The Multi-Scale Translational Research (MSTR) Core facilitates research that integrates analyses made at several different scales – populations, individuals, cells and microenvironment, omics, and analytes – to provide greater insight into cancer. Historically, scientists have studied cancer at only one of these scales at a time, focusing on a large epidemiological study, or drug response in an individual, or the effects of a particular DNA mutation, for example. Recently, there has been a push to use computational analysis to integrate data from many scales into multi-scale models of cancer and other subjects. This move complements the Precision Medicine initiative recently launched by the NIH, which calls for the use of multi-scale models and the integration of multi-scale data to improve treatment and care for the individual.
The MSTR Core supports investigators and projects seeking to integrate data at several scales and apply multi-scale modeling techniques. It builds on the large cohorts established by the earlier Population Sciences Survey Core, allowing them to be leveraged for multi-scale studies that incorporate geospatial risk information, images, and cell signaling data in mouse and human tissues, among other data. By making several types of data, especially omics data, available to researchers who ordinarily would not be able to access them, the MSTR Core hopes to encourage more multi-scale and translational research.
Obviously, multi-scale integration of mechanistically linked multi-disciplinary data is a complex undertaking. Multi-scale studies require 1) unique computational and biostatistical expertise, 2) rigorous validation of each biomarker, analyte navigation, and risk measures, and 3) a wide range of multi-disciplinary skills at each level of scale (geospatial modeling and epidemiology, clinical medicine, microenvironment/tissue engineering, cell biology, genetics/genomics, pharmacogenetics). To address these challenges, the MSTR Core offers consultation, grant preparation, multi-scale modeling, and data storage services in support of projects and investigators undertaking translational and multi-scale research.
In addition, a microdissecting scope, a slide scanner, a printer for high-throughput stromal-epithelial interaction studies, and two Sequanomes for genetic admixture studies are available for use in conjunction with Core services. The MSTR Core is staffed by leading experts in a variety of disciplines, all of whom have extensive experience with multi-scale and translational research. Funding for the core is provided by City of Hope’s Cancer Center Support Grant (CCSG), which is funded by the National Cancer Institute and by additional institutional support.
Please see the Services page for more information about our services.
- Please see the Projects page to get a sampling of the projects that have been supported by the MSTR Core. (COMING SOON)