The Gene Editing and Viral Vector Core (GEVVC) serves as a supporting facility for City of Hope’s principal investigators, whose primary interest involves genetic engineering of human and mouse genomes for basic research and therapeutic disease treatment. The missions of the core include:
- Using gene editing techniques to modify the genome of animals, cultured human/mouse cell lines, primary cells, including hematopoietic stem cells and pluripotent stem cells;
- production of infectious lentiviral and retroviral vector for gene delivery into culture cells;
- production of adenoviral vector (AdV) and adeno-associated vector (AAV) for direct gene delivery into animal in vivo or primary cells in vitro.