The Hematopoietic Tissue Biorepository (HTB) is a shared resource core facility within Beckman Research Institute of City of Hope. The HTB was established to help further our understanding of all aspects of normal and aberrant hematopoiesis, as well as to better understand cell-based immune therapies, including hematopoietic stem cell transplant and gene modified immune cell therapies. Our primary goal is to support high quality, translational, clinical research on hematological diseases and malignancies by providing biological specimens of interest to all investigators who have an IRB-approved research protocol at City of Hope and other affiliated research institutions.
The HTB banks bone marrow aspirates and peripheral blood mononucleocytes from healthy donors and patients diagnosed with acute and chronic myeloid leukemia, acute and chronic lymphocytic leukemia, myelodysplastic syndrome, myeloproliferative neoplasms, multiple myeloma, lymphoma and sickle cell anemia. We are expanding our services to include banking of microbiome samples, as well as cells expanded from skin biopsies and other normal germline sources such as saliva, urine and buccal cells.
The HTB can provide the investigator with fresh or cryopreserved specimens, or DNA/RNA processed from those specimens. We can also prospectively collect specimens to fulfill specific research needs. The HTB has its own IRB-approved banking protocol to which it strives to consent all patients treated for a hematological disease at City of Hope. It also serves as the biospecimen processing lab for clinical trial protocols requiring such services.
The HTB samples, and associated sample and medical data, are logged into a laboratory information management system known as LabKey, which was specifically designed for the facility and is maintained on a 21CFR Part 11 compliant secure server with access only to HTB staff.
Overall, the HTB has banked close to 35,000 individual specimens and the number is growing daily. Please contact us for more information or to discuss potential projects.