2018 Jan 29.
Deng R, Hurtz C, Song Q, Yue C, Xiao G, Yu H, Wu X, Muschen M, Forman S, Martin PJ, Zeng D (2017). Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease. Nat Commun. 2017 Oct 17;8(1):978. doi: 10.1038/s41467-017-00880-2.
Zeng D. Bridge between type 1 diabetes in mouse and man. Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):10821-10823. doi: 10.1073/pnas.1715058114. Epub 2017 Oct 2
Ni X, Song Q, Cassady K, Deng R, Jin H, Zhang M, Dong H, Forman S, Martin PJ, Chen YZ, Wang J, Zeng D (2017). PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells. J Clin Invest. 2017 May 1;127(5):1960-1977. doi: 10.1172/JCI91138. Epub 2017 Apr 17.
Jin H, Ni X, Deng R, Song Q, Young J, Cassady K, Zhang M, Forman S, Martin PJ, Liu Q, Zeng D (2016). Antibodies from donor B cells perpetuate cutaneous chronic graft-versus-host disease in mice. Blood. 2016 May 5;127(18):2249-60. doi: 10.1182/blood-2015-09-668145. Epub 2016 Feb 16.
Zhang M, Lin Q, Qi T, Wang T, Chen CC, Riggs AD, Zeng D (2016). Growth factors and medium hyperglycemia induce Sox9+ ductal cell differentiation into β cells in mice with reversal of diabetes. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):650-5. doi: 10.1073/pnas.1524200113. Epub 2016 Jan 5.
Wu L, Li N, Zhang M, Xue SL, Cassady K, Lin Q, Riggs AD, Zeng D (2015). MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15994-9. doi: 10.1073/pnas.1521157112. Epub 2015 Dec 8.
Deng R, Cassady K, Li X, Yao S, Zhang M, Racine J, Lin J, Chen L, Zeng D (2015). B7H1/CD80 interaction augments PD-1-dependent T cell apoptosis and ameliorates graft-versus-host disease. J Immunol. 2015 Jan 15;194(2):560-74. doi: 10.4049/jimmunol.1402157. Epub 2014 Dec 8.
Racine JJ, Zhang M, Wang M, Morales W, Shen C, Zeng D (2015). MHC-mismatched mixed chimerism mediates thymic deletion of cross-reactive autoreactive T cells and prevents insulitis in nonobese diabetic mice. J Immunol. 2015 Jan 1;194(1):407-17. doi: 10.4049/jimmunol.1401584. Epub 2014 Nov 26.
Wang M, Racine J, Zhang M, Wu T, Deng R, Johnston H, Shen C, Siswanto K, Zeng D (2014). MHC-mismatched chimerism is required for induction of transplantation tolerance in autoimmune nonobese diabetic recipients. J Immunol. 2014 Aug 15;193(4):2005-15. doi: 10.4049/jimmunol.1401137. Epub 2014 Jul 7.
Johnston HF, Xu Y, Racine JJ, Cassady K, Ni X, Wu T, Chan A, Forman S, Zeng D (2014). Administration of anti-CD20 mAb is highly effective in preventing but ineffective in treating chronic graft-versus-host disease while preserving strong graft-versus-leukemia effects. Biol Blood Marrow Transplant. 2014 Aug;20(8):1089-103. doi: 10.1016/j.bbmt.2014.04.028. Epub 2014 May 4.
Zeng D (2014). Regulators help new immigrants settle down? Blood. 2014 May 1;123(18):2754-6. doi: 10.1182/blood-2014-03-562173.
He W, Racine JJ, Johnston HF, Li X, Li N, Cassady K, Liu C, Deng R, Martin P, Forman S, Zeng D (2014). Depletion of host CCR7(+) dendritic cells prevented donor T cell tissue tropism in anti-CD3-conditioned recipients. Biol Blood Marrow Transplant. 2014 Jul;20(7):920-8. doi: 10.1016/j.bbmt.2014.03.029. Epub 2014 Mar 30.
Racine JJ, Wang M, Zhang M, Zeng D (2014). Induction of mixed chimerism depletes pre-existing and de novo-developed autoreactive B cells in autoimmune NOD mice. Diabetes. 2014 Jun;63(6):2051-62. doi: 10.2337/db13-1532. Epub 2014 Jan 23