X-ray Crystallography

The X-ray Crystallography Core Facility is one of multiple Shared Resources facilities at Beckman Research Institute of City of Hope.
 
The objectives of the X-Ray Crystallography Core Facility are to:
  1. Provide structural and biophysical information by which to understand, at the atomic level, mechanisms of biological systems
  2. Validate binding sites of lead compounds of therapeutic interest
  3. Facilitate lead discovery through co-crystallization of therapeutic targets and of small-molecule libraries
 
Services provided include:
  • Protein expression and purification
  • Biophysical characterization of macromolecules and of small molecules
  • Crystallization
  • Diffraction quality
  • Data collections
  • Structure determination
 
 
Research reported in this publication includes work performed in the X-ray Crystallography Core and supported by the National Cancer Institute of the National Institutes of Health under award number P30CA33572. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
 
Assessment of authorship will be determined by the level of intellectual input, assay design, and data analysis provided by Core leadership and by staff members for each project, individually, based on NIH authorship guidelines.
 
This core is a Cancer Center Support Grant (CCSG) Sponsored Core.