FEI Vitrobot Mark IV

This fully automated vitrification device for plunge-freezing of aqueous (colloidal) suspensions provides a powerful means for determining the 3D structure of macromolecules and macromolecular complexes in their natural state. Single-particle analysis and EM reconstruction of specimens prepared with the Vitrobot and analyzed by Cryo-EM can partner nicely with X-ray crystallography and NMR spectrometry in determining of molecular structures.