Key Publications

Past Five Years

S.P. Wang, Z. Tang, C.W. Chen, M. Shimada, R.P. Koche, L.H. Wang, T. Nakadai, A. Chramiec, A.V. Krivtsov, S.A. Armstrong, R.G. Roeder. A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription. Molecular Cell. 2017; 67(2):308-321.

D.G. Valerio, H. Xu, C.W. Chen, T. Hoshii, M.E. Eisold, C. Delaney, M. Cusan, A.J. Deshpande, C.H. Huang, A. Lujambio, Y.G. Zheng, J. Zuber, T.K. Pandita, S.W. Lowe, S.A. Armstrong. Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis. Cancer Research. 2017; 77(7):1753-1762.

S.C.W. Lee, H. Dvinge, E. Kim, H. Cho, J.B Micol, Y.R. Chung, B.H. Durham, A. Yoshimi, Y.J. Kim, M. Thomas, C. Lobry, C.W. Chen, A. Pastore, J. Taylor, X. Wang, A. Krivtsov, S.A. Armstrong, J. Palacino, S. Buonamici, P.G. Smith, R.K. Bradley, O. Abdel-Wahab. Modulation of Splicing Catalysis for Therapeutic Targeting of Leukemias with Spliceosomal Mutations. Nature Medicine. 2016; 22(6):672-8.

N. Zhu, M. Chen, R. Eng, J. DeJong, A.U. Sinha, N.F. Rahnamay, R. Koche, F. Al-Shahrour, J.C. Minehart, C.W. Chen, A.J. Deshpande, H. Xu, S.H. Chu, B.L. Ebert, R.G. Roeder, S.A. Armstrong. MLL-AF9- and HOXA9-mediated Acute Myeloid Leukemia Stem Cell Self-renewal Requires JMJD1C.  Journal of Clinical Investigation. 2016; 126(3):997-1011.

M.W. Kühn, E. Song, Z. Feng,  A. Sinha,  C.W. Chen,  A.J. Deshpande,  M. Cusan,  N. Farnoud,  A. Mupo,  C. Grove,  R. Koche,  J.E. Bradner,  E. de Stanchina,  G.S. Vassiliou,  T. Hoshii,  S.A. Armstrong.  Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia. Cancer Discovery. 2016; 6(10):1166-1181.

H Xu, D.G. Valerio, M.E. Eisold, A. Sinha, R.P. Koche, W. Hu, C.W. Chen, S.H. Chu, G.L. Brien, J.J. Hsieh, P. Ernst, S.A. Armstrong. NUP98-fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis. Cancer Cell. 2016; 30(6):863-878.

S.F. Cai, C.W. Chen, S.A. Armstrong. Drugging Chromatin in Cancer: Recent Advances and Novel Approaches. Molecular Cell. 2015; 60(4):561-70.

A.J. Deshpande, A.A. Deshpande, A.U. Sinha, L. Chen, J. Chang, A. Cihan, M. Fazio, C.W. Chen, N. Zhu, R. Koche, L. Dzhekieva, G. Ibáñez, S. Dias, D. Banka, A. Krivtsov, M. Luo, R.G. Roeder, J.E. Bradner, K.M. Bernt, S.A. Armstrong. AF10 Regulates Progressive H3K79 Methylation and Hox Gene Expression in Diverse AML Subtypes. Cancer Cell. 2014; 26(6); 896-908.

C.W. Chen, S.A. Armstrong. Targeting DOT1L and HOX Gene Expression in MLL-rearranged Leukemia and Beyond. Experimental Hematology. 2015; 43(8); 673-684.
 
C.W. Chen, R. Koche, A. Sinha, A. Deshpande, N. Zhu, R. Eng, J. Doench, H. Xu, S. Chu, J. Qi, X. Wang, C. Delaney, K.M. Bernt, D.E. Root, W.C. Hahn, J.E. Bradner, S.A. Armstrong. DOT1L Inhibits SIRT1-mediated Epigenetic Silencing to Maintain Leukemic Gene Expression in MLL-rearranged Leukemia. Nature Medicine. 2015; 21; 335-343.