City of Hope researchers found that “turning off” the BCL6 protein and using the small molecule ABT-199 eliminated drug resistance in mouse models that had a subtype of B cell acute lymphoblastic leukemia.
Dr. Jianjun Chen was recently named the Simms/Mann Family Foundation Chair in Systems Biology. Chen was recognized with the endowment for his leading-edge cancer research that is founded in personalized, gene-based medicine.
Jianjun Chen, Ph.D., has been named the Simms/Mann Family Foundation Chair in Systems Biology at City of Hope in recognition of his leading-edge research that is helping to build the foundation of personalized, gene-based medicine.
City of Hope, a world-renowned independent research and treatment center for cancer and diabetes, will highlight a variety of basic research and population studies at the annual meeting of the American Association for Cancer Research (AACR) in Chicago’s McCormick Place April 14 to 18.
In a new paper published in the journal Cell, a team of researchers led by City of Hope’s Markus Müschen, M.D., Ph.D., and Gang Xiao, Ph.D., reports on the discovery of a new therapeutic target for these B cell malignancies.
Thanks to research being done by City of Hope's Markus Müschen, M.D., Ph.D., lymphoma patients may soon receive treatments that leverage quality control mechanisms that our own immune systems utilize to fight harmful antibodies.
Acute myeloid leukemia, or AML, is one of the most common and fatal forms of blood-related cancers. Jianjun Chen, Ph.D., a new faculty member at City of Hope, dedicates much of his research program to learning more about the disease.
According to a new article in Nature, a team led by City of Hope’s Markus Müschen, M.D., Ph.D., Chair of the Department of Systems Biology, thinks that sugar uptake and energy supply may play a key role in the relapse of ALL.
The African bull elephant is the largest mammal on the planet, comprised of trillions of cells that should ostensibly be a breeding ground for cancer. But because of an evolutionary anomaly, elephants don’t get cancer, a fact that fascinates Markus Müschen, M.D., Ph.D.
Hailed as one of the best researchers of his generation, Markus Müschen, M.D., Ph.D., has joined City of Hope with the singular goal of wiping out Acute Lymphoblastic Leukemia (ALL), the most common form of cancer in children.
An international team of researchers led by City of Hope’s Markus Müschen, M.D., Ph.D., founding chair of the Department of Systems Biology and the Norman and Sadie Lee Foundation Endowed Professor in Pediatrics, found a connection between drug-resistance in acute lymphoblastic leukemia (ALL) and increased sugar uptake in the ALL cells, according to the paper titled, “Metabolic gatekeeper function of B-lymphoid transcription factors,” published today in Nature.
City of Hope’s Markus Müschen, M.D., Ph.D., the founding chair of the Department of Systems Biology, has received The Norman and Sadie Lee Foundation Professorship in Pediatrics. Müschen is the first City of Hope physician-scientist to serve as the Lee professor in pediatrics.