The Pathology Core at City of Hope exists primarily to provide optimally preserved tumors and normal tissue samples to City of Hope researchers. Supported by the Cancer Center Support Grant with funding from the National Cancer Institute, the Pathology Core maintains a bank of several thousand diverse tumor samples. Samples of normal tissue are available as well. All samples are inventoried and tested periodically to ensure quality of morphologic preservation and DNA/RNA integrity. Data is stored and maintained electronically, so that, in most instances, complete follow-up information is available.
Through the Pathology Core, researchers have access to optimally fixed tumor samples, many of which are preserved in more than one type of fixative. Multitissue blocks, containing many types of tumor and normal tissue, are also available, to facilitate retrospective screenings of, for example, new antibodies in immunohistochemistry studies, and new molecular probes associated with in situ hybridization methods.
For a nominal fee researchers may obtain additional assistance and training in the use of these techniques. Consultations with a qualified pathologist and/or molecular biologist are required for users of the core facility.
Researchers wishing to utilize Pathology Core services must register each project they engage in, following the procedures listed below:
Fill out a Tumor Bank Registration Form for each project. This form is required by the National Institutes of Health and must be kept on file with the Pathology Core.
Submit a brief description of the project, including tissue requirements and copy of IRB approval, to Peiguo Chu, M.D., Ph.D., director of Surgical Pathology.
Obtain Department of Pathology approval for all requests using patient clinical material (fresh tissue from the gross room, slides and blocks).
Discuss the project with a staff pathologist to determine the type and amount of tissue needed. In the interest of efficiency, other needs (paraffin sections, clinical information from the surgical pathology report, etc.) should be ascertained, and costs can be discussed at this time.
Research reported in this publication included work performed in the Pathology Core supported by the National Cancer Institute of the National Institutes of Health under award number P30CA33572. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.